DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde1c and pde2a

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_021322214.1	Gene:	pde2a / 100332468	-ID:	-	Length:	851	Species:	Danio rerio

Alignment Length:	540	Identity:	132/540 - (24%)
Similarity:	229/540 - (42%)	Gaps:	121/540 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   621 AAESQAGSAGSSGSCSN--PAAVHRQRRLRTPTWARSMSTN---KTR------LADEDDE---LS 671
            |.:..||...::|...|  .|..|       |.:.|.:..:   :||      :.||::|   ::
Zfish   365 ADQGIAGHVATTGKILNIKDAYSH-------PLFYRGVDDSTGFRTRNILCFPIKDENEEVIGVA 422

  Fly   672 EVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFR-----SVAHAIRAGIFVDRMYRRVS--- 728
            |: .....|    |. :.|...:||:         |.     |:||::        :|:||.
Zfish   423 ELXNKTNGP----WF-NRFDEDLATA---------FSIYCGISIAHSL--------LYKRVHEAQ 465

  Fly   729 ---------------------SSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYEL 772
                                 |..||.....|.::..|..::|:...:|.:..:...|    ..:
Zfish   466 FRSHLANEMMMYHMKVSEEEVSKLLTIGIESVQKIHANFAEFTYTPRSLPDDNTPMAV----LSM 526

  Fly   773 FNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRN-PYHNNLHAVDVMQTIHYCLC---NTGLMNWL 833
            |...|.|:.:||....|..|...|::|   ||: ||||.:||..|.   |:|..   |..|.|:|
Zfish   527 FEDMGFINTYKIDLHTLARFCLMVKKG---YRDPPYHNWMHAFSVS---HFCYLLYKNLELSNYL 585

  Fly   834 TDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLY-NDRAVLENHHASASFRLLREDEYNIL 897
            .|:||.|..::.:.||.:|.||.|:|.|.|.|..|.|| ::.:|:|.||.:.:..:|.....||.
Zfish   586 QDIEILALFVSCMCHDLDHRGTNNSFQVASQSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIF 650

  Fly   898 SHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTL---QEATIDKQKVLSLVLHCCDISH 959
            ...||::::.:..|:.:::|.||:.:|.:..|.::::..:   ......:..:|.|::..||:|.
Zfish   651 EKFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMADVGFNPNNRTHRSLLLCLLMTSCDLSD 715

  Fly   960 PAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMGVM-- 1022
            ..|.|....:...|:.:|||.||||||.:|...|.:.||....:.|.||.|::.|..|...::
Zfish   716 QTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPSEMMDREKAYIPELQISFMEHIAMPIYKLLQE 780

  Fly  1023 -----SDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTEAKT 1082
                 :::.|.:.|     |:.:.|. |.|:.|...       :|::.....:|:
Zfish   781 IFPRSAELYERVSA-----NREQWAK-VSHKFTIRG-------LPSNNSLDFLDE---------- 822

  Fly  1083 TAAECLARKSVTGTTASKFN 1102
             ..|.|..:...|....:||
Zfish   823 -EFEMLQSQGAFGDEPQRFN 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	12/63 (19%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	71/232 (31%)
pde2a	XP_021322214.1	GAF	138..289	CDD:214500
		GAF	311..462	CDD:214500	26/125 (21%)
		PDEase_I	559..789	CDD:306695	71/232 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920