DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF430

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_079465.3	Gene:	ZNF430 / 80264	HGNCID:	20808	Length:	570	Species:	Homo sapiens

Alignment Length:	450	Identity:	160/450 - (35%)
Similarity:	223/450 - (49%)	Gaps:	32/450 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 IATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQ-DLTRHGKIHIGGPMFTC 279
            :.||....|.|.          :|:..:.|        ..|..||:| ::.::.|.
Human   145 LRTGCKSVDECN----------LHKECYDE--------LNQCLTTTQSEIFQYDKY--------- 182

  Fly   280 IVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTR 344
               .|||...::......||:..|||.|..|.|:|....||..|.|.|..|..::|:.|.|.|..
Human   183 ---VNVFYKFSNPNIQKIRHTGKKPFKCKKCDKSFCMLLHLTQHKRIHIRENSYQCEECGKVFNW 244

  Fly   345 KEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMR 409
            ...:..|.|.||||.|::|:.|.|:|.:......|.:.|||:.|::|:.|||.:.|..||..|.|
Human   245 FSTLTRHRRIHTGEKPYKCEQCGKAFKQSSTLTTHKIIHTGEKPYRCEECGKTFNRSSHLTTHKR 309

  Fly   410 SHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHR 474
            .||.|.|:|||.||::|:|..|.|.|.:.||||.|::|:.|.|.|.:...|..|...|.||.|::
Human   310 IHTGEKPYRCEECGRAFNRSSHLTTHKIIHTGEKPYKCEECGKAFNQSSTLTTHKIIHAGEKPYK 374

  Fly   475 CSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFT 539
            |..|.|.|.|..:|..|...||||..:||..|.|.|.....:..|.|.||||.|:||..|.|.|.
Human   375 CEECGKAFYRFSYLTKHKIIHTGEKFYKCEECGKGFNWSSTLTKHKRIHTGEKPYKCEQCGKAFN 439

  Fly   540 RKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHM 604
            ...:||.|...|||:.|::|..|.|.|.|...||.|..:|:|:.|:|||.|.|.|.:..:|..|.
Human   440 ESSNLTAHKIIHTGEKPYKCEECGKAFNRSPKLTAHKVIHSGEKPYKCEECGKAFNQFSNLTKHK 504

  Fly   605 RQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSH 664
            ..|..|..:....|:|.|::...|..| ...|||::|:.||..||:|....||:....|:
Human   505 ITHIGDTSYKYLECDKAFSQSSTLTKH-KVIHTGEKPYNCEEYGKAFNQSSNLIEQSNSY 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	3/19 (16%)
		C2H2 Zn finger	251..271	CDD:275368	5/20 (25%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	144/364 (40%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	5/20 (25%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF430	NP_079465.3	KRAB	35..96	CDD:214630
		KRAB	35..74	CDD:279668
		COG5048	202..562	CDD:227381	143/360 (40%)
		C2H2 Zn finger	207..227	CDD:275368	8/19 (42%)
		C2H2 Zn finger	235..255	CDD:275368	6/19 (32%)
		zf-H2C2_2	248..272	CDD:290200	11/23 (48%)
		C2H2 Zn finger	263..283	CDD:275368	5/19 (26%)
		zf-H2C2_2	276..300	CDD:290200	9/23 (39%)
		C2H2 Zn finger	291..311	CDD:275368	9/19 (47%)
		zf-H2C2_2	303..328	CDD:290200	14/24 (58%)
		C2H2 Zn finger	319..339	CDD:275368	9/19 (47%)
		zf-H2C2_2	331..356	CDD:290200	12/24 (50%)
		C2H2 Zn finger	347..367	CDD:275368	6/19 (32%)
		C2H2 Zn finger	375..395	CDD:275368	7/19 (37%)
		C2H2 Zn finger	403..423	CDD:275368	6/19 (32%)
		zf-H2C2_2	416..439	CDD:290200	11/22 (50%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		zf-H2C2_2	443..468	CDD:290200	11/24 (46%)
		C2H2 Zn finger	459..479	CDD:275368	8/19 (42%)
		zf-H2C2_2	472..496	CDD:290200	12/23 (52%)
		C2H2 Zn finger	487..507	CDD:275368	7/19 (37%)
		C2H2 Zn finger	515..535	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810