DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF614

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_079316.2	Gene:	ZNF614 / 80110	HGNCID:	24722	Length:	585	Species:	Homo sapiens

Alignment Length:	499	Identity:	180/499 - (36%)
Similarity:	246/499 - (49%)	Gaps:	37/499 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 HRRYHSERKPFM--CQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANN----TSLERHMK 297
            |.:.||..:..:  .|.| .|..|.:::....|.|.  |:......|:::..|    .||....:
Human    87 HLQEHSPNQRLLKSVQQC-NGQNTLRNIVHLSKTHF--PIVQNHDTFDLYRKNLKSSLSLINQKR 148

  Fly   298 RHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHR 362
            ||..:.|......:||....:|...|.::...|.       ||....|..:..|.|....|.||.
Human   149 RHGINNPVEFIGGEKTLLHGKHERTHTKTRFSEN-------AKCIHTKFQVFKHQRTQKIEKPHA 206

  Fly   363 CDICKKSFTRKEHYVNHYMWHTGQTP--HQCDVCGKKYTRKEHLANHMRSHTNETPFRCEIC--- 422
            |..|:::|.||...:.|......:.|  .||:    |.:|......|::::|.:     :||
Human   207 CIECEQTFLRKSQLIYHENICIQENPGSGQCE----KLSRSVLFTKHLKTNTTD-----KICIPN 262

  Fly   423 --GKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRK 485
              .|..:.|.....|...||.|..:.|..|.|.||.|.:|:.|.|.|:||.|:.|..|.|.||.|
Human   263 EYRKGSTVKSSLITHQQTHTEEKSYMCSECGKGFTMKRYLIAHQRTHSGEKPYVCKECGKGFTVK 327

  Fly   486 EHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQ 550
            .:|:.|.|.||||.|:.|:.|.|.||.|.::|.|.|.||||.|:.|:.|.|.||.|.:|..|.|.
Human   328 SNLIVHQRTHTGEKPYICSECGKGFTMKRYLVVHQRTHTGEKPYMCSECGKGFTVKSNLIVHQRS 392

  Fly   551 HTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCC 615
            |||:..:.||.|.|.||.|..|..|.|.|||:..:.|..|.|.||.|..|..|.|.|:.:.|:.|
Human   393 HTGEKSYICSECGKGFTVKRTLVIHQRTHTGEKSYICNECGKGFTTKRTLIIHQRTHTGEKPYEC 457

  Fly   616 NVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCP 680
            |.|.|.|::|..||.| .|||||..||.|..||||:..|..|:.|||.||.    |:|:.|.:|.
Human   458 NECGKAFSQKICLIQH-ERCHTGKTPFVCTECGKSYSHKYGLITHQRIHTG----EKPYECNECG 517

  Fly   681 KNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            |.|..|..|..|.|:|:||:|:.|:.|.|||....||.:|.||:
Human   518 KAFTTKSVLNVHQRTHTGERPYGCSDCEKAFSHLSNLVKHKKMH 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	1/3 (33%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	4/23 (17%)
		COG5048	300..723	CDD:227381	162/429 (38%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		C2H2 Zn finger	419..439	CDD:275368	5/24 (21%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	10/19 (53%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	10/20 (50%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
ZNF614	NP_079316.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	<92..350	CDD:227381	78/276 (28%)
		C2H2 Zn finger	180..199	CDD:275368	6/25 (24%)
		C2H2 Zn finger	207..226	CDD:275368	6/18 (33%)
		C2H2 Zn finger	236..253	CDD:275368	5/20 (25%)
		C2H2 Zn finger	289..309	CDD:275368	9/19 (47%)
		zf-H2C2_2	301..325	CDD:290200	10/23 (43%)
		C2H2 Zn finger	317..337	CDD:275368	9/19 (47%)
		zf-H2C2_2	329..353	CDD:290200	11/23 (48%)
		C2H2 Zn finger	345..365	CDD:275368	9/19 (47%)
		zf-H2C2_2	357..381	CDD:290200	11/23 (48%)
		C2H2 Zn finger	373..393	CDD:275368	9/19 (47%)
		COG5048	<383..562	CDD:227381	83/184 (45%)
		C2H2 Zn finger	401..421	CDD:275368	10/19 (53%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		zf-H2C2_2	442..466	CDD:290200	10/23 (43%)
		C2H2 Zn finger	457..477	CDD:275368	10/20 (50%)
		C2H2 Zn finger	485..505	CDD:275368	10/19 (53%)
		zf-H2C2_2	498..522	CDD:290200	12/27 (44%)
		C2H2 Zn finger	513..533	CDD:275368	8/19 (42%)
		C2H2 Zn finger	541..561	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810