Protein Alignment Pde1c and pde6a

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_002936750.3
• Gene: pde6a / 100489913
• XenbaseID: XB-GENE-988755
• Length: 866
• Species: Xenopus tropicalis
• Alignment Length: 885
• Identity: 182/885 - (20%)
• Similarity: 308/885 - (34%)
• Gaps: 267/885 - (30%)

  Fly   346 NATNYLADNIQISSANLSQTEMVVGRDS----------ADYTAMHSINVGVGNSFLRGDTDIPQE 400
            |.|..||..:...:.:.:..|.||..||          ..|.|.....|.|        :|:.|:
 Frog   103 NGTAELATRLFNVNKDATLDECVVVPDSEIVFPLDTGVLGYVAQSKKLVNV--------SDVTQD 159

  Fly   401 SGHSFETPSNMSFTAGQWDTESL---PPVDTPD------ALNKAAG---------------RIRS 441
            | |......|::    ::||:|:   |.::..|      |:||:.|               ...:
 Frog   160 S-HFCSFVDNLT----EYDTKSILAAPVLNGKDVVAVIMAVNKSDGTNFTKTDEEMFLKYLSFAN 219

  Fly   442 LLRRMDHETVAYE---------------------DMQRNLHYAARVLEAVFIDESREGCNGNCKN 485
            |:.::.|.:..:.                     |::|..|.|...:.|.
 Frog   220 LVLKVYHLSYLHNCETRRGQILLWSANKVFEELTDIERQFHKALYTVRAF--------------- 269

  Fly   486 LNCSRHSHGRDDQQQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKG--------VSQ 542
            |||.|:|.|..|.                                    ::||.        :.:
 Frog   270 LNCDRYSVGLLDM------------------------------------TKTKEFFDQWPILMGE 298

  Fly   543 APQTHSGPTGPPSNTSSETIAQPAPKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQT 607
            .| .:|||..|.....|             ...|.:.::.   .|:.....|.|||...:|.|:.
 Frog   299 VP-PYSGPKTPDGREIS-------------FYKVIDYILH---GKEEIKVIPNPPADHWSLVSKL 346

  Fly   608 TTSSSATAE----------PSAKAAESQAGSAGSSG-----SCSNPAAVHRQRRLRTPTWARSMS 657
               .|..||          .:.:..:.|.|....||     ..|.|....::..|...|:..
 Frog   347 ---PSYVAENGLICNIMNTSADEYFDFQKGPVDDSGWIMKNVLSMPIVNKKEEILGVATFYN--- 405

  Fly   658 TNKTRLADEDDELSEVQPDAVP-PEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVD 721
                            :.|..| .|:.|.|..:.|:.:..|...:|...|...:.:  |..|:.|
 Frog   406 ----------------RKDGKPFDEMDEVLTESLTQFLGWSVLNTDTYEKMNKLEN--RKDIYQD 452

  Fly   722 RMYRRVSSSALTAFPPDVVRLLKNLDDWT-----------FDVF--ALTEAASGQVVKY------ 767
            .:...|..|     ..::..:||..:.:.           :::.  .|.:....::.::
 Frog   453 MVNYHVKCS-----NDELQIILKTKEIYNRLPEECEEEELYEILQEELPDPTEAEIYEFHFSDLP 512

  Fly   768 --------VAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCL 824
                    .|.:::.....:.||.|...:|..||..|.:||.:.  .|||..|..:|.||:...|
 Frog   513 VSELFLVKCAIQIYYELEVVDKFHIPQEVLVRFLFSVSKGYRKI--TYHNWRHGFNVGQTMFTLL 575

  Fly   825 CNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLL 889
            ....|..:.||||..|.:.||..||.:|.||.|.:.:.||...|.|:.. ::||.||......||
 Frog   576 MTGNLKRYYTDLEAMAMVTAAFCHDIDHRGTNNLYQMKSGHPLAKLHGS-SILERHHLEFGKFLL 639

  Fly   890 REDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQK-------- 946
            :::..||..:|:|.::.....::...::.||:..:|:: :||.|.:..|..|...:|
 Frog   640 KDESLNIFQNLNRRQYDHAIHMMDIAIIATDLALYFKK-RAMFQKIVDQSQTFTSEKDWTEYMML 703

  Fly   947 -------VLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKEL--GLPFSPLCDRNNT- 1001
                   |:::::..||:|..||.|.:..:..:|:..||:.|||||:.:  ..|. |:.|||..
 Frog   704 EQTRKEIVMAMMMTACDLSAIAKPWDIQSKVALLVAAEFWEQGDLERTVLQQNPI-PMMDRNKAD 767

  Fly  1002 LVAESQICFIDFI----------VEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTN 1056
            .:.:.|..||||:          ..|.:..|.|.:         :|..|....:..|..|...|.
 Frog   768 ELPKLQCGFIDFVCTFVYKEFSRFHPEIQPMYDGI---------LNNKKEWKKLADEYDAKMKTL 823

  Fly  1057 SAIVIPNSGITPSMDKP----RDHR-----TEAKTTAAEC 1087
            ........||.|....|    |::.     |||...:..|
 Frog   824 EEDKQKKEGIQPPKQVPQPTVRENGGNVPVTEAAPQSKSC 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497	11/60 (18%)
		PDEase_I	807..1027	CDD:459723	73/247 (30%)
pde6a	XP_002936750.3	GAF	73..232	CDD:214500	29/141 (21%)
		GAF	254..441	CDD:214500	48/276 (17%)
		PDEase_I	558..802	CDD:459723	73/246 (30%)