DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde1c and Pde11

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster

Alignment Length:	1357	Identity:	255/1357 - (18%)
Similarity:	441/1357 - (32%)	Gaps:	411/1357 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 PRRESLNSCEVGSPGTMSSSLGKAGRLNSSRYPSGGA--GAIGLSVMGNLVGTTTRKCVLTLDGY 149
            |....|:...:..|.|........||:|:.:   ||.  |..|.|....|:.|......|.|
  Fly    61 PATTGLHLRSIEEPATTPLQFQPTGRMNTEQ---GGTGYGGYGSSEHSLLIATRHAGVPLPL--- 119

  Fly   150 SYVIVASTPESLPSK----RDEASGGPGSSGGTSGAATSSSSSGGGA------------------ 192
                  :..:.||:.    ....:..|.||.|       |||||||.
  Fly   120 ------AQHQPLPAHYQPLNHSGAAPPSSSNG-------SSSSGGGVQTSATPQQQQQYQVQQPY 171

  Fly   193 -----------------------------------------------------------ASGAAS 198
                                                                       |:.|.:
  Fly   172 QYQYQHHYHHQANSPQHHRPYDPEHARMEAWLDENQEFVQDYFIRKATRQTVDAWLVSHATSAGN 236

  Fly   199 GSVGPASGT-ATGTGSASGGAGGVSTPAQEAAS----------PTVSELSGSGSNATI-----NG 247
            ..|...|.| |.|..|:|.|..|.:||.::.::          |.|:.:.|:.:..:|     ||
  Fly   237 DVVSSTSPTHANGQTSSSRGGSGATTPVRKISAHEFERGGLLKPIVNTIDGTPTFLSIGPPMDNG 301

  Fly   248 QVARHGSLTIIRRTNS--RNFTQFDGQLASPSSTACSSTAPGIGFAQTPLSEPLAERLSFRASGG 310
            .|.  ||.:.::....  ....|::.|....:......:                 :.|...:||
  Fly   302 SVG--GSCSNLQNVGGVVAGQYQYNHQQHHHNHAHLHHS-----------------QHSHYQAGG 347

  Fly   311 SNGSASAGDSRSSNQGPSNSGPAASAAVKMQPSSPNATN-------YLADNIQISSAN----LSQ 364
            :.||:|.|    |..|.|.:|.|.|..     .|..|.|       :.....|..|.|    |.:
  Fly   348 AVGSSSLG----STGGASGAGGAPSLG-----GSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDE 403

  Fly   365 TEMV------VGRDSADYTAMHSI--NVGV------GNSFL-----RGDTDI------------P 398
            .|::      :..:....|..|.|  ||.:      |:.||     .|...:            |
  Fly   404 KELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCP 468

  Fly   399 QESGHSFETPSNMSFTAGQWDT-------ESLPPVDTPDA---------LNKAAG-RIRSLLRRM 446
            :.:....|....:...   |.|       ||..||:.|||         ::...| |.::||
  Fly   469 RSTVEEMEQQDEVRVA---WGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALL--- 527

  Fly   447 DHETVAYEDMQRNLHYAARVLEAVFIDESREGCNGNCKNLNCSRHSHGRDDQQ------QDNNNS 505
               .:..:|...::...|:|:..:         ||.|         ....|::      |.....
  Fly   528 ---CMPIKDSSGDVIGVAQVINKM---------NGEC---------FSEIDEKVFSSYLQFCGIG 571

  Fly   506 NRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGVSQAPQTHSGPTGPPSNTSSETIAQPAPKLQ 570
            .|:..|.|.|              |..|:.....:..|.....     ..:|....:.:....:|
  Fly   572 LRNAQLYEKS--------------QLEIKRNQVLLDLARMIFE-----EQSTIEHMVFRILTHMQ 617

  Fly   571 PALETVRESVM--EESPSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQAGSAGSSG 633
            ..::..|..::  .|:   |.|..........:.|:.:..||.::..|..........|...::|
  Fly   618 SLIQCQRVQILLVHEA---DKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTG 679

  Fly   634 SCSNPAAVHRQRRLRTPTWARSMSTNKTRLADE-DDELSEVQPDAVPPEVREWLASTFTRQMATS 697
            ...|....:...|........|...:::.|... .:.|.::  ..|...:.::....||
  Fly   680 ETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQI--IGVIQLINKFNELDFT------ 736

  Fly   698 RRKSDEKPKFRSVAHAIRAGIFVDRMYRR-------------VSSSALTAFPPDVVRLLK----- 744
              |:||. ...:.|.....||....||.:             |.|...:|...:..||.:
  Fly   737 --KNDEN-FVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPS 798

  Fly   745 ----NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRN 805
                .|.|:.||.....:   ...:| ....:|.....:.:|.|...:|..:|..|::   .|||
  Fly   799 AVHFRLHDFKFDDIHFED---DDTLK-ACLRMFLDLDFVERFHIDYEVLCRWLLSVKK---NYRN 856

  Fly   806 -PYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETAL 869
             .|||..||.:|.|.:...|..|.......::|..|.::..|.||.:|.||.|:|.:.:.|..|.
  Fly   857 VTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQ 921

  Fly   870 LYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQ----MKA 930
            ||: .:.:|:||......:|......||::||.:::..:..::.:.:|.||:..:|::    :::
  Fly   922 LYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLES 985

  Fly   931 MRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPL 995
            :.|..:...|...:..:.::.:..||:|...|.|.:..|...|:..|||.|||:||: .|..:|:
  Fly   986 VSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQ-ELNITPI 1049

  Fly   996 CDRNNTLVAE---SQICFIDFIVEP---SMGVMSDMLELIL------------------------ 1030
            ...|.....|   .|:.|||.|..|   :...:||.||.::
  Fly  1050 DIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQD 1114

  Fly  1031 ------------------------------APIAPMNKSKPATLVEHETTAN--STTNSAIVIPN 1063
                                          |.:|..:.|:.|: |.....||  |.||..|.:.:
  Fly  1115 QEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKAS-VNGSNVANNSSNTNKKIAVAS 1178

  Fly  1064 SGITPSMDKPRD-------------------HRTEAKTTAAECLARKSVTGTTASKFNIPKPWLT 1109
            .   |:..:|.|                   :..:|:...|.|.:..:.:.:|||         :
  Fly  1179 H---PTSTQPSDDDNDVDADADDVDEQAAEENGHDAEVDEASCRSNSTCSSSTAS---------S 1231

  Fly  1110 CLVENKRIWKEQA-----VKDAEARALATAAEEAAAAAAAEAEESKPETETADGEQS 1161
            ||.......::.:     :|..:|:.:|..........:.:|:..|...::.|..:|
  Fly  1232 CLSTPPPTGEDDSTPVSPLKTLQAKLVAANLNALQRQTSNQAQTQKQRCKSCDHSRS 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	10/56 (18%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	64/228 (28%)
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	36/202 (18%)
		GAF	611..762	CDD:214500	27/164 (16%)
		PDEase_I	859..1094	CDD:278654	66/236 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I1950
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020