Protein Alignment Pde1c and pde5aa

DIOPT Version :10

• Sequence 1: NP_001137817.1
• Gene: Pde1c / 34594
• FlyBaseID: FBgn0264815
• Length: 1173
• Species: Drosophila melanogaster
• Sequence 2: XP_009305135.1
• Gene: pde5aa / 100334568
• ZFINID: ZDB-GENE-100414-2
• Length: 922
• Species: Danio rerio
• Alignment Length: 307
• Identity: 85/307 - (27%)
• Similarity: 140/307 - (45%)
• Gaps: 20/307 - (6%)

  Fly   738 DVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCR 802
            |.:.||    |:.|..|.:::.|..|.|    ..:|.......:|||....|..::..|::.| |
Zfish   604 DTLSLL----DFGFSDFDMSQNAMTQAV----VRMFLDLNLPQEFKIDYKALCQWVLSVQKCY-R 659

  Fly   803 YRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSET 867
            ....|||..||:...|.:...|....|.:.|:.||:.|.::|:|.||.:|.|..|::...|....
Zfish   660 SNVVYHNWSHALRTAQCMFAMLQTKELKSNLSSLEVLALMIASLSHDLDHRGVNNSYIQRSNQPL 724

  Fly   868 ALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQ----M 928
            |.||. ::.||:||......:|......|||.||..|:.....::.:.:|.||:...|::    .
Zfish   725 AQLYG-QSSLEHHHYDMCLLILNNPGSQILSSLSVNEYMACLQMIEKNILATDLAIFFEKRTKFF 788

  Fly   929 KAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEK-ELGLPF 992
            |.......|.:....::.:.|:::...||....|.|.|..|...|:..||:.|||.|| ||.:..
Zfish   789 KLAENNSCLWKDEGHRELLRSMLMTASDICAITKPWPVQKRIAELVATEFYAQGDREKRELNIQP 853

  Fly   993 SPLCDRNN-TLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNK 1038
            ..:.||.| :.:.:.|:.:||.|..|    :.:.|..|....:|:.:
Zfish   854 IDVMDRENASRLPQMQVDYIDGICSP----LYEALAFICESCSPLKE 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	662..722	CDD:462497
		PDEase_I	807..1027	CDD:459723	65/225 (29%)
pde5aa	XP_009305135.1	GAF	245..388	CDD:214500
		GAF	<390..>634	CDD:441805	10/37 (27%)
		PDEase_I	664..898	CDD:459723	68/238 (29%)