DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde1c and Pde5a

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_006233322.1	Gene:	Pde5a / 171115	RGDID:	620995	Length:	865	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	95/340 - (27%)
Similarity:	154/340 - (45%)	Gaps:	21/340 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   731 ALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHR 795
            ||.|......:.|| :.|::|..|.|::..:.    .....:|.....:..|::...:|..::..
  Rat   532 ALAAAVVPSAQTLK-ITDFSFSDFELSDLETA----LCTIRMFTDLNLVQNFQMKHEVLCRWILS 591

  Fly   796 VEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFH 860
            |::.| |....|||..||.:..|.:...|....:.|.|||||..|.|:|||.||.:|.|..|::.
  Rat   592 VKKNY-RKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYI 655

  Fly   861 VMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHF 925
            ..|....|.|| ..:.:|:||......:|......|||.||.||::....::.:.:|.||:..:.
  Rat   656 QRSEHPLAQLY-CHSTMEHHHFDQCLMVLNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYI 719

  Fly   926 QQMKAMRQLLTLQEAT----IDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLE- 985
            ::.....:|:...|.:    :.|:..|::::..||:|...|.|.:..|...|:..|||.|||.|
  Rat   720 KRRGEFFELIRKNEFSFEDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRER 784

  Fly   986 KELGLPFSPLCDR-NNTLVAESQICFIDFI----VEPSMGVMSDMLELILAPIAPMNKSKPATLV 1045
            |||.:..:.|.:| ....:...|:.|||.|    .|....|..|.|.|:..  ...|:.|...|.
  Rat   785 KELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCLPLLDG--CRKNRQKWQALA 847

  Fly  1046 EHE--TTANSTTNSA 1058
            :.:  |..|..:..|
  Rat   848 DQQEKTLLNGESGQA 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	72/228 (32%)
Pde5a	XP_006233322.1	GAF	154..311	CDD:214500
		GAF	337..503	CDD:214500
		PDEase_I	602..837	CDD:278654	74/237 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920