DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF484

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_011517375.1	Gene:	ZNF484 / 83744	HGNCID:	23385	Length:	884	Species:	Homo sapiens

Alignment Length:	525	Identity:	214/525 - (40%)
Similarity:	285/525 - (54%)	Gaps:	26/525 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 HVCDICGKMFQFRYQLIVHRRYHS----------------ERKP-----FMCQVCGQGFTTSQDL 264
            |.|..|..:|..:.||...:|.::                ::.|     :.|...|:.|....||
Human   311 HECHECEAVFTQKSQLDGSQRVYAGICTEYEKDFSLKSNRQKTPYEGNYYKCSDYGRAFIQKSDL 375

  Fly   265 TRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTG 329
            .|..:||.|...:....|......|::|..|.|.|:..|.|.||.|.|.|.||..|..|.:.|||
Human   376 FRCQRIHSGEKPYEYSECEKNLPQNSNLNIHKKIHTGGKHFECTECGKAFTRKSTLSMHQKIHTG 440

  Fly   330 ETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVC 394
            |.|:.|..|.|.|.||.|.:.|.|.||||.|:.|..|.|||.:|.....|...|||:.|..|..|
Human   441 EKPYVCTECGKAFIRKSHFITHERIHTGEKPYECSDCGKSFIKKSQLHVHQRIHTGENPFICSEC 505

  Fly   395 GKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEH 459
            ||.:|.|.:|..|.:.||.|.|:.|.:|||:|:.:.:...|...||||.|::|..|.|:||.|..
Human   506 GKVFTHKTNLIIHQKIHTGERPYICTVCGKAFTDRSNLIKHQKIHTGEKPYKCSDCGKSFTWKSR 570

  Fly   460 LLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHT 524
            |..|.:.||||..:.||.|.|.|.:|..|..|.|.|.||.|:.||.|.|||..|.|.:.|.|.||
Human   571 LRIHQKCHTGERHYECSECGKAFIQKSTLSMHQRIHRGEKPYVCTECGKAFFHKSHFITHERIHT 635

  Fly   525 GESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEY 589
            ||.|::|:.|.|:||:|..|..|.:.|||:.|:||:.|.|.||.:.:|..|.::|||:.|:||..
Human   636 GEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAFTDRSNLFTHQKIHTGEKPYKCSD 700

  Fly   590 CQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLK 654
            |.|.||||..|:.|.:.|:.:..:.|:.|.|.|.||..||.| .|.|||::|:.|..|||||..|
Human   701 CGKAFTRKSGLHIHQQSHTGERHYECSECGKAFARKSTLIMH-QRIHTGEKPYICNECGKSFIQK 764

  Fly   655 GNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKR 719
            .:|..|:|.||.    |:|:.|..|.|:||.|..|..|.|.|:||||:.|..|.|||..|.||.:
Human   765 SHLNRHRRIHTG----EKPYECSDCGKSFIKKSQLHEHHRIHTGEKPYICAECGKAFTIRSNLIK 825

  Fly   720 HMKMN 724
            |.|::
Human   826 HQKIH 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	190/422 (45%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	10/19 (53%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	10/20 (50%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	9/19 (47%)
		C2H2 Zn finger	704..722	CDD:275368	9/17 (53%)
ZNF484	XP_011517375.1	KRAB	25..84	CDD:214630
		KRAB	25..64	CDD:279668
		C2H2 Zn finger	313..333	CDD:275368	6/19 (32%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..410	CDD:275368	5/18 (28%)
		zf-H2C2_2	402..427	CDD:290200	11/24 (46%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		zf-H2C2_2	431..455	CDD:290200	11/23 (48%)
		COG5048	442..843	CDD:227381	176/394 (45%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		zf-H2C2_2	458..481	CDD:290200	11/22 (50%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
		C2H2 Zn finger	502..522	CDD:275368	8/19 (42%)
		zf-H2C2_2	514..538	CDD:290200	10/23 (43%)
		C2H2 Zn finger	530..550	CDD:275368	6/19 (32%)
		zf-H2C2_2	542..566	CDD:290200	9/23 (39%)
		C2H2 Zn finger	558..578	CDD:275368	8/19 (42%)
		zf-H2C2_2	571..595	CDD:290200	11/23 (48%)
		C2H2 Zn finger	586..606	CDD:275368	9/19 (47%)
		zf-H2C2_2	599..621	CDD:290200	11/21 (52%)
		C2H2 Zn finger	614..634	CDD:275368	10/19 (53%)
		zf-H2C2_2	626..650	CDD:290200	11/23 (48%)
		C2H2 Zn finger	642..662	CDD:275368	8/19 (42%)
		zf-H2C2_2	657..678	CDD:290200	9/20 (45%)
		C2H2 Zn finger	670..690	CDD:275368	7/19 (37%)
		zf-H2C2_2	682..707	CDD:290200	11/24 (46%)
		C2H2 Zn finger	698..718	CDD:275368	9/19 (47%)
		C2H2 Zn finger	726..746	CDD:275368	10/20 (50%)
		zf-H2C2_2	739..763	CDD:290200	14/24 (58%)
		zf-C2H2	752..774	CDD:278523	10/21 (48%)
		C2H2 Zn finger	754..774	CDD:275368	10/19 (53%)
		zf-H2C2_2	766..789	CDD:290200	10/26 (38%)
		C2H2 Zn finger	782..802	CDD:275368	9/19 (47%)
		C2H2 Zn finger	810..830	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860