Protein Alignment Pde1c and Pde6

DIOPT Version :9

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Alignment Length: 1199
• Identity: 252/1199 - (21%)
• Similarity: 415/1199 - (34%)
• Gaps: 409/1199 - (34%)

  Fly   174 SSGGTSGAATSSSSSGGGAASGA-------ASGSVGPASGTATGTGS--ASGGAGG--------- 220
            |:..:|.|||:|:||.....:||       |:|.|.|.:....|:|:  ||..:|.
  Fly    18 STTSSSSAATTSASSSKPLTNGANKTAISTAAGGVTPGAVPGPGSGAIPASSSSGNQVKLEHHHR 82

  Fly   221 -----------------VSTPAQEAASPTVSELSGSGSNATINGQVARHGSLTIIRRTNSRNFTQ 268
                             :.||...::||:.|.   |.:.|:|..|                  |.
  Fly    83 QSNNNRPAVTNRSSETKLMTPTGSSSSPSQSP---SQTQASIQTQ------------------TS 126

  Fly   269 FDGQLASPSSTACSSTAPGIG--FAQTPLSEPLAERLSFRASGGSNGSASAG-DSRSSNQGPSNS 330
            ...:||..|:||.......:.  |.:.|  |...:.|:.||...:....... ::|..::.||.:
  Fly   127 QQDRLAKASTTASQQDVDEVARLFEEKP--EAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVT 189

  Fly   331 GP------AASAAVKMQPSSPNATNYLADNIQISSANLSQTE-----MVVGRDSADY----TAMH 380
            ..      |||..|: |.|..:.:|..|.::.....:|...:     |.:.||.|:.    ...|
  Fly   190 SDLFQQWMAASPTVQ-QKSPRSLSNSSASSLPECRRHLMDLDEGELFMELIRDVANELDIDVLCH 253

  Fly   381 SI--NVGV------GNSFL-RGDTDIPQESGHSFETPSNMSFTAGQWDTESLPPVDTPDALNKA- 435
            .|  |||:      |:.|| :|             ||:|....|..:|......:  .||:.:|
  Fly   254 KILVNVGLLTHADRGSLFLAKG-------------TPTNKYLVAKLFDVTQKTAL--KDAVTRAS 303

  Fly   436 ------------AGRIRSLLRRMDHETVAYEDMQRN-------------------LHYAARVLEA 469
                        ||.: :..::|.:...||:|.:.|                   .:|...::..
  Fly   304 AEEIIIPFGIGIAGMV-AQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGV 367

  Fly   470 VFIDESREGCN---------------------GNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQE 513
            ..|.....||.                     .|.:....|...:.|:   |...|..||.
  Fly   368 AQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRN---QILLNLARSI---- 425

  Fly   514 ASPGGAGAGVTPGADNQDSIESR-TKGVSQAPQ-------------------THSGPTGPPSNTS 558
                         .:.|:::|.. ||.:::|.:                   :|          .
  Fly   426 -------------FEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASH----------L 467

  Fly   559 SETIAQPAPKLQPALETVRES-VMEESPSKDP----GDKGPPPPASTSTLTSQTTTSSSATAEPS 618
            .:.|.:|.   |||...::.: ..||...::.    .:.|....|:..:..|.:..|||..|:.:
  Fly   468 EKIIEKPN---QPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQIA 529

  Fly   619 AKAAESQAGSAGSSGSCSNPAAVHRQRRLRTPTWARSMSTNKTRLADEDDELSEV---------- 673
            ...|        ::|...|...|..        |.|  ..|:.|..||.|....:
  Fly   530 QFVA--------TTGQTVNICDVIE--------WVR--DHNQIRAEDEIDSTQAILCMPIMNAQK 576

  Fly   674 ----------QPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMY---- 724
                      :.:.||          ||...|:.         |.:.|.....||...:||
  Fly   577 KVIGVAQLINKANGVP----------FTDSDASI---------FEAFAIFCGLGIHNTQMYENAC 622

  Fly   725 -----RRVSSSAL----TAFPPDVVRLLK---------NLDDWTFDVFALTEAASGQVVKYVAYE 771
                 ::|:...|    ||......:|.:         ||..:||..|.|.:..:.:.|    ..
  Fly   623 KLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAV----LR 683

  Fly   772 LFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLM-NWLTD 835
            :|.:...:.:|:|...:|..::..|.:.|...:  |||..||::|.||: :.:..||.| .::||
  Fly   684 MFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKMERFMTD 745

  Fly   836 LEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHL 900
            |||...|:|.|.||.:|.||.|.|...:.|..|:||. .:.:|:||......:|..:..||...|
  Fly   746 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQAL 809

  Fly   901 SREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATID------KQKVLSLVLHCCDISH 959
            |.|::|.:...|...:|.||:..:|::..|..:|  ::....|      |..:..:::..||:|.
  Fly   810 SPEDYRSVMKTVESAILSTDLAMYFKKRNAFLEL--VENGEFDWQGEEKKDLLCGMMMTACDVSA 872

  Fly   960 PAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLC----DRNNTLVAESQICFIDFIVEPSMG 1020
            .||.|.|.|:...|:.:|||.|||||| |.|...|:.    :|.:.| .:.|:.|||.|..|...
  Fly   873 IAKPWEVQHKVAKLVADEFFDQGDLEK-LQLNTQPVAMMDRERKDEL-PKMQVGFIDVICLPLYR 935

  Fly  1021 VMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTEAKTTAA 1085
            |:.|..
  Fly   936 VLCDTF----------------------------------------------------------- 941

  Fly  1086 ECLARKSVTGTTASKFNIPKPWLTCL----VENKRIWKEQAVK--------DAEARALATAAEEA 1138
                                ||:|.|    :||:|.|::.|.|        |.:  .:....||.
  Fly   942 --------------------PWITPLYEGTLENRRNWQDLAEKVEMGLTWIDHD--TIDKPVEEF 984

  Fly  1139 AAAAAAEAEESKPETETAD-GEQSEPAAE 1166
            ||.|..|.::.:....|.: .:||:..:|
  Fly   985 AACADEEIKDIEFTVTTLNCNQQSQHGSE 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	11/75 (15%)
		PDEase_I	807..1026	CDD:278654	80/229 (35%)
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	29/174 (17%)
		GAF	431..619	CDD:214500	40/237 (17%)
		PDEase_I	717..950	CDD:278654	84/317 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020