Protein Alignment Pde1c and Pde11

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_061516499.1
• Gene: Pde11 / 1275495
• VectorBaseID: AGAMI1_005351
• Length: 1235
• Species: Anopheles gambiae
• Alignment Length: 1268
• Identity: 258/1268 - (20%)
• Similarity: 430/1268 - (33%)
• Gaps: 343/1268 - (27%)

  Fly    97 VGSPGTMSSSLGKAGRLNS-----SRYPSGGAGAIGL-SVMGNLVGTTTRKCVLTLDGYSYVIVA 155
            :|:..|::..||.  .|.|     ||.|:...|.:|| :.:|:..|                  .
Mosquito    84 LGTNWTLARKLGL--HLRSIEEPQSRMPTEQGGTVGLDATLGSRAG------------------V 128

  Fly   156 STPESLPSKRD----------------EASGGPGSSGGTSGAATSSSSS-------------GGG 191
            ..|..||...:                .:|...||:.|:||:.....:|             .|.
Mosquito   129 PLPLQLPPHSNLHHHHPHHNHHSHHHANSSSSSGSNSGSSGSHHPPPNSHHHHHHHHHHHQQTGA 193

  Fly   192 AASGAASGSVGPASGTATGTGSASGGAGGV----------------------------------- 221
            ...|..:|  ||..|.....|.|.||.||.
Mosquito   194 LGCGGCTG--GPTQGAQGSAGGAIGGGGGYDAEFARMESWLDENPEFMQDYFIRKATRNMVDGWL 256

  Fly   222 ---STPAQEAASPTVSELSGSGSNATINGQVARHGSLTIIRRTNSRNFTQFDGQLASPSSTACSS 283
               :||...||:...|...|:...::..|   ..|:.|.:|:.::..|.:  |.|..|    ..:
Mosquito   257 VSHATPVTTAANSVDSPTHGTNQPSSSRG---GSGATTPVRKISAHEFER--GGLLKP----IVN 312

  Fly   284 TAPGIGFAQTPLSEPLAERLSFRASGGSNGSASAGDSRSSNQGPSNSGPAASAAVKMQPSSPNAT 348
            |..|     ||         :|.:....|.|:::|.::                     ..||..
Mosquito   313 TIDG-----TP---------TFLSISPQNESSASGSTQ---------------------CCPNGV 342

  Fly   349 NYLADN---IQISSANLSQT-------EMV--VGRDSADYTAMHSI--NVGV------------- 386
            .|...|   :::|...|.|.       |:|  :..|....:..|.|  ||.:
Mosquito   343 TYCGANLRPLRLSRNELKQLDERELIFELVKDICNDLDVRSLCHKILQNVSILLNADRGSLFLVQ 407

  Fly   387 GNSFLRGDTDIPQESGHSFETPSNMSFTAGQ--------WDT-------ESLPPVDTPDALNKAA 436
            |.|...||..........|:..||.:....:        |.|       ||..||:.|||...
Mosquito   408 GKSTCGGDNTKKCLVSKLFDVCSNSTLEEMEQQDEVKVAWGTGIAGHVAESGEPVNIPDAYQD-- 470

  Fly   437 GRIRSLLRRMDHETVAYEDMQRNLHYAARVLEAVFIDESREGCNGNCKNLNCSRHSHGRDDQQQD 501
                   .|.:.|.    |:|..  |..:.|..:.|.::.....|..:.:|          :|.|
Mosquito   471 -------ERFNREI----DVQTG--YRTKALLCMPIKDASGDVVGVAQVIN----------KQGD 512

  Fly   502 NNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGV--SQAPQTHSGPTGPPSNTSSETIAQ 564
            ...|.....:..:.....|.|:.    |....|.....|  :|.....:.......:|....:.:
Mosquito   513 QCFSTADEKIFSSYLQFCGIGLR----NAQLYEKSQLEVKRNQVLLDLARMIFEEQSTIEHMVFR 573

