DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde1c and Pde6b

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_001099494.1	Gene:	Pde6b / 289878	RGDID:	1311039	Length:	856	Species:	Rattus norvegicus

Alignment Length:	806	Identity:	181/806 - (22%)
Similarity:	288/806 - (35%)	Gaps:	207/806 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 PSSPNATNYLADNIQISSANLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGDTDIPQESGHSFE 406
            |.:...|:|:..||      || |.::.|:|..  ..:.::|...|..|...|.|:       |.
  Rat   162 PFADELTDYVTKNI------LS-TPIMNGKDVV--AVIMAVNKLDGPCFTSEDEDV-------FT 210

  Fly   407 TPSNMSFTAGQWDTESLPPVDTPDALNKAAGRIRSLLRRMDHETVAYEDMQRNLHYAARVLEAVF 471
            ...|.:       |.:|.........|....|.:.||...:.......|::|..|.|...:.|.
  Rat   211 KYLNFA-------TLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAY- 267

  Fly   472 IDESREGCNGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESR 536
                          |||.|:|.|..|..::.       ...:..|...|..
  Rat   268 --------------LNCDRYSVGLLDMTKEK-------EFFDVWPVLMGEA-------------- 297

  Fly   537 TKGVSQAPQTHSGPTGPPSNTSSETIAQPAPKLQPALETVRESVMEE-SPSKDPGDKGPPPPAST 600
                    |.:|||..|...                 |.|...|::. ...|:.....|.|||..
  Rat   298 --------QPYSGPRTPDGR-----------------EIVFYKVIDYILHGKEDIKVIPTPPADH 337

  Fly   601 STLTSQTTTSSSATAEP-------SAKAAES---QAGSAGSSG-----SCSNPAAVHRQRRLRTP 650
            ..|||...|   ..||.       :|.|.|.   |.|....||     ..|.|....::..:...
  Rat   338 WALTSGLPT---YVAESGFICNIMNASADEMFNFQEGPLDESGWVIKNVLSMPIVNKKEEIVGVA 399

  Fly   651 TWARSMSTNKTRLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIR 715
            |:   .:....:..|:.||:               |..:.|:.:..|...:|...|...:.:  |
  Rat   400 TF---YNRKDGKPFDDQDEV---------------LMESLTQFLGWSVLNTDTYDKMNKLEN--R 444

  Fly   716 AGIFVDRM--YRRVSSSALTAFPPDVVRLLKNLDD-----------------WTFDV----FALT 757
            ..|..|.:  :.|.....:....|...||.|...|                 ..||:    |:..
  Rat   445 KDIAQDMVLYHVRCDKDEIQEILPTRDRLGKEPADCEEDELGKILKEELPGPTKFDIYEFHFSDL 509

  Fly   758 EAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHY 822
            |....::|| ...:::...|.:.||:|...:|..||..|.:.|.|.  .|||..|..:|.||:..
  Rat   510 ECTELELVK-CGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRI--TYHNWRHGFNVAQTMFT 571

  Fly   823 CLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFR 887
            .|....|.::.||||.||.:.|.|.||.:|.||.|.:.:.|.:..|.|:.. ::||.||......
  Rat   572 LLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGS-SILERHHLEFGKF 635

  Fly   888 LLREDEYNILSHLSREEFRELRGLVIEMVLGTDM----------------TNHFQQMKAMRQLLT 936
            ||.|:..||..:|:|.:...:..|:...::.||:                :.:::..|:..:.|:
  Rat   636 LLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDKKSWVEYLS 700

  Fly   937 LQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKE-LGLPFSPLCDRNN 1000
            |:  |..|:.|:::::..||:|...|.|.|..:..:|:..||:.|||||:. |.....|:.|||.
  Rat   701 LE--TTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNK 763

  Fly  1001 TL-VAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNS 1064
            .. :.:.|:.||||:                           .|.|..|.:..          :.
  Rat   764 AAELPKLQVGFIDFV---------------------------CTFVYKEFSRF----------HE 791

  Fly  1065 GITPSMDKPRDHRTEAKTTAAECLAR 1090
            .|.|..|:.:::|.|.|..|.|..|:
  Rat   792 EILPMFDRLQNNRKEWKALADEYEAK 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	9/55 (16%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	70/236 (30%)
Pde6b	NP_001099494.1	GAF	71..230	CDD:214500	19/90 (21%)
		GAF	252..439	CDD:214500	51/268 (19%)
		PDEase_I	556..801	CDD:278654	76/284 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920