DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde1c and Pde4d

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_006517706.1	Gene:	Pde4d / 238871	MGIID:	99555	Length:	803	Species:	Mus musculus

Alignment Length:	817	Identity:	219/817 - (26%)
Similarity:	356/817 - (43%)	Gaps:	178/817 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 LPPVDTPDALNKAAGRIRSL-LRRMDHETVAYEDMQRNLHYAARVLEAVFIDESREGCNGNCKNL 486
            |||...|....:  ||..|. ..|:.|.  .|.|.:|.|:..|....:..::      .|:...|
Mouse    77 LPPPPPPPGATR--GRYASSGASRVRHR--GYSDTERYLYCRAMDRTSYAVE------TGHRPGL 131

  Fly   487 NCSRHSHGRDDQ---QQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKG-VSQAPQTH 547
            ..||.|.....|   :.|.:|             |..||.:|    .|.:.|...| :.||...|
Mouse   132 KKSRMSWPSSFQGLRRFDVDN-------------GTSAGRSP----LDPMTSPGSGLILQANFVH 179

  Fly   548 S----------------GPTGPPSNTS-------SETIAQPAPKLQPALETVRE------SVMEE 583
            |                .|.....|:|       .:.|..|..::..:|.|||.      ::.:.
Mouse   180 SQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDR 244

  Fly   584 SPSKDPGDKGP---PPPASTSTLTSQTTTS-SSATAEPSAKAAESQAGSAGSSGSCSNPAAVHRQ 644
            :|||    :.|   .|..:.:|:|.:.... :|.|.|              ....|     :.:.
Mouse   245 APSK----RSPMCNQPSINKATITEEAYQKLASETLE--------------ELDWC-----LDQL 286

  Fly   645 RRLRTPTWARSMSTNKTR--LADEDDELSEVQPDAVPPEVREWLASTFTR-----QMATSRRKSD 702
            ..|:|......|::||.:  |..|...|||:....  .:|.|::::||..     ::.:..:|..
Mouse   287 ETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSG--NQVSEYISNTFLDKQHEVEIPSPTQKEK 349

  Fly   703 EKPKFRSVAHAIRAGIFVDRMYRRVSSSALT--AFPPDVVR------LLKNLDD---WTFDVFAL 756
            ||.| |.::.       :..:.:.:.||:||  ..|...|:      |.|.|:|   |...||.:
Mouse   350 EKKK-RPMSQ-------ISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRI 406

  Fly   757 TEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIH 821
            .|.:..:.:..:.:.:|.....:..|||....|..:|..:|:.| .....||||:||.||:|:.|
Mouse   407 AELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHY-HADVAYHNNIHAADVVQSTH 470

  Fly   822 YCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASF 886
            ..|....|....|||||.|::.|:.:||.:|.|.:|.|.:.:.||.||:|||.:||||||.:..|
Mouse   471 VLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF 535

  Fly   887 RLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEAT---------- 941
            :||:|:..:|..:|::::.:.||.:||::||.|||:.|...:..::.::..::.|
Mouse   536 KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNY 600

  Fly   942 IDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAES 1006
            .|:.:||..::||.|:|:|.|...::.:||..::||||||||.|:|.|:..||:||::|..|.:|
Mouse   601 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKS 665

  Fly  1007 QICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMD 1071
            |:.|||:||.|.....:|:       :.|..:....||.::.....||      ||.|. :|:.|
Mouse   666 QVGFIDYIVHPLWETWADL-------VHPDAQDILDTLEDNREWYQST------IPQSP-SPAPD 716

  Fly  1072 KPRDHRTEAKTTAAECLARKSVTGTTASKFNIPKPWLT----CLVENKRIWKEQAVKD---AEAR 1129
            ...:.|                .|.| .||...   ||    |..:.::....|..:|   ::::
Mouse   717 DQEEGR----------------QGQT-EKFQFE---LTLEEDCESDTEKDSGSQVEEDTSCSDSK 761

  Fly  1130 ALAT---------AAEEAAAAAAAEAEESKPETETAD 1157
            .|.|         ..|:....|.|| |||:|||...|
Mouse   762 TLCTQDSESTEIPLDEQVEEEAVAE-EESQPETCVPD 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	13/60 (22%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	92/228 (40%)
Pde4d	XP_006517706.1	PDE4_UCR	218..334	CDD:375549	30/140 (21%)
Pde4d	XP_006517706.1	PDEase_I	456..697	CDD:365964	94/247 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920