DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF34

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_085057.3	Gene:	ZNF34 / 80778	HGNCID:	13098	Length:	560	Species:	Homo sapiens

Alignment Length:	606	Identity:	184/606 - (30%)
Similarity:	257/606 - (42%)	Gaps:	131/606 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VVTTGGTTITLGGPPPLPKS---EHKEDGKPP--------HGIEMYKVNIEDISQLFTYHEVFGK 70
            ::.|.|..::||..|..||.   ...|.|..|        .|.|..:||...:.....|.|:
Human    64 MLETYGNLVSLGVGPAGPKPGVISQLERGDEPWVLDVQGTSGKEHLRVNSPALGTRTEYKEL--- 125

  Fly    71 IHGDVVNHQLAAAHGGQLPPPPPLPPQVTSHAASAAAAAAAASTNNAAVAAVMASANAAAAAAAA 135
                     .:....|:..|....|.:...|.:.:.
Human   126 ---------TSQETFGEEDPQGSEPVEACDHISKSE----------------------------- 152

  Fly   136 ASAGGGLPPATSGNGGQQVTVTTTSSSTSSGGSTTSGGTTTTAGELLMPKMEGGIHGVDGSGNGG 200
                |.|.......|.:.||:|...||..|||
Human   153 ----GSLEKLVEQRGPRAVTLTNGESSRESGG--------------------------------- 180

  Fly   201 NGGGQNVAL----APDGTPIATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTS 261
                 |:.|    .||..|     |.||||.:.|:.|..|..|:|.|..:|....:..|:
Human   181 -----NLRLLSRPVPDQRP-----HKCDICEQSFEQRSYLNNHKRVHRSKKTNTVRNSGE----- 230

  Fly   262 QDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRS 326
                                   :|:.|..::...|..:..|...|:.|.|||....:|..|.|.
Human   231 -----------------------IFSANLVVKEDQKIPTGKKLHYCSYCGKTFRYSANLVKHQRL 272

  Fly   327 HTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQC 391
            ||.|.|::|..|.|.|::....:||.|.|:||.|:|||.|.|:|||:.:.:.|...|||:.|::|
Human   273 HTEEKPYKCDECGKAFSQSCEFINHRRMHSGEIPYRCDECGKTFTRRPNLMKHQRIHTGEKPYKC 337

  Fly   392 DVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTR 456
            ..|||.::....|..|.|.||.|.|::|..|||:||.......|...||||.|..|..|.|.||:
Human   338 GECGKHFSAYSSLIYHQRIHTGEKPYKCNDCGKAFSDGSILIRHRRTHTGEKPFECKECGKGFTQ 402

  Fly   457 KEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVR 521
            ..:|:.|.|.||||.|::|:.|.|.|.:|..||.|.|.||||.|::|..|.|.|::..|::.|.|
Human   403 SSNLIQHQRIHTGEKPYKCNECEKAFIQKTKLVEHQRSHTGEKPYECNDCGKVFSQSTHLIQHQR 467

  Fly   522 QHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHK 586
            .||||.|:||:.|.|.|.....|.:|.|.|.|:.|:|||.|||.|::..:|..|.|:|||:.|:|
Human   468 IHTGEKPYKCSECGKAFHNSSRLIHHQRLHHGEKPYRCSDCKKAFSQSTYLIQHRRIHTGEKPYK 532

  Fly   587 CEYCQKTFTRKEHLNNHMRQH 607
            |..|.|.|....::..|.|.|
Human   533 CSECGKAFRHSSNMCQHQRIH 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	251..271	CDD:275368	1/19 (5%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	132/308 (43%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF34	NP_085057.3	KRAB	35..97	CDD:214630	10/32 (31%)
		KRAB	35..74	CDD:279668	2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..188		11/62 (18%)
		COG5048	188..554	CDD:227381	151/399 (38%)
		C2H2 Zn finger	197..217	CDD:275368	9/19 (47%)
		zf-C2H2	251..273	CDD:278523	8/21 (38%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		zf-H2C2_2	265..290	CDD:290200	11/24 (46%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-C2H2	307..329	CDD:278523	9/21 (43%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		zf-H2C2_2	321..345	CDD:290200	9/23 (39%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		zf-H2C2_2	349..373	CDD:290200	11/23 (48%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		zf-H2C2_2	378..402	CDD:290200	10/23 (43%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		zf-H2C2_2	405..430	CDD:290200	12/24 (50%)
		C2H2 Zn finger	421..441	CDD:275368	9/19 (47%)
		zf-H2C2_2	434..458	CDD:290200	13/23 (57%)
		C2H2 Zn finger	449..469	CDD:275368	7/19 (37%)
		zf-H2C2_2	461..486	CDD:290200	13/24 (54%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		zf-H2C2_2	493..514	CDD:290200	12/20 (60%)
		C2H2 Zn finger	505..525	CDD:275368	9/19 (47%)
		zf-H2C2_2	517..542	CDD:290200	12/24 (50%)
		C2H2 Zn finger	533..553	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910