DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF607

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_116078.4	Gene:	ZNF607 / 84775	HGNCID:	28192	Length:	696	Species:	Homo sapiens

Alignment Length:	502	Identity:	185/502 - (36%)
Similarity:	264/502 - (52%)	Gaps:	6/502 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            |:.|||:|.:...|..|.:.|.| ||:.|:.||:.|.||:.||.|.:.|.|...:.|..|...|:
Human   172 CEECGKVFSYPANLAQHGKVHVE-KPYECKECGEAFRTSRQLTVHHRFHYGEKPYECKECGKAFS 235

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            ....|.||...|:.:|||.|..|.|:|..|..|..|...||||.|..|:.|.|.|.:..|:|.|.
Human   236 VYGRLSRHQSIHTGEKPFECNKCGKSFRLKAGLKVHQSIHTGEKPHECKECGKAFRQFSHLVGHK 300

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            |.||||.|:.|..|.|.||.:.....|...::|:..::|...|:.::....|.......:.|.|:
Human   301 RIHTGEKPYECKECGKGFTCRYQLTMHQRIYSGEKHYECKENGEAFSSGHQLTAPHTFESVEKPY 365

  Fly   418 RCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTF 482
            :||.|||:||.....|.|...|:|:.|:.|:.|.|:|.....|..|...||||.|::|..|.|.|
Human   366 KCEECGKAFSVHGRLTRHQGIHSGKKPYECNKCGKSFRLNSSLKIHQNIHTGEKPYKCKECGKAF 430

  Fly   483 TRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNH 547
            :::.||.:|.|.|||..||:|..|.|:|....::|.|.|.||||.|:.|..|.|.|:....||.|
Human   431 SQRAHLAHHNRIHTGYKPFECKECGKSFRCASYLVIHERIHTGEKPYVCQECGKGFSYSHKLTIH 495

  Fly   548 VRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNP 612
            .|.|||:.|:.|..|.|.|:....||.|:.:|:|..|.:|..|.|:|.....|..|...||::.|
Human   496 RRVHTGEKPYECKECGKAFSVSGQLTQHLSIHSGKKPFECNKCGKSFRFISVLKAHQNIHSAEKP 560

  Fly   613 HCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACE 677
            :.|..|.|.|.....||.| .|.|.|::.:.|:.||::|....:|:.|:|.||.    ::|:.|:
Human   561 YECKECGKAFRHATSLIYH-DRTHAGEKSYECKECGETFSHASHLIIHERIHTS----DKPYECK 620

  Fly   678 KCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            :|.|.|.|..:||.|...|:...|:.|..|.|||.....|..|.:::
Human   621 RCGKAFHCASYLVRHESVHADGNPYMCEECGKAFNSSHELSIHHRVH 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	251..271	CDD:275368	9/19 (47%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	156/422 (37%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	3/19 (16%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF607	NP_116078.4	KRAB	7..67	CDD:214630
		KRAB	7..45	CDD:279668
		C2H2 Zn finger	116..136	CDD:275368
		C2H2 Zn finger	144..164	CDD:275368
		C2H2 Zn finger	172..192	CDD:275368	7/19 (37%)
		C2H2 Zn finger	199..219	CDD:275368	9/19 (47%)
		C2H2 Zn finger	227..247	CDD:275368	6/19 (32%)
		zf-H2C2_2	240..262	CDD:290200	10/21 (48%)
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..292	CDD:290200	11/23 (48%)
		COG5048	279..687	CDD:227381	142/394 (36%)
		C2H2 Zn finger	283..303	CDD:275368	8/19 (42%)
		zf-H2C2_2	295..320	CDD:290200	13/24 (54%)
		C2H2 Zn finger	311..330	CDD:275368	6/18 (33%)
		C2H2 Zn finger	367..387	CDD:275368	9/19 (47%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		zf-H2C2_2	407..432	CDD:290200	11/24 (46%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		zf-H2C2_2	463..488	CDD:290200	12/24 (50%)
		C2H2 Zn finger	479..499	CDD:275368	8/19 (42%)
		zf-H2C2_2	492..515	CDD:290200	11/22 (50%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
		C2H2 Zn finger	535..555	CDD:275368	6/19 (32%)
		C2H2 Zn finger	563..583	CDD:275368	8/20 (40%)
		C2H2 Zn finger	591..611	CDD:275368	7/19 (37%)
		C2H2 Zn finger	619..639	CDD:275368	8/19 (42%)
		C2H2 Zn finger	647..667	CDD:275368	7/19 (37%)
		C2H2 Zn finger	675..695	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.950