Protein Alignment Pde1c and PDE1C

DIOPT Version :9

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_016867753.1
• Gene: PDE1C / 5137
• HGNCID: 8776
• Length: 804
• Species: Homo sapiens
• Alignment Length: 752
• Identity: 281/752 - (37%)
• Similarity: 388/752 - (51%)
• Gaps: 219/752 - (29%)

  Fly   421 ESLPPVDTPDALNKAAGRIRSLLRRMDHETVAYEDMQRNLHYAARVLEAVFIDESREGCNGNCKN 485
            :.||.:|:|:.|.|.:.|:|||:::::....:..|:::||.|||.|||:|:|||:|
Human   121 DELPQLDSPEVLVKTSFRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETR--------- 176

  Fly   486 LNCSRHSHGRDDQQQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGVSQAPQTHSGP 550
                                                                             
Human   177 ----------------------------------------------------------------- 176

  Fly   551 TGPPSNTSSETIAQPAPKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATA 615
                                                                             
Human   177 ----------------------------------------------------------------- 176

  Fly   616 EPSAKAAESQAGSAGSSGSCSNPAAVHRQRRLRTPTWARSMSTNKTRLADEDDELSEVQPDAVPP 680
                                                          ||.|.:||||::|.||||.
Human   177 ----------------------------------------------RLLDTEDELSDIQSDAVPS 195

  Fly   681 EVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLLKN 745
            |||:||||||||||....|:|||||:|:|:.||::|||||:|||||.|:....::||.|:..||:
Human   196 EVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKD 260

  Fly   746 LDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNN 810
            :|.|:||||:|.||:....:|::.|||..||..|.:|||....|.:|:..:|.||.:::|||||.
Human   261 VDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNL 325

  Fly   811 LHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRA 875
            :||.||.||:||.|..||:.||||:|||||.:.:|.:|||||||||||||:.:.|:.|:|||||:
Human   326 MHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRS 390

  Fly   876 VLENHHASASFRLLRED-EYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQE 939
            ||||||.||::|||::| |.|||.:||::::||.|.||||||:.|||:.||||:|||:..|...|
Human   391 VLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE 455

  Fly   940 ATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVA 1004
            | |:|.|.|||:||..|||||||.|.:||||||.||||||||||.|.||||||||||||.:|:||
Human   456 A-IEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVA 519

  Fly  1005 ESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPS 1069
            :||:.||||||||:..|::||.|.|::|:.. ..|:.....:..::.||.::|..
Human   520 QSQVGFIDFIVEPTFTVLTDMTEKIVSPLID-ETSQTGGTGQRRSSLNSISSSDA---------- 573

  Fly  1070 MDKPRDHRTEAKTTAAECLA--RKSVTGTTASKFNIPKPWLTCLVENKRIWK------EQAVKDA 1126
                  .|:..||:.:|..|  ..||.......|.  ..|...:..|:..|:      |:|.|:|
Human   574 ------KRSGVKTSGSEGSAPINNSVISVDYKSFK--ATWTEVVHINRERWRAKVPKEEKAKKEA 630

  Fly  1127 EARA-LATAAEEAAAAAAAEAEE---SKPETETADGE 1159
            |.:| ||...::....|.::|||   .|.|.:|: ||
Human   631 EEKARLAAEEQQKEMEAKSQAEEGASGKAEKKTS-GE 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	37/55 (67%)
		PDEase_I	807..1026	CDD:278654	144/219 (66%)
PDE1C	XP_016867753.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	304	1.000	Domainoid score	I1377
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1225
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439875at33208
OrthoFinder	1	1.000	-	-		FOG0001902
OrthoInspector	1	1.000	-	-		otm41086
orthoMCL	1	0.900	-	-		OOG6_100946
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4957
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.000