DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde1c and Pde1a

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_001153054.1	Gene:	Pde1a / 18573	MGIID:	1201792	Length:	545	Species:	Mus musculus

Alignment Length:	519	Identity:	242/519 - (46%)
Similarity:	325/519 - (62%)	Gaps:	59/519 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   662 RLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRR 726
            ||.|.:||||::|.|:||.|||:||||||||:|...::|.:|||||||:.||::|||||:||||:
Mouse    73 RLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMMKKKPEEKPKFRSIVHAVQAGIFVERMYRK 137

  Fly   727 VSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEA 791
            ........:|..|:..||.:|.|:||||||.||:....:|::.||||.||..|::|||....|.|
Mouse   138 NYHMVGLTYPAAVIVTLKEVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIA 202

  Fly   792 FLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTT 856
            |...:|.||.:::|||||.:||.||.||:||.:.:||:|:|||:|||.|.:.||.:|||||||||
Mouse   203 FAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTT 267

  Fly   857 NNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDM 921
            ||||:.:.|:.|:|||||:||||||.||::||::|:|.|||.:||::::|:||.|||||||.|||
Mouse   268 NNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDM 332

  Fly   922 TNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEK 986
            :.||||:|.:|..|...|. ||:.|.:||:||..|||||||.|.:|:||||.|:||||.|||.|.
Mouse   333 SGHFQQIKNIRNSLQQPEG-IDRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEA 396

  Fly   987 ELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTA 1051
            ||||||||||||.:|:||:|||.||||||||:..:::|..|.|:.|           |:|..:.:
Mouse   397 ELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIP-----------LIEEASKS 450

  Fly  1052 NSTTNSAIVIPNSGITPSMDKPRDHRTEAKTTAAECLARKSVTGTTASKFNIP---------KPW 1107
            .|:        |.|.:.|......|       .|:.|.|.:..|:.......|         |.:
Mouse   451 QSS--------NYGASSSSTMIGFH-------VADSLRRSNTKGSVCDGSYAPDYSLSAVDLKSF 500

  Fly  1108 LTCLV----ENKRIWKEQAVKDAEARALATAAEEAAAAAAAEAEESKPETETADGEQSEPAAEP 1167
            ...||    :||..|||                   .||..|.:..|...|..:.|:......|
Mouse   501 KNNLVDIIQQNKERWKE-------------------LAAQGELDLHKNSEELGNTEEKHADTRP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	35/55 (64%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	137/218 (63%)
Pde1a	NP_001153054.1	Calmodulin-binding	24..44
		PDEase_I_N	77..133	CDD:369905	35/55 (64%)
		PDEase_I	218..434	CDD:365964	136/216 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545		3/18 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I1358
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21043
Inparanoid	1	1.050	526	1.000	Inparanoid score	I1227
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	1	1.000	-	-		FOG0001902
OrthoInspector	1	1.000	-	-		otm43157
orthoMCL	1	0.900	-	-		OOG6_100946
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.970