DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF700

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001258777.1	Gene:	ZNF700 / 90592	HGNCID:	25292	Length:	745	Species:	Homo sapiens

Alignment Length:	510	Identity:	184/510 - (36%)
Similarity:	256/510 - (50%)	Gaps:	11/510 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 GTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCF 283
            ||:.|..|||.|......::|.|.|:..||:.|:.||:.||.|..|..|.:.|.|...:.|..|.
Human   223 GTYKCKFCGKAFHSFSLYLIHERTHTGEKPYECKQCGKSFTYSATLQIHERTHTGEKPYECSKCD 287

  Fly   284 NVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHM 348
            ..|.:::|..||.:.|..:||:.|..|.|.||....|..|.|:|:|:.|:.|:...:..:.....
Human   288 KAFHSSSSYHRHERSHMGEKPYQCKECGKAFAYTSSLRRHERTHSGKKPYECKQYGEGLSYLISF 352

  Fly   349 VNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTN 413
            ..|:|.::||.|::|.||.|.|...:.:..|...|||:..::|..|||.:........|.|.||.
Human   353 QTHIRMNSGERPYKCKICGKGFYSAKSFQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHERIHTG 417

  Fly   414 ETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYC 478
            |.|:.|:.|||:|........|...||||.|:.|..|.|.|....||..|.|.||||.|:.|..|
Human   418 EKPYECKQCGKAFRSASQLRVHGGTHTGEKPYECKECGKAFRSTSHLRVHGRTHTGEKPYECKEC 482

  Fly   479 MKTFTRKEHL------VNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKT 537
            .|.|...:||      ..|||..:||.|:||:.|.|.|........|.:.||||.|::|..|.|.
Human   483 GKAFRYVKHLQIHERTEKHIRMPSGERPYKCSICEKGFYSAKSFQTHEKTHTGEKPYECNQCGKA 547

  Fly   538 FTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNN 602
            |.....|..|.|.|||:.|:.|..|.|.|....||..|.|.|||:.|::|:.|.|.|:...:|..
Human   548 FRCCNSLRYHERTHTGEKPYECKQCGKAFRSASHLRMHERTHTGEKPYECKQCGKAFSCASNLRK 612

  Fly   603 HMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKG 667
            |.|.|:.:.|:.|..|.|.|....:|..| .|.|||::|:.|:.|.|:|....:...|:|.| :|
Human   613 HGRTHTGEKPYECKQCGKAFRSASNLQMH-ERTHTGEKPYECKECEKAFCKFSSFQIHERKH-RG 675

  Fly   668 QEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMK 722
               |:|:.|:.|...|.....|..|.|:|.|||.:.|..|.|||....:|..|.:
Human   676 ---EKPYECKHCGNGFTSAKILQIHARTHIGEKHYECKECGKAFNYFSSLHIHAR 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	155/429 (36%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	3/19 (16%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	9/25 (36%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	6/19 (32%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF700	NP_001258777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		KRAB	27..>69	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	169..191	CDD:275368
		C2H2 Zn finger	199..219	CDD:275368
		COG5048	224..636	CDD:227381	149/411 (36%)
		C2H2 Zn finger	227..247	CDD:275368	7/19 (37%)
		zf-H2C2_2	243..264	CDD:290200	9/20 (45%)
		C2H2 Zn finger	255..275	CDD:275368	8/19 (42%)
		zf-H2C2_2	268..292	CDD:290200	7/23 (30%)
		C2H2 Zn finger	283..303	CDD:275368	6/19 (32%)
		zf-H2C2_2	298..320	CDD:290200	9/21 (43%)
		C2H2 Zn finger	311..331	CDD:275368	8/19 (42%)
		C2H2 Zn finger	367..387	CDD:275368	6/19 (32%)
		zf-H2C2_2	379..403	CDD:290200	8/23 (35%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		zf-H2C2_2	407..432	CDD:290200	11/24 (46%)
		C2H2 Zn finger	423..443	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		zf-H2C2_2	463..488	CDD:290200	13/24 (54%)
		C2H2 Zn finger	479..498	CDD:275368	6/18 (33%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
		zf-H2C2_2	525..550	CDD:290200	10/24 (42%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	553..578	CDD:290200	11/24 (46%)
		C2H2 Zn finger	569..589	CDD:275368	8/19 (42%)
		zf-H2C2_2	581..606	CDD:290200	12/24 (50%)
		C2H2 Zn finger	597..617	CDD:275368	7/19 (37%)
		zf-H2C2_2	609..634	CDD:290200	9/24 (38%)
		C2H2 Zn finger	625..645	CDD:275368	7/20 (35%)
		zf-H2C2_2	637..660	CDD:290200	10/23 (43%)
		C2H2 Zn finger	653..673	CDD:275368	6/19 (32%)
		C2H2 Zn finger	681..701	CDD:275368	6/19 (32%)
		C2H2 Zn finger	709..729	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860