DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde1c and pde5aa

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_009305135.1	Gene:	pde5aa / 100334568	ZFINID:	ZDB-GENE-100414-2	Length:	922	Species:	Danio rerio

Alignment Length:	307	Identity:	85/307 - (27%)
Similarity:	140/307 - (45%)	Gaps:	20/307 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   738 DVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCR 802
            |.:.||    |:.|..|.:::.|..|.|    ..:|.......:|||....|..::..|::.| |
Zfish   604 DTLSLL----DFGFSDFDMSQNAMTQAV----VRMFLDLNLPQEFKIDYKALCQWVLSVQKCY-R 659

  Fly   803 YRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSET 867
            ....|||..||:...|.:...|....|.:.|:.||:.|.::|:|.||.:|.|..|::...|....
Zfish   660 SNVVYHNWSHALRTAQCMFAMLQTKELKSNLSSLEVLALMIASLSHDLDHRGVNNSYIQRSNQPL 724

  Fly   868 ALLYNDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQ----M 928
            |.||. ::.||:||......:|......|||.||..|:.....::.:.:|.||:...|::    .
Zfish   725 AQLYG-QSSLEHHHYDMCLLILNNPGSQILSSLSVNEYMACLQMIEKNILATDLAIFFEKRTKFF 788

  Fly   929 KAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEK-ELGLPF 992
            |.......|.:....::.:.|:::...||....|.|.|..|...|:..||:.|||.|| ||.:..
Zfish   789 KLAENNSCLWKDEGHRELLRSMLMTASDICAITKPWPVQKRIAELVATEFYAQGDREKRELNIQP 853

  Fly   993 SPLCDRNN-TLVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNK 1038
            ..:.||.| :.:.:.|:.:||.|..|    :.:.|..|....:|:.:
Zfish   854 IDVMDRENASRLPQMQVDYIDGICSP----LYEALAFICESCSPLKE 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	65/224 (29%)
pde5aa	XP_009305135.1	GAF	245..388	CDD:214500
		GAF	415..558	CDD:307634
		PDEase_I	664..894	CDD:306695	67/234 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920