Protein Alignment Pde1c and Pde5a

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_006233322.1
• Gene: Pde5a / 171115
• RGDID: 620995
• Length: 865
• Species: Rattus norvegicus
• Alignment Length: 340
• Identity: 95/340 - (27%)
• Similarity: 154/340 - (45%)
• Gaps: 21/340 - (6%)

  Fly   731 ALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHR 795
            ||.|......:.|| :.|::|..|.|::..:.    .....:|.....:..|::...:|..::..
  Rat   532 ALAAAVVPSAQTLK-ITDFSFSDFELSDLETA----LCTIRMFTDLNLVQNFQMKHEVLCRWILS 591

  Fly   796 VEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFH 860
            |::.| |....|||..||.:..|.:...|....:.|.|||||..|.|:|||.||.:|.|..|::.
  Rat   592 VKKNY-RKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYI 655

  Fly   861 VMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHF 925
            ..|....|.|| ..:.:|:||......:|......|||.||.||::....::.:.:|.||:..:.
  Rat   656 QRSEHPLAQLY-CHSTMEHHHFDQCLMVLNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYI 719

  Fly   926 QQMKAMRQLLTLQEAT----IDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLE- 985
            ::.....:|:...|.:    :.|:..|::::..||:|...|.|.:..|...|:..|||.|||.|
  Rat   720 KRRGEFFELIRKNEFSFEDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRER 784

  Fly   986 KELGLPFSPLCDR-NNTLVAESQICFIDFI----VEPSMGVMSDMLELILAPIAPMNKSKPATLV 1045
            |||.:..:.|.:| ....:...|:.|||.|    .|....|..|.|.|:..  ...|:.|...|.
  Rat   785 KELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCLPLLDG--CRKNRQKWQALA 847

  Fly  1046 EHE--TTANSTTNSA 1058
            :.:  |..|..:..|
  Rat   848 DQQEKTLLNGESGQA 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497
		PDEase_I	807..1027	CDD:459723	72/229 (31%)
Pde5a	XP_006233322.1	GAF	154..311	CDD:214500
		GAF	337..503	CDD:214500
		PDEase_I	602..836	CDD:459723	74/236 (31%)