Protein Alignment Pde1c and PDE7A

DIOPT Version :9

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_001229247.1
• Gene: PDE7A / 5150
• HGNCID: 8791
• Length: 482
• Species: Homo sapiens
• Alignment Length: 487
• Identity: 134/487 - (27%)
• Similarity: 224/487 - (45%)
• Gaps: 60/487 - (12%)

  Fly   618 SAKAAESQAGSAGSSGSCSNPAAVHRQRRL-------RTPTWARSMSTNKTR-LADEDDE----- 669
            |.:.|.|.:.|:...| |.||..:.::|..       :|..:.|.:...:.| .|..:.|
Human    22 SRRGAISFSSSSALFG-CPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSH 85

  Fly   670 ----------LSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMY 724
                      .||::.......:|..|  :|.|.:.:||       .||..|.:....|..|...
Human    86 PYIDFRIFHSQSEIEVSVSARNIRRLL--SFQRYLRSSR-------FFRGTAVSNSLNILDDDYN 141

  Fly   725 RRVSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGIL 789
            .:...            :|:.:.:|.||:|......:|..:..:.:.||:.:|.|..|.:....|
Human   142 GQAKC------------MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKL 194

  Fly   790 EAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTG 854
            ..||..::|.| ..:|||||.:||.||.|.:|..|....|.|.:|..:|..||:||..||.:|.|
Human   195 RRFLVMIQEDY-HSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 258

  Fly   855 TTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGT 919
            ....|.:.:....|.||.:.:||||||..::..||||.  .:.|||..|..:::...:..::|.|
Human   259 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLPLESRQQMETQIGALILAT 321

  Fly   920 DMTNHFQQMKAMRQLL----TLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFR 980
            |::...:.:...|..|    ...|.|..:..||.:.|.|.||.:|.:.|.:..:|:..:.||||.
Human   322 DISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH 386

  Fly   981 QGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEP-----SMGVMSDMLELILAPIAPMNKSK 1040
            |||:||:..|..||||||:...:|..||.|:.::|||     :....:.:.:.:|..:. :||:.
Human   387 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVG-LNKAS 450

  Fly  1041 PATLVEHETTANSTTNSAIVIPNSGITPSMDK 1072
            ...| :.|.:::..|::|..: ||.:.|..::
Human   451 WKGL-QREQSSSEDTDAAFEL-NSQLLPQENR 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	13/70 (19%)
		PDEase_I	807..1026	CDD:278654	79/227 (35%)
PDE7A	NP_001229247.1	PDEase_I	211..444	CDD:395177	80/234 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920