DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde1c and AgaP_AGAP000236

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_003436945.1	Gene:	AgaP_AGAP000236 / 1272025	VectorBaseID:	AGAP000236	Length:	1365	Species:	Anopheles gambiae

Alignment Length:	1473	Identity:	358/1473 - (24%)
Similarity:	509/1473 - (34%)	Gaps:	471/1473 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GDTLDETPPTRRDKPQTLNIGQEEQGSDPASGNTSSPVSSIAIPAARVPRHRLRHADRDQKRDHS 66
            |.|..:| ||.|..|.|:...:..:..|.|.              |:.|      ||.|...|..
Mosquito    53 GPTKKKT-PTVRPLPVTIFGAKRNETLDGAK--------------AKKP------ADDDDDDDDG 96

  Fly    67 SDGLVS---------SGELRDEFMGID--AQPRRESLNSCEVGSPGT----MSSSLGKAGRLNSS 116
            .||..|         .||:||| :|.|  .|..|.:..|.....|..    .|||...|.|....
Mosquito    97 GDGGDSDDGPGEEEEEGEVRDE-VGQDESKQLLRHAAGSALAPHPAVPHAPRSSSSSNATRDGPG 160

  Fly   117 RYPSGGAGAIGLSVMGNLVGTTTR--KCVLTLDGYSYVIVASTPESLPSKRDEASGGPGSSGGTS 179
            |                  ..|.|  :|                 .||.:.|...||.|..||..
Mosquito   161 R------------------KATARLFRC-----------------CLPCRGDGGGGGSGGGGGGG 190

  Fly   180 GAATSSSSSGGGAA-------------SGAASG------------------------SVGPASGT 207
            |...|:.|||.||:             ||...|                        |:|..|||
Mosquito   191 GRGASARSSGSGASGETLKDTEKGALRSGTGRGRDRGDGVGRGERGRRGGGGGSVEESIGCGSGT 255

  Fly   208 ---------ATGTGSASGGAGGVSTPAQEAASPTVSELSGSGSNATINGQVARHGSLTIIRRTNS 263
                     |.|.|.:.||.||.:||....|..||  :||.|...|        ||||....|.:
Mosquito   256 GRADGTPESAAGVGDSGGGVGGTNTPGDAVAMATV--VSGDGKQTT--------GSLTTTTTTTT 310

  Fly   264 ----------RNFT----------------------------QFDGQLASPSSTACSSTAPGIGF 290
                      ||.|                            |.|.....|..   ....|..|.
Mosquito   311 TTILTGNGRPRNSTRGVLQASLAKQEEDDDEEADTDTEMQGQQDDSDAGVPPR---EMVGPEPGT 372

  Fly   291 AQTPLSEPLAERLSFRASGGSNGSASAGDSRSSNQGPS--NSGPAASAAVKMQP---------SS 344
            .|.  ..|.|..|....:|...||...|    ::|.|:  :.|.:|....::.|         .|
Mosquito   373 VQP--QHPYAIGLLAGGAGLMGGSGRPG----AHQRPAGRHRGTSAQQHPQLLPHIREERKRNGS 431

  Fly   345 PNAT--NYLADNIQISSANLSQTEMVVGRDSADYTAMHSINVG-----------------VGNSF 390
            .:||  ....|....|.:.:.:.|.....:..:..|..|:.||                 :.:.:
Mosquito   432 ADATVRREADDEADTSGSMMEEEEEEEDEEEEEARAGESLEVGRKEAADEEERDDDEQEEIDDGY 496

  Fly   391 LRGDTD----------IP--------QESG------------------HSFET------------ 407
            ...:.|          ||        |::|                  |:...
Mosquito   497 SADEDDSARRVLAVPLIPTVAGAGKYQQAGKPQQQLPPPHPKYHRNRRHTLANVRFMDNAEGSGS 561

  Fly   408 --PSN-MSFTAGQWDTES---LPPVD----TPDALNKAA--GRIRSLLRRMDHETVAYEDMQRNL 460
              ||. ||...|.....|   ||..|    .|.||..||  .|..|.|.|.|.:......:....
Mosquito   562 GPPSGVMSVVGGYTSRRSPLLLPSGDGGPGGPGALLSAALPQRRESFLYRSDSDFEISPKVSSVS 626

  Fly   461 HYAARVLEAVFIDESREGCNGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEASPG------GA 519
            ..|||             |:.|                   |:.|..|.| ..||.|      ..
Mosquito   627 LLAAR-------------CSAN-------------------NSGSGTSTS-NVASTGSGTTLTSG 658

