Protein Alignment Pde1c and PDE6B

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_054206142.1
• Gene: PDE6B / 5158
• HGNCID: 8786
• Length: 1022
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 147/690 - (21%)
• Similarity: 233/690 - (33%)
• Gaps: 212/690 - (30%)

  Fly   455 DMQRNLHYAARVLEAVFIDESREGCNGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEASPGGA 519
            |::|..|.|...:.|.               |||.|:|.|..|..::....:
Human   325 DIERQFHKAFYTVRAY---------------LNCERYSVGLLDMTKEKEFFD------------- 361

  Fly   520 GAGVTPGADNQDSIESRTKGVSQAPQTHSGPTGPPSNTSSETIAQPAPKLQPALETVRESVMEES 584
                         :.|...|.|   |.:|||..|...   |.:....  :...|....|..:..:
Human   362 -------------VWSVLMGES---QPYSGPRTPDGR---EIVFYKV--IDYILHGKEEIKVIPT 405

  Fly   585 PSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAES---QAGSAGSSG-----SCSNPAAV 641
            ||.|..       |..|.|.|....|.......:|.|.|.   |.|:...||     ..|.|...
Human   406 PSADHW-------ALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVN 463

  Fly   642 HRQRRLRTPTWARSMSTNKTRLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPK 706
            .::..:...|:   .:....:..||.||:               |..:.|:.:..|...:|...|
Human   464 KKEEIVGVATF---YNRKDGKPFDEQDEV---------------LMESLTQFLGWSVMNTDTYDK 510

  Fly   707 FRSVAHAIRAGIFVDRMYRRV--SSSALTAFPPDVVRLLKNLDD-----------------WTFD 752
            ...:.:  |..|..|.:...|  ....:....|...||.|...|                 .|||
Human   511 MNKLEN--RKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFD 573

  Fly   753 V----FALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHA 813
            :    |:..|.....:|| ...:::...|.:.||:|...:|..||..:.:||.|.  .|||..|.
Human   574 IYEFHFSDLECTELDLVK-CGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRI--TYHNWRHG 635

  Fly   814 VDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLE 878
            .:|.||:...|....|.::.||||.||.:.|.|.||.:|.||.|.:.:.|.:..|.|:.. ::||
Human   636 FNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGS-SILE 699

  Fly   879 NHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDM---------------------- 921
            .||......||.|:..||..:|:|.:...:..|:...::.||:
Human   700 RHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKCAPSGRGRLAGRAGSLG 764

  Fly   922 ----------------------------------------------------------------- 921
                                                                             
Human   765 PPADTGAQRRHSPGDAAPDSVPARRPRAPRMGPRSGSAPPCRRALGAGSPHLLPPAPPLFPGFRK 829

  Fly   922 ----------TNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLE 976
                      :.::|..|:..:.|:|:  |..|:.|:::::..||:|...|.|.|..:..:|:..
Human   830 RAMFQKIVDESKNYQDKKSWVEYLSLE--TTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAA 892

  Fly   977 EFFRQGDLEKE-LGLPFSPLCDRNNTL-VAESQICFIDFI 1014
            ||:.|||||:. |.....|:.|||... :.:.|:.||||:
Human   893 EFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFV 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	11/59 (19%)
		PDEase_I	807..1027	CDD:459723	71/307 (23%)
PDE6B	XP_054206142.1	GAF	144..303	CDD:214500
		GAF	325..512	CDD:214500	50/260 (19%)
		PDEase_I	629..954	CDD:459723	71/307 (23%)