DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde1c and PDE1B

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_011536758.1	Gene:	PDE1B / 5153	HGNCID:	8775	Length:	537	Species:	Homo sapiens

Alignment Length:	509	Identity:	233/509 - (45%)
Similarity:	325/509 - (63%)	Gaps:	47/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   649 TPTWARSMSTNKTR-LADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAH 712
            |.:...::..::|| :.|.:|||.|::.||||.|||:|||||||:|.....|:::|||||||:.|
Human    64 TASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVH 128

  Fly   713 AIRAGIFVDRMYRRVSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYG 777
            |::|||||:||:||..:|....:...|:..|||||.|.||||:|.:||....::.:.:||..|:.
Human   129 AVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHN 193

  Fly   778 SIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASL 842
            .|.:|||....|.:||..:|.||.:|:|||||.:||.||.||:|..|..||:::.|:::|:.|.:
Human   194 LISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAII 258

  Fly   843 LAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRE 907
            .||.:||||||||||:||:.:.||.|::||||:||||||.|:.|||:::||.||..:|:::||.|
Human   259 FAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVE 323

  Fly   908 LRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTM 972
            ||.|||||||.|||:.||||:|.|:..|. |...|||.|.|||:||..|||||.|||.||.|||.
Human   324 LRALVIEMVLATDMSCHFQQVKTMKTALQ-QLERIDKPKALSLLLHAADISHPTKQWLVHSRWTK 387

  Fly   973 LLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIA--- 1034
            .|:||||||||.|.||||||||||||.:||||:|||.||||||||:..|::|:.|..:.|:|
Human   388 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADED 452

  Fly  1035 PMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTEAKTTAAECLARKSVTGTTAS 1099
            ..:|::|:.....                    ||:|      .|......:.::.:|.
Human   453 SKSKNQPSFQWRQ--------------------PSLD------VEVGDPNPDVVSFRST------ 485

  Fly  1100 KFNIPKPWLTCLVENKRIWKEQA---VKDAEARALATAAEEAAAAAAAEAEESK 1150
                   |:..:.|||:.|||:|   :.:..:....:..||.|..:.||.|.::
Human   486 -------WVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQ 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	34/55 (62%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	136/218 (62%)
PDE1B	XP_011536758.1	PDEase_I_N	82..138	CDD:285672	34/55 (62%)
PDE1B	XP_011536758.1	PDEase_I	223..450	CDD:278654	138/227 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	304	1.000	Domainoid score	I1377
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1225
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439875at33208
OrthoFinder	1	1.000	-	-		FOG0001902
OrthoInspector	1	1.000	-	-		otm41086
orthoMCL	1	0.900	-	-		OOG6_100946
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4957
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.000