DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde1c and PDE1A

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_016859783.1	Gene:	PDE1A / 5136	HGNCID:	8774	Length:	586	Species:	Homo sapiens

Alignment Length:	508	Identity:	243/508 - (47%)
Similarity:	333/508 - (65%)	Gaps:	46/508 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   662 RLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRR 726
            ||.|.:||||::|.|:||.|||:||||||||:|..:::|.:|||||||:.||::|||||:||||:
Human    73 RLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRK 137

  Fly   727 VSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEA 791
            .......|:|..|:..||::|.|:||||||.||:....:|::.||||.||..|::|||....|..
Human   138 TYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIT 202

  Fly   792 FLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTT 856
            |...:|.||.:|:|||||.:||.||.||:||.:.:||:|:|||:|||.|.:.||.:|||||||||
Human   203 FAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTT 267

  Fly   857 NNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDM 921
            ||||:.:.|:.|:|||||:||||||.||::||::|:|.|||.:||::::|:||.|||||||.|||
Human   268 NNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDM 332

  Fly   922 TNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEK 986
            :.||||:|.:|..|...|. ||:.|.:||:||..|||||||.|.:|:||||.|:||||.|||.|.
Human   333 SGHFQQIKNIRNSLQQPEG-IDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEA 396

  Fly   987 ELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAP-IAPMNKSKPATLVEHETT 1050
            ||||||||||||.:|:||:|||.||||||||:..:::|..|.|:.| |...:|::.::.|    .
Human   397 ELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYV----A 457

  Fly  1051 ANSTTNSAIVIPNSGITPSMDKPRDHRTEAKTTAAECLARKSVTGTTASKFNIP---------KP 1106
            ::|||...:.|                       |:.|.|.:..|:.:.....|         |.
Human   458 SSSTTIVGLHI-----------------------ADALRRSNTKGSMSDGSYSPDYSLAAVDLKS 499

  Fly  1107 WLTCLV----ENKRIWKEQAVK----DAEARALATAAEEAAAAAAAEAEESKP 1151
            :...||    :||..|||.|.:    |.....:::..|:..|....|..|..|
Human   500 FKNNLVDIIQQNKERWKELAAQALSSDHVLYHVSSTIEQEYAFDRVELSEETP 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	35/55 (64%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	137/218 (63%)
PDE1A	XP_016859783.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	304	1.000	Domainoid score	I1377
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21043
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1225
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439875at33208
OrthoFinder	1	1.000	-	-		FOG0001902
OrthoInspector	1	1.000	-	-		otm41086
orthoMCL	1	0.900	-	-		OOG6_100946
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4957
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	12.000