DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF251

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_612376.1	Gene:	ZNF251 / 90987	HGNCID:	13045	Length:	671	Species:	Homo sapiens

Alignment Length:	458	Identity:	170/458 - (37%)
Similarity:	233/458 - (50%)	Gaps:	28/458 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 NVFANNTSLERH---MKRHST-DKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTR 344
            :.|..|.:|:::   ::|:.| ::.|.|.||.|||.....|..|.||||||.|:.|..|.:.||.
Human   184 SAFDRNLNLDQNVVRLQRNKTGERVFKCDICSKTFKYNSDLSRHQRSHTGEKPYECGRCGRAFTH 248

  Fly   345 KEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMR 409
            ..::|.|...|||..|.:||.|.|:|....|...|...|||:.|..|..|||.::|...|..|..
Human   249 SSNLVLHHHIHTGNKPFKCDECGKTFGLNSHLRLHRRIHTGEKPFGCGECGKAFSRSSTLIQHRI 313

  Fly   410 SHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHR 474
            .||.|.|::|..||:.||:....|.|...||||.||.|..|.|.|:|...|:.|.|.||||.||:
Human   314 IHTGEKPYKCNECGRGFSQSPQLTQHQRIHTGEKPHECSHCGKAFSRSSSLIQHERIHTGEKPHK 378

  Fly   475 CSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFT 539
            |:.|.|.|::...|..|.|.||||.|:.|..|.:||....|:..|||.||||.|:.|..|.|.|.
Human   379 CNQCGKAFSQSSSLFLHHRVHTGEKPYVCNECGRAFGFNSHLTEHVRIHTGEKPYVCNECGKAFR 443

  Fly   540 RKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHM 604
            |...|..|.|.|||:.|::|..|.|.|::...||.|.|:|||:.|:.|..|.|.|:|:..|..|.
Human   444 RSSTLVQHRRVHTGEKPYQCVECGKAFSQSSQLTLHQRVHTGEKPYDCGDCGKAFSRRSTLIQHQ 508

  Fly   605 RQHSSDNPHC------------CNVCNKPFTRKEH--LINHMSR------CHTGDRPFTCETCGK 649
            :.||.:...|            .....:..|.::|  ..||.:.      .|||::.|.|...||
Human   509 KVHSGETRKCRKHGPAFVHGSSLTADGQIPTGEKHGRAFNHGANLILRWTVHTGEKSFGCNEYGK 573

  Fly   650 SFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVER 714
            :|.........|..|..    |:|:.|::|...|..|..|:.|..:|:|:||..|::..|||.:.
Human   574 AFSPTSRPTEDQIMHAG----EKPYKCQECGNAFSGKSTLIQHQVTHTGQKPCHCSVYGKAFSQS 634

  Fly   715 GNL 717
            ..|
Human   635 SQL 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368	3/17 (18%)
		COG5048	300..723	CDD:227381	166/439 (38%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	4/28 (14%)
		C2H2 Zn finger	644..664	CDD:275368	5/19 (26%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	5/14 (36%)
ZNF251	NP_612376.1	KRAB	15..75	CDD:214630
		C2H2 Zn finger	181..203	CDD:275368	4/18 (22%)
		COG5048	207..635	CDD:227381	164/431 (38%)
		C2H2 Zn finger	211..231	CDD:275368	9/19 (47%)
		C2H2 Zn finger	239..259	CDD:275368	6/19 (32%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	407..427	CDD:275368	8/19 (42%)
		C2H2 Zn finger	435..455	CDD:275368	8/19 (42%)
		C2H2 Zn finger	463..483	CDD:275368	8/19 (42%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	568..588	CDD:275368	5/19 (26%)
		C2H2 Zn finger	596..616	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960