DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde1c and Pde3b

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_058925.2	Gene:	Pde3b / 29516	RGDID:	61943	Length:	1111	Species:	Rattus norvegicus

Alignment Length:	1078	Identity:	253/1078 - (23%)
Similarity:	394/1078 - (36%)	Gaps:	282/1078 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 PAQEAASPTVSELSGSGSNATINGQV-ARHGSLTIIRRTNSRNFTQFDGQLASPSSTACSSTAPG 287
            ||..||......||..|. .|:..:| .|||.|.::          |.|.:...|.:...:..|.
  Rat   174 PAAAAAGRLCLVLSCVGL-LTLAPRVRLRHGVLVLL----------FAGLVWWVSFSGLGALPPA 227

  Fly   288 --------IGFAQTPLSEPLAERLSFRASGGSNGSASAGDS---------RSS--NQGPSNSGPA 333
                    :|.|...|:..|......|.:.....|||..|.         |||  :.|.|.:|..
  Rat   228 LRPLLSCLVGGAGCLLALGLDHFFHVRGASPPPRSASTADEKVPVIRPRRRSSCVSLGESAAGYY 292

  Fly   334 ASAAVKMQPSSPNATNYLADNIQISSANLSQTEMVV-GRDSADYTAMHSINVGVGN--------- 388
            .|..:..:||.|               .:|:.:|:: ..|...:...|..|.|.||
  Rat   293 GSGKMFRRPSLP---------------CISREQMILWDWDLKQWCKPHYQNSGGGNGVDLSVLNE 342

  Fly   389 -----SFLRGDTDIPQESGHSFETPSNMSFTAGQWDTESLPPVD--TPDALNKAAGRIRSLLRRM 446
                 |.|..|..:|.:...|..:.|::   .|.:.....|.::  ||.........:...:.:.
  Rat   343 ARNMVSDLLIDPSLPPQVISSLRSISSL---MGAFSGSCRPKINSFTPFPGFYPCSEVEDPVEKG 404

  Fly   447 DHETVAYEDMQRNLHYAARVLEAVFIDESR--EGCNGNCKNLNCSRHSHGRDDQQ------QDNN 503
            |          |.||.......:....:.|  .|.:|    |..|.| |.|.|:.      |:.:
  Rat   405 D----------RKLHKGLSSKPSFPTAQLRRSSGASG----LLTSEH-HSRWDRSGGKRPYQELS 454

  Fly   504 NSNRSCSLQEASPGGAGAGVTPGADNQDSI-ESRTKGVSQAPQTHSGPTGPPSNTSSETIAQPAP 567
            .|:..|.|.           .|.:.|..:| :.|:..||..  .|:|        .....|.|:|
  Rat   455 VSSHGCHLN-----------GPFSSNLMTIPKQRSSSVSLT--HHAG--------LRRAGALPSP 498

  Fly   568 KLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTT----SSSATAEPSAKAAESQAGS 628
            .|..:...|                    |.|...||:::..    :|....:||.....
  Rat   499 SLLNSSSHV--------------------PVSAGCLTNRSPVGFLDTSDFLTKPSVTLHR----- 538

  Fly   629 AGSSGSCSNPAAVHRQRRLRTPTWARS--------MSTNKTRLADEDDELSEVQPDAVPPEVREW 685
              |.||.|:.|..|:..|....:...|        :||.:....|..:|.|..:...|  ..:|.
  Rat   539 --SLGSVSSAADFHQYLRNSDSSLCSSCGHQILKYVSTCEPDGTDHHNEKSGEEDSTV--FSKER 599

  Fly   686 LASTFTRQMATSRR-------KSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLL 743
            |....|::..|.:.       :.|:.....:....|...:.:|.|           ...|...|:
  Rat   600 LNIVETQEEETVKEDCRELFLEGDDHLMEEAQQPNIDQEVLLDPM-----------LVEDYDSLI 653

  Fly   744 KNLDDWTFDVFALTE---AASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRN 805
            :.:.:|.|.:|.|.|   ..||:::..|.|.||...|.:..|||.......:...:|.|   ||:
  Rat   654 EKMSNWNFQIFELVEKMGEKSGRILSQVMYTLFQDTGLLETFKIPTQEFMNYFRALENG---YRD 715

  Fly   806 -PYHNNLHAVDVMQTIHY-------------------------CLCNTGLMNWLTD--------- 835
             ||||.:||.||:..:.|                         ...::|.:.:|:.
  Rat   716 IPYHNRVHATDVLHAVWYLTTRPIPGLQQLHNNHETETKADSDARLSSGQIAYLSSKSCCIPDKS 780

  Fly   836 ----------LEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRL-L 889
                      ||:.|..:||.:|||:|.|.||.|.|.:.:..|:|||||:|||||||::::.| |
  Rat   781 YGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYL 845

  Fly   890 REDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQ---QMKAMRQLLTLQ----EATIDKQKV 947
            ...|||.|.:|...||:..|.||||.:|.||:..||:   :..|....:...    .:..|:..|
  Rat   846 SRPEYNFLLNLDHMEFKRFRFLVIEAILATDLKKHFEFLAEFNAKANDVNSNGIEWSSENDRLLV 910

  Fly   948 LSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFID 1012
            ..:.:...||:.|||...:|.|||..::.||:.|||.|..||||.||..||::..:|:.|..||.
  Rat   911 CQVCIKLADINGPAKDRDLHLRWTEGIVNEFYEQGDEEATLGLPISPFMDRSSPQLAKLQESFIT 975

  Fly  1013 FIVEP------SMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMD 1071
            .||.|      :.|::                  |...:|.|...::.::.    .:.......|
  Rat   976 HIVGPLCNSYDAAGLL------------------PGQWIEAEEGDDTESDD----DDDDDDDDDD 1018

  Fly  1072 KPRDHRTEAKTTAAECLARKSVTGTTASKFNIPKPW-------LTC-----LVENKRIWKEQAVK 1124
            ...|...|..:...|          |....| |||.       :.|     |.||.:||||...:
  Rat  1019 DDDDDDEELDSDDEE----------TEDNLN-PKPQRRKGRRRIFCQLMHHLTENHKIWKEIIEE 1072

  Fly  1125 DAEARALATAAEEAAAAAAAEAEESKPETETADGEQSE 1162
            :.:.:|..... :...|:..:|:|.: ..|.||.|:.:
  Rat  1073 EEKCKAEGNKL-QVDNASLPQADEIQ-VIEEADEEEEQ 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	9/62 (15%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	90/276 (33%)
Pde3b	NP_058925.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		Interaction with RAPGEF3. /evidence=ECO:0000250	1..32
		DUF3488	145..>264	CDD:403269	23/100 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..448		13/57 (23%)
		Interaction with PIK3R6. /evidence=ECO:0000250	421..445		9/28 (32%)
		PDEase_I	718..992	CDD:395177	90/291 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920