DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde1c and pde1b

DIOPT Version :9

Sequence 1:	NP_001137817.1	Gene:	Pde1c / 34594	FlyBaseID:	FBgn0264815	Length:	1173	Species:	Drosophila melanogaster
Sequence 2:	XP_017946519.1	Gene:	pde1b / 100036722	XenbaseID:	XB-GENE-987197	Length:	554	Species:	Xenopus tropicalis

Alignment Length:	613	Identity:	259/613 - (42%)
Similarity:	353/613 - (57%)	Gaps:	92/613 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   565 PAPKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAK--------- 620
            |.| |.|.        |.||||.|            ..|....|:.....:.||.|
Frog    14 PLP-LHPG--------MMESPSVD------------KDLLEGCTSPFELKSAPSKKMWVKLRSLL 57

  Fly   621 ---AAESQAGSAGSSGSCSNPAAVHRQRRLR-TPTWARSMSTNKTR-LADEDDELSEVQPDAVPP 680
               ..:.:.|...         .|..::.|. |.:...::..::|| :.|.||||.|::.|:||.
Frog    58 KYMVKQLENGEVN---------IVELKKNLEYTASLLEAVYIDETRQILDTDDELPEMRSDSVPS 113

  Fly   681 EVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDRMYRRVSSSALTAFPPD----VVR 741
            |||:|||||||:|..::.|:|:|||:|||:.||::|||||:||:||    :.||..|:    ||.
Frog   114 EVRDWLASTFTQQTRSTGRRSEEKPRFRSIVHAVQAGIFVERMFRR----SYTAVGPNYSAAVVN 174

  Fly   742 LLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEAFLHRVEEGYCRYRNP 806
            .||:||.|.||||.|...:....:|.:.:||.:|:....:|||....|.:||..:|.||.:|:||
Frog   175 SLKHLDLWDFDVFVLNRVSEDHALKTIVFELLSRHNLNSRFKIPVAFLMSFLDSLESGYGKYKNP 239

  Fly   807 YHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLY 871
            |||.:||.||.||:|..|..||:::.|.::||.|.:.||.:||:|||||||:||:.:.|:.|:||
Frog   240 YHNQIHAADVTQTVHCFLLRTGMVHCLNEIEILAIIFAAAIHDFEHTGTTNSFHIQTKSDCAILY 304

  Fly   872 NDRAVLENHHASASFRLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLT 936
            |||:||||||.||.:|::::||.||..:|:::||.|||.|||||||.|||:.||||:|.|:..|.
Frog   305 NDRSVLENHHVSAVYRIMQDDEMNIFVNLTKDEFTELRSLVIEMVLATDMSCHFQQVKTMKTSLQ 369

  Fly   937 LQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNT 1001
             |..||||.|.|||:||..|||||.|||.||.|||..|:||||||||.|.|:||||||||||.:|
Frog   370 -QLETIDKSKALSLLLHAADISHPTKQWKVHARWTKALMEEFFRQGDKEAEMGLPFSPLCDRKST 433

  Fly  1002 LVAESQICFIDFIVEPSMGVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSG- 1065
            |||:|||.||:|||:|:..|::|:.|..:.|           |||..:.:.||   |.|..:|.
Frog   434 LVAQSQIGFIEFIVDPTFSVLTDVAEKTVLP-----------LVEERSKSKST---ASVNQSSSQ 484

  Fly  1066 -ITPSMDKPRDHRTEAKTTAAECLARKSVTGTTASKFNIPKPWLTCLVENKRIWKEQAVKDAEAR 1129
             ..||:|   || :|.....|:.   ||...|          |...:.|||:.|||:|   |...
Frog   485 WRQPSID---DH-SEMGDINADI---KSFRTT----------WTKYIQENKQKWKERA---ASGI 529

  Fly  1130 ALATAAEEAAAAAAAEAEESKPETETAD 1157
            ...|:.:|   .:..|.:.|..|....|
Frog   530 TNQTSVDE---LSPCEEQHSTEENGNLD 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde1c	NP_001137817.1	PDEase_I_N	666..722	CDD:285672	34/55 (62%)
Pde1c	NP_001137817.1	PDEase_I	807..1026	CDD:278654	133/218 (61%)
pde1b	XP_017946519.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	307	1.000	Domainoid score	I1342
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1093
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439875at33208
OrthoFinder	1	1.000	-	-		FOG0001902
OrthoInspector	1	1.000	-	-		otm48292
Panther	1	1.100	-	-	O	PTHR11347
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X171
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160