DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF682

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_016882944.1	Gene:	ZNF682 / 91120	HGNCID:	28857	Length:	504	Species:	Homo sapiens

Alignment Length:	441	Identity:	155/441 - (35%)
Similarity:	207/441 - (46%)	Gaps:	34/441 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 PIATGTHVCD--ICGKMFQFRYQLIVHRRYHSERKPFMCQVCG-QGFTTSQDLTRHG------KI 270
            |.|..:|..:  :..:..|..:|.::.|||.|         || :.....:|....|      :|
Human    80 PPAMSSHYTEDLLPEQCMQDSFQKVILRRYGS---------CGLEDLHLRKDGENVGECKDQKEI 135

  Fly   271 HIG---------GPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRS 326
            :.|         ..:|....|..||:.:::|.|...||:|:|.|.|..|.|.|.....|..|...
Human   136 YNGLNQCLSTLPSKIFPYNKCVKVFSKSSNLNRENIRHTTEKLFKCMQCGKVFKSHSGLSYHKII 200

  Fly   327 HTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQC 391
            ||.|....|:.|.|||....::..|.|.||||.|::|:.|.|:|........|...|||:.|::|
Human   201 HTEEKLCICEECGKTFKWFSYLTKHKRIHTGEKPYKCEECGKAFNWCSSLTKHKRIHTGEKPYKC 265

  Fly   392 DVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTR 456
            :.|||.:........|.:.||.|.|:.||.||::|:|..|.|.|...|||:.|::|..|.|.|..
Human   266 EECGKAFHWCSPFVRHKKIHTGEKPYTCEDCGRAFNRHSHLTKHKTIHTGKKPYKCKECGKAFNH 330

  Fly   457 KEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVR 521
            ...|..|.|.||||.|::|..|.|.|.....|..|...|:||.|:||..|.|.|.|..::..|.|
Human   331 CSLLTIHERTHTGEKPYKCEECGKAFNSSSILTEHKVIHSGEKPYKCEKCDKVFKRFSYLTKHKR 395

  Fly   522 QHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHK 586
            .||||.|:||..|.|.|.....||.|.|.|||:.|:.|..|.|.|.|..|||.|.::||....:|
Human   396 IHTGEKPYKCEECGKAFNWSSILTEHKRIHTGEKPYNCEECGKAFNRCSHLTRHKKIHTAVKRYK 460

  Fly   587 CEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHT 637
            ||.|.|.|.|..|||.|.|....:.......|.:.|       ||.|...|
Human   461 CEECGKAFKRCSHLNEHKRVQRGEKSCKYKKCGEAF-------NHCSNLTT 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/21 (19%)
		C2H2 Zn finger	251..271	CDD:275368	4/26 (15%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	132/338 (39%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	11/19 (58%)
		C2H2 Zn finger	615..636	CDD:275368	5/20 (25%)
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF682	XP_016882944.1	KRAB	10..70	CDD:214630
		KRAB	10..49	CDD:279668
		C2H2 Zn finger	153..173	CDD:275368	5/19 (26%)
		C2H2 Zn finger	181..201	CDD:275368	6/19 (32%)
		C2H2 Zn finger	209..229	CDD:275368	7/19 (37%)
		zf-H2C2_2	221..245	CDD:290200	10/23 (43%)
		C2H2 Zn finger	237..257	CDD:275368	5/19 (26%)
		COG5048	<245..451	CDD:227381	84/205 (41%)
		zf-H2C2_2	249..273	CDD:290200	9/23 (39%)
		C2H2 Zn finger	265..285	CDD:275368	5/19 (26%)
		zf-H2C2_2	280..302	CDD:290200	10/21 (48%)
		C2H2 Zn finger	293..313	CDD:275368	9/19 (47%)
		zf-H2C2_2	305..330	CDD:290200	11/24 (46%)
		C2H2 Zn finger	321..341	CDD:275368	7/19 (37%)
		zf-H2C2_2	334..358	CDD:290200	12/23 (52%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		zf-H2C2_2	362..386	CDD:290200	11/23 (48%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		zf-H2C2_2	389..413	CDD:290200	11/23 (48%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		zf-H2C2_2	418..442	CDD:290200	12/23 (52%)
		C2H2 Zn finger	433..453	CDD:275368	9/19 (47%)
		zf-H2C2_2	445..470	CDD:290200	12/24 (50%)
		C2H2 Zn finger	461..480	CDD:275368	10/18 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900