DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF496

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_116141.1	Gene:	ZNF496 / 84838	HGNCID:	23713	Length:	587	Species:	Homo sapiens

Alignment Length:	183	Identity:	61/183 - (33%)
Similarity:	84/183 - (45%)	Gaps:	18/183 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 TGETPFKCTYCTKAFTRKDHMVNHVR-QHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRC 559
            |.:..:.|..|.|.|..:.:.:.|:| :...|.||:|:.|.:.|:..|.|..|:..|....|:||
Human   401 TSKKSYVCPNCGKIFRWRVNFIRHLRSRREQEKPHECSVCGELFSDSEDLDGHLESHEAQKPYRC 465

  Fly   560 SYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTR---------KEHLNNHMRQHSSDNPHCC 615
            ..|.|:|....||.:|.|:|.  .|.:.:..:|....         ||.|.|...:.|.   .||
Human   466 GACGKSFRLNSHLLSHRRIHL--QPDRLQPVEKREQAASEDADKGPKEPLENGKAKLSF---QCC 525

  Fly   616 NVCNKPFTRKEHLINHMSRCHTGD--RPFTCETCGKSFPLKGNLLFHQRSHTK 666
            . |.|.|.|.:||..|.|..|..|  |||.|..|.|||....:||.|:|.|.|
Human   526 E-CGKAFQRHDHLARHRSHFHLKDKARPFQCRYCVKSFTQNYDLLRHERLHMK 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		COG5048	300..723	CDD:227381	61/183 (33%)
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368
		C2H2 Zn finger	363..383	CDD:275368
		C2H2 Zn finger	391..411	CDD:275368
		C2H2 Zn finger	419..439	CDD:275368
		C2H2 Zn finger	447..467	CDD:275368
		C2H2 Zn finger	475..495	CDD:275368
		C2H2 Zn finger	503..523	CDD:275368	6/20 (30%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	5/28 (18%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF496	NP_116141.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		SCAN	50..126	CDD:280241
		KRAB_A-box	222..259	CDD:143639
		KRAB	223..275	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..282
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..399
		C2H2 Zn finger	408..428	CDD:275368	6/19 (32%)
		COG5048	<427..>586	CDD:227381	54/157 (34%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		zf-C2H2	463..485	CDD:278523	9/21 (43%)
		C2H2 Zn finger	465..485	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..513		4/24 (17%)
		zf-C2H2	522..543	CDD:278523	9/24 (38%)
		C2H2 Zn finger	524..543	CDD:275368	9/19 (47%)
		zf-C2H2	553..575	CDD:278523	10/21 (48%)
		C2H2 Zn finger	555..575	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100