DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde1c and pde-3

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_001293571.1	Gene:	pde-3 / 183981	WormBaseID:	WBGene00008443	Length:	693	Species:	Caenorhabditis elegans

Alignment Length:	770	Identity:	193/770 - (25%)
Similarity:	296/770 - (38%)	Gaps:	200/770 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 SANLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGDTDIPQESGHSFETPSNMSFTAGQWDTESL 423
            |..|| .||...||:|..:...|   ||.....||.|  .|.||..               :..|
Worm    47 SPRLS-AEMRKNRDTATSSPASS---GVSIQQRRGST--TQNSGVG---------------SIGL 90

  Fly   424 PPVDTPDALNKAAGRIRSLLRRMDHETVAYEDMQRNLHYAARVLEAVFIDESREGCNGNCKNLNC 488
            |.:         .||.|.::        :...|||..|.|.|        :.|.....|..:||.
Worm    91 PVL---------GGRGRGVM--------SDGHMQRTFHEAMR--------QRRTSLPANSLSLNG 130

  Fly   489 SRHSHGRDDQQQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGVS----QAPQTHSG 549
            ::.:               ..||.||.  |..|.:....:...::.|..:.|:    |.|.
Worm   131 AKVT---------------GSSLSEAK--GLIADMLMNKELPGNVASCLRAVTMLLEQRPL---- 174

  Fly   550 PTGPPSNTSSETIAQPAPKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSAT 614
                |.|........|             ||:|.....:....|...| ..|.:|..|.|  |||
Worm   175 ----PLNGLLNDFGLP-------------SVVENPYGGESMVVGASKP-RISNITFSTVT--SAT 219

  Fly   615 AEPSAKAAESQAGSAGSSGSCSNPAAVHRQRRLRTPTWARSMSTNKTRLADEDDELSEVQPDAVP 679
            ..|:..|                           .|..|||.|..||..:..::...|...|.:
Worm   220 GLPTVPA---------------------------EPNKARSSSYWKTEASPSNNNEHETPVDLL- 256

  Fly   680 PEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALTAFPPDVVRLLK 744
                        |:::.||::|               |..||.:...:..........|....|.
Worm   257 ------------RKISVSRKES---------------GTHVDTVVTTIDGQRYDTRELDTDPDLA 294

  Fly   745 NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHN 809
            ....|:|.:|.::......::..:.|.:|.:......||::|.....|.|.:|:||  :..||||
Worm   295 ETAVWSFPIFQMSRKHPQTILSRLTYNIFQQAELFRIFKVSPIKFFNFFHALEKGY--WEIPYHN 357

  Fly   810 NLHAVDVMQTIHYCLC-------------------------NTGLMNWLTDLEIFASLLAALLHD 849
            .:||.||:...:|...                         ::.:|:.|:.||:.|...||.:||
Worm   358 RIHAADVLHGCYYLSAHPVRSTFLTPKTPDSVLTPPHPHHQHSSIMSQLSTLELMALFTAAAMHD 422

  Fly   850 YEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIE 914
            |:|.|.||.|.|....:.|:|||||:|||||||:.|::||.:.|.:.:.:|...|.:..|.||:|
Worm   423 YDHPGRTNAFLVQVEDKKAILYNDRSVLENHHAAESWKLLNKPENHFIENLDPAEMKRFRYLVLE 487

  Fly   915 MVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVL--SLVLHCCDISHPAKQWGVHHRWTMLLLEE 977
            .:|.||:..||:.:....:.||..:..::..::|  .|::...||:.|.|.:|:|.:||..:.||
Worm   488 YILATDLKQHFEIIMTFTERLTEIDVQVETDRLLIGKLLIKMADINSPTKPYGLHRQWTDRICEE 552

  Fly   978 FFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIAP-MNKSKP 1041
            |:.|||.|:..|||.:|..||.:..||:.|..||..:|.|   :.:.|.|..|.||.| ::.|:.
Worm   553 FYEQGDDERRRGLPITPYMDRGDAQVAKLQDSFIAHVVSP---LATAMNECGLLPILPGLDTSEL 614

  Fly  1042 ATLVEH-------------------ETTANSTT--NSAIVIPNSGITPSMDKPRD 1075
            ...:||                   :.|.|..|  |..|...::..:.|.|..||
Worm   615 IINMEHNHRKWKEQIELENGGSYEAQITCNGGTAVNGVIEEESASTSDSPDPRRD 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	8/55 (15%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	84/245 (34%)
pde-3	NP_001293571.1	PDEase_I	355..610	CDD:278654	90/257 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920