DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF611

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001154971.1	Gene:	ZNF611 / 81856	HGNCID:	28766	Length:	705	Species:	Homo sapiens

Alignment Length:	479	Identity:	181/479 - (37%)
Similarity:	251/479 - (52%)	Gaps:	34/479 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            ||:|||:|.....|..|.|.|:..||:.|:.||:.|:....||.|.::|.|...:.|..|..:|.
Human   261 CDVCGKLFNHEQYLACHDRCHTVEKPYKCKECGKTFSQESSLTCHRRLHTGVKRYNCNECGKIFG 325

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            .|::|.......:.:.|:.|..|.|.|.::..|.:| |.||||.|::|:.|.|.|:||..:..|.
Human   326 QNSALLIDKAIDTGENPYKCNECDKAFNQQSQLSHH-RIHTGEKPYKCEECDKVFSRKSTIETHK 389

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            |.||||.|:||.:|..:||          ||:                  .||.|.|.||.:..:
Human   390 RIHTGEKPYRCKVCDTAFT----------WHS------------------QLARHRRIHTAKKTY 426

  Fly   418 RCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTF 482
            :|..|||:||.|.....|...|.||..::|..|.|.|.....|..|.|...||.|::|:.|.|||
Human   427 KCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAFVWSSQLAKHTRIDCGEKPYKCNECGKTF 491

  Fly   483 TRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNH 547
            .:...|:.|...||||.|:||..|.|.|:||..:..|...||||.|:||..|.|.|....:|..|
Human   492 GQNSDLLIHKSIHTGEQPYKCDECEKVFSRKSSLETHKIGHTGEKPYKCKVCDKAFACHSYLAKH 556

  Fly   548 VRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNP 612
            .|.|:|:.|::|:.|.|||:.:.:|..|.|:|:|:.|:||..|.|||:|:..|:.|.|.||.:.|
Human   557 TRIHSGEKPYKCNECSKTFSHRSYLVCHHRVHSGEKPYKCNECSKTFSRRSSLHCHRRLHSGEKP 621

  Fly   613 HCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACE 677
            :.||.|...|.....||.| .|.|||::.:.|..|.|:|.....|..|.|.||    .|:|:.|.
Human   622 YKCNECGNTFRHCSSLIYH-RRLHTGEKSYKCTICDKAFVRNSLLSRHTRIHT----AEKPYKCN 681

  Fly   678 KCPKNFICKGHLVSHMRSHSGEKP 701
            :|.|.|..:.||..|.|.|:||||
Human   682 ECGKAFNQQSHLSRHHRIHTGEKP 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	155/402 (39%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF611	NP_001154971.1	KRAB	24..60	CDD:279668
		KRAB	24..>60	CDD:214630
		C2H2 Zn finger	233..253	CDD:275368
		COG5048	256..698	CDD:227381	175/470 (37%)
		C2H2 Zn finger	261..281	CDD:275368	9/19 (47%)
		C2H2 Zn finger	289..309	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..364	CDD:275368	7/19 (37%)
		zf-H2C2_2	359..381	CDD:290200	11/22 (50%)
		C2H2 Zn finger	372..392	CDD:275368	8/19 (42%)
		C2H2 Zn finger	400..420	CDD:275368	10/47 (21%)
		C2H2 Zn finger	428..448	CDD:275368	8/19 (42%)
		C2H2 Zn finger	456..475	CDD:275368	6/18 (33%)
		C2H2 Zn finger	484..504	CDD:275368	7/19 (37%)
		C2H2 Zn finger	512..532	CDD:275368	7/19 (37%)
		zf-H2C2_2	524..549	CDD:290200	11/24 (46%)
		C2H2 Zn finger	540..560	CDD:275368	7/19 (37%)
		zf-H2C2_2	552..577	CDD:290200	11/24 (46%)
		C2H2 Zn finger	568..588	CDD:275368	8/19 (42%)
		C2H2 Zn finger	596..616	CDD:275368	9/19 (47%)
		C2H2 Zn finger	624..644	CDD:275368	8/20 (40%)
		C2H2 Zn finger	652..672	CDD:275368	7/19 (37%)
		zf-H2C2_2	665..689	CDD:290200	11/27 (41%)
		C2H2 Zn finger	680..700	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860