  Fly   520 GAGVTPGADNQDSIESRTKGVSQAPQTHSGPTGPPSNTSSETIAQPAPKLQPALETVRESVMEES 584
            |.|||.|.....:...:.....:.|...|.....||::::..:...:..:..:..:.|.::|  |
Mosquito   659 GGGVTGGGSRDGAFHWKETSTLEEPAVLSSIASSPSSSATTVVGAASSTVVTSSTSERTTMM--S 721

  Fly   585 PSKDPGDKGPPPP----------ASTSTLTSQTTTSSSATAEPS----------AKAAESQAGSA 629
            .|...|..|....          ||..|:.|.....|||..|.|          |::||:..|||
Mosquito   722 GSGGGGSSGHHDDLIVTPFAQILASLRTVRSNLYALSSALPEESELATRRSSAGAESAETDPGSA 786

  Fly   630 GSSGSCSNPAAVHRQRRLRTPT-----WA----------RSMSTN-----KTRLADEDDELSEVQ 674
              :|..|.|......|:|.|.|     |.          ||:|..     |..|..|...|||..
Mosquito   787 --AGDDSQPDKDGDLRQLTTETIDELEWCLEQLETVQTHRSVSDMASLKFKRLLNKELSHLSESS 849

  Fly   675 PDAVPPEVREWLASTFT--------------------RQMATSRRKSDEKPKFRSVAH------A 713
            ...  .::.|::.:||.                    |....:.|.|:.....|.:.|      |
Mosquito   850 KSG--NQISEYICTTFLDKQQEPDVPSAPLVGSALIGRPTGAAGRMSEISGFKRPLQHTNSFSGA 912

  Fly   714 IRAGI--FVDRMYRRVSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRY 776
            ..||:  ..||:......:|..|...::..||..:|.|..|:|.:...:..:.:..|||.:|...
Mosquito   913 AGAGVTSLADRLPPYGVPTATAADEAELGGLLGQIDQWGVDIFRIGTLSGSRPLTAVAYTVFQDR 977

  Fly   777 GSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFAS 841
            .......|.|.:|.||:..||:.|.. .||:||:|||.||.|:.|..|.:..|....|.||:.|:
Mosquito   978 NIPRTLTIPPTVLLAFVSTVEDHYVA-DNPFHNSLHAADVTQSTHALLHSPALDGVFTPLEVCAA 1041

  Fly   842 LLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFR 906
            |:||.:||.:|.|.||.|.:.|.||.||:|||.:||||||.:.:|:|::.|:.|||.:|.:::..
Mosquito  1042 LVAACIHDVDHPGLTNQFLINSSSELALMYNDESVLENHHLAVAFKLMQNDDCNILRNLPKKQRA 1106

  Fly   907 ELRGLVIEMVLGTDMTNH---FQQMKAMRQ----------------------LLTLQEATIDKQK 946
            ..|.:||:|||.|||:.|   ...:|.|.:                      ||.|.::..|:.:
Mosquito  1107 TFRKMVIDMVLSTDMSKHMTLLADLKTMVETKKVAISGNQNPGESRSSGSGVLLRLLDSYTDRIQ 1171

  Fly   947 VLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFI 1011
            ||..::||.|:|:|.|...::.||...|:||||||||.|:..|:..||:|||.:..|..||:.||
Mosquito  1172 VLQNLVHCADLSNPTKPLPLYRRWVRRLMEEFFRQGDRERAAGMDVSPMCDRRSATVESSQVGFI 1236

  Fly  1012 DFIVEPSMGVMSDMLELILAPIAPMNKSKP-ATLVEHETTANSTTNSAIVIPNSGITPSMDKPRD 1075
            |:||.|.....::::             :| |..:......|.....|::.|.|  .||.:|..:
Mosquito  1237 DYIVHPLWEAWAELV-------------RPDAQDILDRLEENRAYYQALIPPPS--PPSHEKDEE 1286

  Fly  1076 HRTEAKTTAAECLARKSVTGTTASKFNIPKPWLTCLVENKRIWKEQAVKDAEARALATAAEEAAA 1140
            ...||:..|                              ||..|:|..:...       ||:.|.
Mosquito  1287 EEEEAEEAA------------------------------KREAKQQQQQQER-------AEQEAG 1314

  Fly  1141 AAAAEAEESKP------------ETETADGEQSEPAAEPADGA 1171
            :...|.:|..|            :...|:.::.|...||..||
Mosquito  1315 SKRNEQQEPMPIDPQALAARLRFQMTLAENDEEEDDLEPDGGA 1357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	15/83 (18%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	97/243 (40%)
AgaP_AGAP000236	XP_003436945.1	PDEase_I	1007..1263	CDD:278654	99/268 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X171
TreeFam	0	0.000	Not matched by this tool.
	3	2.920