DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde1c and pde-1

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	NP_493343.1	Gene:	pde-1 / 173200	WormBaseID:	WBGene00011433	Length:	664	Species:	Caenorhabditis elegans

Alignment Length:	838	Identity:	296/838 - (35%)
Similarity:	421/838 - (50%)	Gaps:	189/838 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 SNSGPAASAAVKMQPSSPNATNYLADNIQISSANLSQTEMVVGRDSADYTAMHSINVGVGNSFLR 392
            |:.|...||...::||:.:|:....|    |...|...:::..||..:.|:..||.:
Worm     8 SSCGCFRSAFCLLKPSTSSASEEHGD----SDKKLLSVQLITPRDEEEQTSSRSIKI-------- 60

  Fly   393 GDTDIPQESGHSFETPSNMSFTAGQWDTESLPPVDTP--DALNKAAGRIRSLLRRMDHETVAYED 455
                                           ||:|..  |....|....|:..||    |.....
Worm    61 -------------------------------PPLDLNGLDCKKNAVAARRAGRRR----TSEGGG 90

  Fly   456 MQRNLHYAARVLEAVFIDESREGCNGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEASPGGAG 520
            ::...|:|..||:            |..:.::..|:       |::.:||:.:|  ||..|....
Worm    91 VRGKGHFAEVVLD------------GLQRPVSLLRN-------QKEKSNSDDNC--QEKEPTSPS 134

  Fly   521 AGVTPGADNQDSIESRTKGVSQAPQTHSGPTGPPSNTSSETIAQPAPKLQPALETVRESVMEESP 585
            :......||..::||..|......|.:||                    |..||.::.::
Worm   135 SSRKKSYDNAPALESLEKLRYILHQLNSG--------------------QLPLEDLKRNI----- 174

  Fly   586 SKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQAGSAGSSGSCSNPAAVHRQRRLRTP 650
                                          |.:|...|:              |.:...|
Worm   175 ------------------------------EYAALVLET--------------AYMDETR----- 190

  Fly   651 TWARSMSTNKTRLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIR 715
                       |:.||||:|:||.|:.||.|||||||:|||||.|..:|   :||||:|||:|||
Worm   191 -----------RICDEDDDLAEVTPETVPDEVREWLAATFTRQNAGKKR---DKPKFKSVANAIR 241

  Fly   716 AGIFVDRMYRRVSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIH 780
            .|||.::::|: ........||::..|:|.:..|:|..|.|.|.:.|..:|||.:|||||||.:.
Worm   242 TGIFFEKLFRK-QQVVQCPIPPEIAELMKEVCTWSFSPFQLNEVSEGHALKYVGFELFNRYGFMD 305

  Fly   781 KFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAA 845
            :||:....||.:|..:|.||.::.|||||.:||.||.|:.|:.|..|||.|.|.|||:.|.|..|
Worm   306 RFKVPLTALENYLSALEVGYSKHNNPYHNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGA 370

  Fly   846 LLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRG 910
            |:|||||||.|||||:.|.|:.|:|||||:||||||.|:.|||::||:.|||:||:|:|::|||.
Worm   371 LIHDYEHTGHTNNFHIQSQSQFAMLYNDRSVLENHHVSSCFRLMKEDDKNILTHLTRDEYKELRN 435

  Fly   911 LVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLL 975
            :|||:||.|||:.||.|:|.|:.:|:|.|. |||.|.|.|::|.||||||||.|.:|.|||..:|
Worm   436 MVIEIVLATDMSTHFMQIKTMKSMLSLPEG-IDKNKALCLIVHACDISHPAKPWNLHERWTEGVL 499

  Fly   976 EEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVMSDMLELILAPIA---PMN 1037
            ||||||||||..:|||:||||||:...||:|||.||||||||:|.|..::|..::.|:.   |.:
Worm   500 EEFFRQGDLEASMGLPYSPLCDRHTVHVADSQIGFIDFIVEPTMVVCGELLVKMVEPLVSLPPTD 564

  Fly  1038 KSKPATLVEHETTANSTTNSAIVIP---NSGITPSMDKPRDHRTEAKTTAAECLARKSVTGTTAS 1099
            ...|.::...:.  .|.:|:...:|   ||..:||                   :.:.:....|.
Worm   565 SLFPPSVDGGDD--KSPSNALSPLPDLRNSSTSPS-------------------SIRRIPLNYAG 608

  Fly  1100 KFNIPKPWLTCLVENKRIWKEQAVKDAEARALATAAEEAAAAAAAEAEESKPETETAD 1157
            |.:||.||:..|.|||..|||:|.|:.|.|.:..|||  |.|||.:.||:|....|.:
Worm   609 KLDIPTPWMKFLHENKAHWKERAAKEEEERKIKEAAE--AEAAAKQVEENKENGVTTN 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	36/55 (65%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	135/218 (62%)
pde-1	NP_493343.1	PDEase_I_N	195..248	CDD:285672	36/55 (65%)
pde-1	NP_493343.1	PDEase_I	332..558	CDD:278654	137/226 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I841
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	467	1.000	Inparanoid score	I847
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439875at33208
OrthoFinder	1	1.000	-	-		FOG0001902
OrthoInspector	1	1.000	-	-		oto17776
orthoMCL	1	0.900	-	-		OOG6_100946
Panther	1	1.100	-	-	LDO	PTHR11347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4957
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.000