  Fly   565 PAPKLQPALETVRESVM---EESP--------------SKDPGDKGPPPPASTSTLTSQTTTSSS 612
            ....:|..::..|..::   |.|.              |.:.||      |.||...|:...:..
Mosquito   574 ILTHMQSLIQCQRVQILLVHEASKGSFSRVFDFEANDLSGEDGD------ARTSPFESRFPINVG 632

  Fly   613 ATAEPSAKAAESQAGSAGSSGSCSNPAAVHRQRRLRTPTWARSMS-TNKTRLADE-DDELSEVQP 675
            .|            |...::|...|....:...|. .|:....:: .:||.|... .:.||::
Mosquito   633 IT------------GYVATTGETVNICNAYEDDRF-DPSVDEGLNFRHKTILCMAIKNSLSQI-- 682

  Fly   676 DAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRR-------------V 727
            ..|...:.::...|||        |:||. ...:.|.....||....||.:             |
Mosquito   683 IGVIQLINKFDDLTFT--------KNDEN-FVEAFAIFCGMGIHNTHMYEKAIIAMAKQSVTLEV 738

  Fly   728 SSSALTAFPPDVVRL--LK-------NLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFK 783
            .|...:|...|..||  ||       .|.|:.||...|.:   ...:| ....:|.....:.:|.
Mosquito   739 LSYHASATIDDAYRLRQLKVPSSAFFKLYDFKFDDLTLDD---DHTLK-ACLRMFLDLDLVERFH 799

  Fly   784 IAPGILEAFLHRVEEGYCRYRN-PYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALL 847
            |...:|..:|..|::   .||| .|||..||.:|.|.:...|.:|.......::|..|.::|.|.
Mosquito   800 IEYEVLCRWLLSVKK---NYRNVTYHNWRHAFNVTQMMFAILTSTQWWKIFGEIECLALIIACLC 861

  Fly   848 HDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLV 912
            ||.:|.||.|:|.:.:.|..|.||: .:.:|:||......::......|||::|.|::..:..::
Mosquito   862 HDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMIINSPGNQILSNMSSEDYSRVIRVL 925

  Fly   913 IEMVLGTDMTNHFQQMKAMRQL------LTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWT 971
            .:.:|.||:..:|::..|...|      ::..:|...:..:.::.:..||:|...|.|.:..|..
Mosquito   926 EDAILSTDLAVYFRKRGAFLNLVEPASEMSSWQAEEPRSLLRAMSMTVCDLSAITKPWEIEKRVA 990

  Fly   972 MLLLEEFFRQGDLEK-ELGL-PFSPLCDRNNTLVAESQICFIDFIVEP---SMGVMSDMLELILA 1031
            .|:..|||.|||:|: ||.: |...:.......:...|:.|||.|..|   :...:||.|..::.
Mosquito   991 DLVSSEFFEQGDMERQELNITPIDIMNREKEDQLPMMQVGFIDSICIPIYEAFATLSDKLTPLID 1055

  Fly  1032 PIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRD--HRTEAKTTAAEC----LAR 1090
            .:.. ||.....|.:....|.:..|:.....|:..:|..|...|  |:.:.   ..||    |..
Mosquito  1056 GVRE-NKQHWIELAQSAKEAYANNNNTSENNNNNKSPCTDHAEDDGHQQDG---VVECVGSPLGS 1116

  Fly  1091 KSVTGTTASKFNIPKPWLTCLVENKRIWKEQAVKDAEARALATAAEEAAAAAAAEAEESKPETE- 1154
            .:..|||..|.:: :|..|....:..|...::......|::   .|:......|:...|.|..:
Mosquito  1117 PASNGTTPRKLSL-EPDCTDSGHHHSIGSHESATTNSCRSI---KEKIVGRLGADLASSPPYADK 1177

  Fly  1155 -------------------------TADGEQSE 1162
                                     ::||:.||
Mosquito  1178 PSFLVVGQKGNGWVNGDKVRLIRLSSSDGKTSE 1210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	13/60 (22%)
		PDEase_I	807..1027	CDD:459723	64/230 (28%)
Pde11	XP_061516499.1	None