DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF765

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001035275.1	Gene:	ZNF765 / 91661	HGNCID:	25092	Length:	523	Species:	Homo sapiens

Alignment Length:	438	Identity:	160/438 - (36%)
Similarity:	229/438 - (52%)	Gaps:	49/438 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 SLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKH 355
            |.||:.:.::.:||.           |..|...|.||..|        ...|..:|.:.|.|.|.
Human   122 STERYDQNYAGNKPV-----------KYQLGFSFHSHLPE--------LHIFHTEEKIDNQVVKS 167

  Fly   356 TGE-----TPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNET 415
            ..:     |..|.. |:........|.|:::            ....:|:|:.:  |||    |.
Human   168 IHDASLVSTAQRIS-CRPETHISNDYGNNFL------------NSSLFTQKQEV--HMR----EK 213

  Fly   416 PFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMK 480
            .|:|...||:::.......|.|.|.||..::||.|.|.|..|.::..|.|.||||.|::|:.|.|
Human   214 SFQCNDSGKAYNCSSLLRKHQLIHLGEKQYKCDICGKVFNSKRYVARHRRCHTGEKPYKCNECGK 278

  Fly   481 TFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLT 545
            ||::..:|..|.|.||||.|:||..|.|||..|..:..|.|.||||.|:||..|.|||::|.:||
Human   279 TFSQTYYLTCHRRLHTGEKPYKCEECDKAFHFKSKLQIHRRIHTGEKPYKCNECGKTFSQKSYLT 343

  Fly   546 NHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSD 610
            .|.|.|||:.|::|:.|.|||:||.|.|.|.|:|||:.|:||..|.|||:.|..|..|.|.|:.:
Human   344 CHRRLHTGEKPYKCNECGKTFSRKSHFTCHHRVHTGEKPYKCNECSKTFSHKSSLTYHRRLHTEE 408

  Fly   611 NPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFA 675
            .|:.||.|.|.|  .:.|..::.|.|:|::|:.||.|.|::..|.||..||:.||:    |.|:.
Human   409 KPYKCNECGKTF--NQQLTLNICRLHSGEKPYKCEECDKAYSFKSNLEIHQKIHTE----ENPYK 467

  Fly   676 CEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKM 723
            |.:|.|.|.....|..|.|.|:|:||:.|..|.:||..:.||:||.::
Human   468 CNECGKTFSRTSSLTYHHRLHTGQKPYKCEDCDEAFSFKSNLERHRRI 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368	3/7 (43%)
		COG5048	300..723	CDD:227381	157/427 (37%)
		C2H2 Zn finger	307..327	CDD:275368	3/19 (16%)
		C2H2 Zn finger	335..355	CDD:275368	4/19 (21%)
		C2H2 Zn finger	363..383	CDD:275368	3/19 (16%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	10/19 (53%)
		C2H2 Zn finger	559..579	CDD:275368	11/19 (58%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
ZNF765	NP_001035275.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	217..237	CDD:275368	5/19 (26%)
		zf-H2C2_2	230..254	CDD:290200	10/23 (43%)
		C2H2 Zn finger	245..265	CDD:275368	8/19 (42%)
		zf-H2C2_2	260..282	CDD:290200	12/21 (57%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	285..309	CDD:290200	13/23 (57%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		zf-H2C2_2	314..338	CDD:290200	13/23 (57%)
		COG5048	<325..477	CDD:227381	70/157 (45%)
		C2H2 Zn finger	329..349	CDD:275368	10/19 (53%)
		zf-H2C2_2	341..366	CDD:290200	13/24 (54%)
		C2H2 Zn finger	357..377	CDD:275368	11/19 (58%)
		C2H2 Zn finger	385..405	CDD:275368	9/19 (47%)
		zf-H2C2_2	397..422	CDD:290200	10/26 (38%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)
		zf-H2C2_2	452..477	CDD:290200	12/28 (43%)
		C2H2 Zn finger	468..488	CDD:275368	7/19 (37%)
		C2H2 Zn finger	496..515	CDD:275368	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900