DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF439

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001335647.1	Gene:	ZNF439 / 90594	HGNCID:	20873	Length:	507	Species:	Homo sapiens

Alignment Length:	466	Identity:	141/466 - (30%)
Similarity:	210/466 - (45%)	Gaps:	35/466 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 VCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQ---YCAKTF 342
            |....|.|.||:.:..|..:.:..:            ::...:|||.|.|.....:   :|.:||
Human    55 VMLETFWNLTSIGKKWKDQNIEYEY------------QNPRRNFRSVTEEKVNEIKEDSHCGETF 107

  Fly   343 TR-KEHMVNHVRKHTGETPHRCD--ICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEH- 403
            |. .:..:|..:|........||  :|:.........:| ....||....:|...|.|..:.:.
Human   108 TPVPDDRLNFQKKKASPEVKSCDSFVCEVGLGNSSSNMN-IRGDTGHKACECQEYGPKPWKSQQP 171

  Fly   404 ---------LANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEH 459
                     |....|.||.:.|:.|:.|||:.........|::.|:|:.|::|.||.|.|.....
Human   172 KKAFRYHPSLRTQERDHTGKKPYACKECGKNIIYHSSIQRHMVVHSGDGPYKCKFCGKAFHCLSL 236

  Fly   460 LLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHT 524
            .|.|.|.||||.|:.|..|.|:|:.......|.|.|.||.|::|..|.|||........|.|.|.
Human   237 YLIHERTHTGEKPYECKQCGKSFSYSATHRIHERTHIGEKPYECQECGKAFHSPRSCHRHERSHM 301

  Fly   525 GESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEY 589
            ||..::|..|.|.|....::..|.|.|:....:.|..|.|..:.......|:|:|:|:.|::|:.
Human   302 GEKAYQCKECGKAFMCPRYVRRHERTHSRKKLYECKQCGKALSSLTSFQTHIRMHSGERPYECKT 366

  Fly   590 CQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLK 654
            |.|.|...:....|.:.||.:.|:.|..|.|.|||......| .|.|||::|:.|:.|||:|...
Human   367 CGKGFYSAKSFQRHEKTHSGEKPYKCKQCGKAFTRSGSFRYH-ERTHTGEKPYECKQCGKAFRSA 430

  Fly   655 GNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKR 719
            .||..|.|:||.    |:|:.|::|.|.|.....|..|.|.|:||||:.|..|.|||....|.:.
Human   431 PNLQLHGRTHTG----EKPYQCKECGKAFRSASQLRIHRRIHTGEKPYECKKCGKAFRYVQNFRF 491

  Fly   720 HMK-MNHPDAM 729
            |.: ..|.:|:
Human   492 HERTQTHKNAL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368	6/17 (35%)
		COG5048	300..723	CDD:227381	133/439 (30%)
		C2H2 Zn finger	307..327	CDD:275368	2/19 (11%)
		C2H2 Zn finger	335..355	CDD:275368	5/23 (22%)
		C2H2 Zn finger	363..383	CDD:275368	4/21 (19%)
		C2H2 Zn finger	391..411	CDD:275368	5/29 (17%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	5/19 (26%)
		C2H2 Zn finger	587..607	CDD:275368	5/19 (26%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF439	NP_001335647.1	KRAB	26..67	CDD:307490	5/11 (45%)
		C2H2 Zn finger	196..216	CDD:275368	5/19 (26%)
		COG5048	<204..381	CDD:227381	56/176 (32%)
		C2H2 Zn finger	224..244	CDD:275368	8/19 (42%)
		C2H2 Zn finger	252..272	CDD:275368	6/19 (32%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		C2H2 Zn finger	308..328	CDD:275368	6/19 (32%)
		COG5048	<321..492	CDD:227381	62/175 (35%)
		C2H2 Zn finger	336..356	CDD:275368	5/19 (26%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		C2H2 Zn finger	392..412	CDD:275368	8/20 (40%)
		C2H2 Zn finger	420..440	CDD:275368	9/19 (47%)
		C2H2 Zn finger	448..468	CDD:275368	7/19 (37%)
		C2H2 Zn finger	476..495	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900