Protein Alignment Pde1c and dnc

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: NP_726846.1
• Gene: dnc / 31309
• FlyBaseID: FBgn0000479
• Length: 1209
• Species: Drosophila melanogaster
• Alignment Length: 1241
• Identity: 286/1241 - (23%)
• Similarity: 428/1241 - (34%)
• Gaps: 424/1241 - (34%)

  Fly   168 ASGGPGSSGGTSGAATSSSSSGGGAASGAASGSVGPASGTAT---------------GTGSASGG 217
            |:||.|..||       |.|.|||..||:.|||....|...|               |.|||:..
  Fly    52 ATGGVGGGGG-------SGSGGGGCGSGSGSGSGKRKSKARTKCFGGTVFRCCLPCRGGGSAAPA 109

  Fly   218 AGGVSTPAQ--------------------------------EAASPTV--SEL-----SGSGSNA 243
            .....||||                                :..:.||  |||     :|.|:..
  Fly   110 TSPPQTPAQTPDELKVIPEDCNLEKSAEQKRDLLERNNKEDDLLNRTVSGSELDLYGGAGGGTKK 174

  Fly   244 -----TINGQVARHGSL-TIIRRTNSRNFTQFDGQLASPSSTACSSTAPGIGFAQTPLSEPLAER 302
                 ||:..|....|| |:|...:.    :.|.|| |.:..|.:|.|.|:          :|.|
  Fly   175 HSLADTIDTSVTTPISLKTLINDVDE----ELDQQL-SAADIAAASLASGL----------VARR 224

  Fly   303 LSFRASGGSNGSASAGDSRSSNQGPSNSGPAASAAVKMQPSSPNATNYLADNIQISSANLSQTEM 367
            ........::.|.:|...:...|......|...:.....|||.|.              |||..:
  Fly   225 AEPETLSDASVSPTAVVQQQQQQQQQLQQPLLQSQPHFVPSSGNI--------------LSQVTL 275

  Fly   368 VVGRDSADYTAMHSINVGVGNSFLRGDTDIPQESGHSFETPS-NMSFTAGQWDTESLPPVDTPDA 431
            ..|.:.:......::.       .:|....|..:.:....|: |....:.|..|..||.:...:.
  Fly   276 YSGSNPSTNPCQSAVQ-------NQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEE 333

  Fly   432 LNKAAGRIRSLLRRMDHE------TVAYEDMQRNLHYAARVLEAVFIDESREGCNGNCKNLNCSR 490
            .::|..:.::.|:  :|:      |:|                        .|..|:|::::
  Fly   334 SDQANFKHQTSLK--EHQPLPPPITIA------------------------TGYCGSCESVH--- 369

  Fly   491 HSHGRDDQQQDNNNSNRSCSLQEASPGG-------AGAGVTP----------------------- 525
            ||            |..|.|.....|||       ||...||
  Fly   370 HS------------SATSSSAGTVPPGGQQTQEYIAGTSSTPSPRIKLKFRKPHKSCWSRIVLAP 422

  Fly   526 --------------GADNQDSI--ESRTKGVSQAPQTHSG-----------------PTGPPSNT 557
                          |:::.:::  .|.|.|.:...|..|.                 .|..|||:
  Fly   423 IGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNS 487

  Fly   558 SSETIAQPAPKLQP---------------------ALETVRESVMEESPSKDPGDKGPP------ 595
            .    ..|..|:|.                     .|..||..|.....::.|.:.|.|
  Fly   488 Q----LLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGARSPLEGGSPSAGLVL 548

  Fly   596 --------------------PPASTS-------------------------------------TL 603
                                .|.|.|                                     :|
  Fly   549 QNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASL 613

  Fly   604 TSQTTTSSSATAEPSAKAAE--SQAGSAGSSGSCSNPAAV------HRQRRLRTPT-----WA-- 653
            .|......|.|..|::..:.  :|:.||..||   ||...      ....||.|.|     |.
  Fly   614 RSVRNNLLSLTNVPASNKSRRPNQSSSASRSG---NPPGAPLSQGEEAYTRLATDTIEELDWCLD 675

  Fly   654 --------RSMSTN-----KTRLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKP 705
                    ||:|..     |..|..|....||.....  .::.|::.|||     ..:::..:.|
  Fly   676 QLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSG--NQISEYICSTF-----LDKQQEFDLP 733

  Fly   706 KFR------SVAHAIRAGIFVDRMYRRVSS------------------------SALTAFPPDVV 740
            ..|      .||....||......|.|..|                        ..|..|..:..
  Fly   734 SLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETP 798

  Fly   741 R------LLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEG 799
            |      ||..||.|...:|::.|.:..:.:..|||.:|.....:....|.|.....|:..:|:.
  Fly   799 RENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDH 863

  Fly   800 YCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSG 864
            |.: .||:||:|||.||.|:.:..|....|....|.||:..:|.||.:||.:|.|.||.|.|.|.
  Fly   864 YVK-DNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSS 927

  Fly   865 SETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMK 929
            ||.||:|||.:||||||.:.:|:||:....:|..::.:::.:.||.:||::||.|||:.|   |.
  Fly   928 SELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKH---MS 989

  Fly   930 AMRQLLTLQEAT-------------IDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQ 981
            .:..|.|:.|..             .|:.:||..::||.|:|:|.|...::.||..||:||||.|
  Fly   990 LLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQ 1054

  Fly   982 GDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVE 1046
            ||.|:|.|:..||:|||:|..:.:||:.|||:||.|.....:|:       :.|..:....||.|
  Fly  1055 GDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADL-------VHPDAQDILDTLEE 1112

  Fly  1047 HETTANSTTNSAIVIPNSGITPSMDK-PRDHRTEAKTTAAEC----LAR-------------KSV 1093
            :.....|      :||.|.....:|: |::.|...:.|..|.    ||.             ...
  Fly  1113 NRDYYQS------MIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGT 1171

  Fly  1094 TGTTAS 1099
            |||||:
  Fly  1172 TGTTAA 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	14/65 (22%)
		PDEase_I	807..1027	CDD:459723	94/232 (41%)
dnc	NP_726846.1	PDE4_UCR	603..725	CDD:465648	29/131 (22%)
		PDEase_I	870..1110	CDD:459723	95/249 (38%)