DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde1c and pde6b

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_685002.1	Gene:	pde6b / 559332	ZFINID:	ZDB-GENE-090421-2	Length:	854	Species:	Danio rerio

Alignment Length:	432	Identity:	108/432 - (25%)
Similarity:	175/432 - (40%)	Gaps:	109/432 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   751 FDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVD 815
            |..|..||.   |:| ....:::...|.:.||::...:|..|::.|.:||.|.  .|||..|..:
Zfish   507 FSDFDCTEL---QLV-MCGIQMYYEVGVVKKFQVPQEVLVRFMYSVSKGYRRI--TYHNWRHGFN 565

  Fly   816 VMQTIHYCLCNTG-LMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLEN 879
            |.||: :.|..|| |..:.||||:.|.:.|..|||.:|.||.|.:.|.|.:..|.|:.. ::||.
Zfish   566 VGQTM-FTLLTTGKLKQYYTDLEVMAMITAGFLHDIDHRGTNNLYQVKSQNPLAKLHGS-SILER 628

  Fly   880 HHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEA---- 940
            ||......||.|:..||..:|:|.:...:..|:...::.||:..:|::....::::.|.|.
Zfish   629 HHLEFGKFLLGEESLNIFQNLNRRQTEHVFHLIDIAIIATDLALYFKKRTMFQKIVDLSETYEER 693

  Fly   941 ----------TIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKEL--GLPFS 993
                      |..|:.|:::::..||:|...|.|.|..:..:.:..||:.|||||:.:  ..|.
Zfish   694 KKWIDFMSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALSVAAEFWEQGDLERTVLEQQPI- 757

  Fly   994 PLCDRNNTL-VAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNS 1057
            |:.|||... :.:.|..||||:                           .|.|..|
Zfish   758 PMMDRNKAAELPKLQCGFIDFV---------------------------CTFVYKE--------- 786

  Fly  1058 AIVIPNSGITPSMDKPRDHRTEAKTTAAECLARKSVTGTTASKFNIP--KPWLTCLVENKRIWKE 1120
                                                    .|:|: |  ||....::.|:..|||
Zfish   787 ----------------------------------------FSRFH-PEIKPMFDGILNNRMHWKE 810

  Fly  1121 QAVKDAEARALATAAEEAAAAAAAEAEESKPETETADGEQSE 1162
               :..|..|...|.|||..|....|.::...:.:..|..|:
Zfish   811 ---RQEEYEAKLKAMEEAVKARQEAAAKNAANSNSTGGSGSK 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	71/236 (30%)
pde6b	XP_685002.1	GAF	72..210	CDD:214500
		GAF	253..440	CDD:214500
		PDEase_I	557..801	CDD:278654	79/323 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920