DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde1c and Pde1b

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_073201.1	Gene:	Pde1b / 29691	RGDID:	3278	Length:	535	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	232/513 - (45%)
Similarity:	320/513 - (62%)	Gaps:	55/513 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   649 TPTWARSMSTNKTR-LADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAH 712
            |.:...::..::|| :.|.:|||.|::.||||.|||:|||||||:|.....|:::|||||||:.|
  Rat    62 TASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVH 126

  Fly   713 AIRAGIFVDRMYRRVSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYG 777
            |::|||||:||:||..::....:...|...|||||.|.||||:|..||....::.:.:||..|:.
  Rat   127 AVQAGIFVERMFRRTYTAVGPTYSTAVHNCLKNLDVWCFDVFSLNRAADDHALRTIVFELLTRHS 191

  Fly   778 SIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASL 842
            .|.:|||....|.:||..:|.||.:|:|||||.:||.||.||:|..|..||:::.|:::|:.|.:
  Rat   192 LISRFKIPTVFLMSFLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAII 256

  Fly   843 LAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRE 907
            .||.:||||||||||:||:.:.||.|:|||||:||||||.|:.||::::||.||..:|:::||.|
  Rat   257 FAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMMQDDEMNIFINLTKDEFVE 321

  Fly   908 LRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTM 972
            ||.|||||||.|||:.||||:|.|:..|. |...|||.|.|||:||..|||||.|||.||.|||.
  Rat   322 LRALVIEMVLATDMSCHFQQVKTMKTALQ-QLERIDKSKALSLLLHAADISHPTKQWSVHSRWTK 385

  Fly   973 LLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIA--- 1034
            .|:||||||||.|.||||||||||||.:||||:|||.||||||||:..|::|:.|..:.|:.
  Rat   386 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLTDDD 450

  Fly  1035 PMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMD----KPRDHRTEAKTTAAECLARKSVTG 1095
            ..:||:|:.....                    ||:|    .|.......::|
  Rat   451 SKSKSQPSFQWRQ--------------------PSLDVDVGDPNPDVVSFRST------------ 483

  Fly  1096 TTASKFNIPKPWLTCLVENKRIWKEQA---VKDAEARALATAAEEAAAAAAAEAEESK 1150
                       |...:.|||:.|||:|   :.:..:....:..||.|.::.||.|.::
  Rat   484 -----------WTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPSSPAEDEHNQ 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	34/55 (62%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	136/218 (62%)
Pde1b	NP_073201.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Calmodulin-binding. /evidence=ECO:0000255	27..47
		PDEase_I_N	80..136	CDD:400687	34/55 (62%)
		PDEase_I	221..448	CDD:395177	138/227 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..474		7/48 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..535		10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I1318
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1143
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439875at33208
OrthoFinder	1	1.000	-	-		FOG0001902
OrthoInspector	1	1.000	-	-		otm45227
orthoMCL	1	0.900	-	-		OOG6_100946
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970