Protein Alignment Pde1c and Pde8

DIOPT Version :9

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_001163275.2
• Gene: Pde8 / 37741
• FlyBaseID: FBgn0266377
• Length: 1050
• Species: Drosophila melanogaster
• Alignment Length: 1061
• Identity: 221/1061 - (20%)
• Similarity: 349/1061 - (32%)
• Gaps: 383/1061 - (36%)

  Fly   298 PLAERLSFRASGGSNGSASAGDSRSSNQGPSNSGPAASAAVKMQPSSPNATNY----LADNIQIS 358
            |...::..|.|...:.|:|||....|::..|::.|.|.|...:...|.:..|.    |.|:..|.
  Fly     6 PKFSKVFRRKSSAKSSSSSAGRENPSSEPDSDTEPYAIAIAAISDRSGDNRNERPRPLPDDDSIR 70

  Fly   359 SANLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGDTDIPQESG-----------HSFETPSNMS 412
            |..:|              |.| :::.||.......|.:|...|           ...||.|..:
  Fly    71 SRLIS--------------AAH-LDLDVGLELASDSTAVPANGGIRPKSEGACPEMKVETISAAT 120

  Fly   413 FTAGQWDTESLPPVDTPDALNKAAGRI--------RSLLRRMDHETVAYE--------DMQRNLH 461
                     |.||   |..|:..:|.:        |:..:..:...:.||        |:...|.
  Fly   121 ---------SPPP---PRPLHGTSGPVAISLPFVGRNSSKTPEEMELEYEANVEAESRDIMTPLR 173

  Fly   462 YAARVLEAVF------------IDESREGCNGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEA 514
            ...|.|...|            |.|:....:.....|| :....|..|.:.:.|::       |.
  Fly   174 RNTRPLSVSFGGGGGRSALQPEIVEAIRSLDVPALRLN-NLSFDGSTDPKGERNHA-------EE 230

  Fly   515 SPGGAGAGVTPGADNQDSIESRTK--------------GVSQAPQTH---SGPTGPPSNTSS--- 559
            .|      :|||.|::||:..|.|              .:.:.|:.|   :|...||:....
  Fly   231 EP------LTPGHDHEDSVVLRRKVNCLERKAHSLYERRLPRVPKLHLLVAGKKNPPTEEEEFRT 289

  Fly   560 ----------ETIAQPAPKLQPAL-----ETVRES--------------VMEESPSKDPGDKGPP 595
                      .|:..|.|.|:..|     :::.|:              |..:..:.|...|...
  Fly   290 FQRNLMDLKYPTVLPPNPPLKALLVFHKSDSICEAITAACQRHQLDVTLVKSKEEALDTLQKSYA 354

  Fly   596 PPASTSTLTSQTTTSSSATAEPSAKAAESQAG-------------------------SAG----- 630
            .......:.....:|.:..||..|:......|                         .||
  Fly   355 TAQCYHLIIIDARSSKNLDAEHIARTIRHTHGHHLTTIIAVCKKSFFEKDDVLIALLDAGVNRCV 419

  Fly   631 ----SSGSCS-----------NP-----------AAVHRQRR--LRTPTWARSMSTNKT--RLAD 665
                :...||           .|           .|:||.:.  |.|....|....|:.  ||.:
  Fly   420 AETTNLAMCSVELKQILHSIIRPHNVMSTQQALYTALHRLKEVVLITDDLLRIQYANRATERLLN 484

  Fly   666 E--DDELSEVQPDAVPPEVREWLASTFTRQ---------MATSRRKSDE---------------- 703
            .  |:.:|:...|....::     ||.:.|         :.|.||||.|
  Fly   485 MRLDEIISKQLEDIFVSDL-----STISEQCKNIKEFDGILTVRRKSQEGIPMHVRVVPVACIGS 544

  Fly   704 -----------------------KPKF--RSVAHAIRAGIFVDRM-----YRRVSSSALTAFP-- 736
                                   :||.  |...|::|...|..|.     .||.|.:.||:.|
  Fly   545 APTHLIFNFDVPGGQMDFIATLPQPKEAPRGSLHSVRRCSFDVRSIASDGLRRTSLAKLTSLPLE 609

  Fly   737 ----------------------------------------------------------------- 736
                                                                             
  Fly   610 APITKIINLLSQVQENCSADEARLIDKVLEFLKREGLYSPQMKEIRTDDPIATDLIGALLTGPSV 674

  Fly   737 -------------------------------PDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAY 770
                                           |.::.||.....|.||:|.|.|......:.|:..
  Fly   675 YSSRRSSNDSIIRTGSSTRTAAIVPAKMKSNPIIMELLDESLSWDFDIFKLEEITDYHPLLYLGM 739

  Fly   771 ELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTG-LMNWLT 834
            |:|.|:.......|...:.:|:|..:|..| |..|.|||:.||.||||.       || .:..||
  Fly   740 EMFRRFDVFATLNIDENVCKAWLAVIEAHY-RKSNTYHNSTHAADVMQA-------TGAFITQLT 796

  Fly   835 D--------LEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRL-LR 890
            :        :|...:|:||..||.:|.|.::.|...|....|:||||..|||||||:.:|:| |.
  Fly   797 NKDMLVMDRMEEATALIAAAAHDVDHPGRSSAFLCNSNDALAVLYNDLTVLENHHAAITFKLTLG 861

  Fly   891 EDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQE------ATIDKQKVL- 948
            :|:.||..:|.:|.::..|..:|:|:|.|:||.||:.:.....:...:|      .|.::..:|
  Fly   862 DDKINIFKNLDKETYKSARSTIIDMILATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILM 926

  Fly   949 -SLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPF-SPLCDRNNTLVAESQICFI 1011
             .:::...|:|:||:.......|...:.||:|.|.|.||:..||. .|:.||....:.:|||.||
  Fly   927 RRMLIKVADVSNPARPMQFCIEWARRIAEEYFMQTDEEKQRHLPIVMPMFDRATCSIPKSQIGFI 991

  Fly  1012 DFIVEPSMGVMS---DMLELI 1029
            ::|::..|....   ||.:||
  Fly   992 EYIIQDMMHAWESFIDMPQLI 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	18/107 (17%)
		PDEase_I	807..1026	CDD:278654	80/240 (33%)
Pde8	NP_001163275.2	PAS	459..539	CDD:238075	18/84 (21%)
		PAS_9	463..539	CDD:290162	18/80 (23%)
		PDEase_I	775..1016	CDD:278654	83/245 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020