DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF587

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_116217.1	Gene:	ZNF587 / 84914	HGNCID:	30955	Length:	575	Species:	Homo sapiens

Alignment Length:	493	Identity:	182/493 - (36%)
Similarity:	257/493 - (52%)	Gaps:	31/493 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 HVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNV 285
            |.|::||.:.:..:....|:..|.::|......||:....:..|.:|.|.|||...:...|
Human    92 HPCEMCGLILEDVFHFADHQETHHKQKLNRSGACGKNLDDTAYLHQHQKQHIGEKFYRKSV---- 152

  Fly   286 FANNTSLERHMKRHSTDKPF-----------ACTICQKTFARKEHLDNH------FRSHTGETPF 333
              ...|..:..|...:.:||           :..:||:. |..|..|:.      |:.  |:|.:
Human   153 --REASFVKKRKLRVSQEPFVFREFGKDVLPSSGLCQEE-AAVEKTDSETMHGPPFQE--GKTNY 212

  Fly   334 RCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKY 398
            .|....|.|:.|..::.|.:..|.:..:.|..|.|||:|...:.||...||.:.|:.|..|||.|
Human   213 SCGKRTKAFSTKHSVIPHQKLFTRDGCYVCSDCGKSFSRYVSFSNHQRDHTAKGPYDCGECGKSY 277

  Fly   399 TRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNH 463
            :||..|..|.|.||.:|.:.||.||||||:|....:|.|.||||.|:.|..|.|:|.:|.:|:.|
Human   278 SRKSSLIQHQRVHTGQTAYPCEECGKSFSQKGSLISHQLVHTGEGPYECRECGKSFGQKGNLIQH 342

  Fly   464 VRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESP 528
            .:.||||..:.|..|.|:|.:|...:||.|.||||.|:||..|.|:|.:|.::|:|.|.||||.|
Human   343 QQGHTGERAYHCGECGKSFRQKFCFINHQRVHTGERPYKCGECGKSFGQKGNLVHHQRGHTGERP 407

  Fly   529 HKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKT 593
            ::|..|.|:|..:.|||.|.|.|||:.|:.|..|.|.|.||.||..|.|:|||:.|:.||.|.|.
Human   408 YECKECGKSFRYRSHLTEHQRLHTGERPYNCRECGKLFNRKYHLLVHERVHTGERPYACEVCGKL 472

  Fly   594 FTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLL 658
            |..|..:..|.|.|:.:.|:.|:.|.|.|.....|..| .|.|:|.:|:.|..|||||....:|:
Human   473 FGNKHSVTIHQRIHTGERPYECSECGKSFLSSSALHVH-KRVHSGQKPYKCSECGKSFSECSSLI 536

  Fly   659 FHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSH 696
            .|:|.||.    |||:.|.||.|.|.....|:.|..||
Human   537 KHRRIHTG----ERPYECTKCGKTFQRSSTLLHHQSSH 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	164/414 (40%)
		C2H2 Zn finger	307..327	CDD:275368	6/25 (24%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		C2H2 Zn finger	391..411	CDD:275368	10/19 (53%)
		C2H2 Zn finger	419..439	CDD:275368	11/19 (58%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	10/19 (53%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF587	NP_116217.1	KRAB	15..70	CDD:214630
		KRAB	15..54	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..88
		C2H2 Zn finger	94..114	CDD:275368	4/19 (21%)
		C2H2 Zn finger	122..142	CDD:275368	5/19 (26%)
		C2H2 Zn finger	242..262	CDD:275368	8/19 (42%)
		C2H2 Zn finger	270..290	CDD:275368	10/19 (53%)
		COG5048	<273..568	CDD:227381	134/299 (45%)
		C2H2 Zn finger	298..318	CDD:275368	11/19 (58%)
		C2H2 Zn finger	326..343	CDD:275368	6/16 (38%)
		C2H2 Zn finger	354..374	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..389	CDD:290200	12/19 (63%)
		C2H2 Zn finger	382..402	CDD:275368	8/19 (42%)
		zf-H2C2_2	394..419	CDD:290200	12/24 (50%)
		C2H2 Zn finger	410..430	CDD:275368	9/19 (47%)
		zf-H2C2_2	422..447	CDD:290200	13/24 (54%)
		C2H2 Zn finger	438..458	CDD:275368	10/19 (53%)
		zf-H2C2_2	450..473	CDD:290200	12/22 (55%)
		C2H2 Zn finger	466..486	CDD:275368	8/19 (42%)
		zf-H2C2_2	478..503	CDD:290200	8/24 (33%)
		C2H2 Zn finger	494..514	CDD:275368	7/20 (35%)
		zf-H2C2_2	509..530	CDD:290200	10/21 (48%)
		C2H2 Zn finger	522..542	CDD:275368	9/19 (47%)
		zf-H2C2_2	534..557	CDD:290200	12/26 (46%)
		C2H2 Zn finger	550..570	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810