DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and ZNF442

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_016882805.1	Gene:	ZNF442 / 79973	HGNCID:	20877	Length:	635	Species:	Homo sapiens

Alignment Length:	509	Identity:	175/509 - (34%)
Similarity:	249/509 - (48%)	Gaps:	34/509 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 HVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNV 285
            |....||..|.:.:......|.|:.:|.:.|:.||:.|::|.:|.||..:..||
Human   161 HTHKQCGTAFNYHHSFQTQERPHTGKKRYDCKECGKTFSSSGNLRRHIIVQRGG----------- 214

  Fly   286 FANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVN 350
                             .|:.|.:|.|.|........|.|:||||.|:.|:.|.|.|......:.
Human   215 -----------------GPYICKLCGKAFFWPSLFRMHERTHTGEKPYECKQCCKAFPIYSSYLR 262

  Fly   351 HVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNET 415
            |.|.||||.|:.|..|.|:|.....||.|...|||:.|::|..||:.::....|..|.|:||.|.
Human   263 HERTHTGEKPYECKHCSKAFPDYSSYVRHERTHTGEKPYKCKRCGRAFSVSSSLRIHERTHTGEK 327

  Fly   416 PFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMK 480
            |:.|:.|||:|.....|..|::.|||:.||:|..|.|.|.....|.:|.|.||||.|:.|..|.|
Human   328 PYECKQCGKAFHHLGSFQRHMIRHTGDGPHKCKICGKGFDCPSSLQSHERTHTGEKPYECKQCGK 392

  Fly   481 TFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLT 545
            ..:......:|:..|||:.|.||..|.|||........|.|.||||.|::|..|.|.|.....|.
Human   393 ALSHHSSFRSHMIMHTGDGPHKCKVCGKAFIYPSVFQGHERTHTGEKPYECKECGKAFRISSSLR 457

  Fly   546 NHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSD 610
            .|...|||:.|::|. |.|.|.......||...|||:.|::|:.|.|.|:...:|:.|.|.|.::
Human   458 RHETTHTGEKPYKCK-CGKAFIDFYSFQNHETTHTGEKPYECKECGKAFSCFTYLSQHRRTHMAE 521

  Fly   611 NPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFA 675
            .|:.|..|.|.|:...:|..| .|.|||::|:.|:.|.|:|.....||.|:|.||.    ::.:.
Human   522 KPYECKTCKKAFSHFGNLKVH-ERIHTGEKPYECKECRKAFSWLTCLLRHERIHTG----KKSYE 581

  Fly   676 CEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNHPDAM 729
            |::|.|.|.....|..|.::|:|||.|.|..|.||.....:|.||.:.:..|.:
Human   582 CQQCGKAFTRSRFLRGHEKTHTGEKMHECKECGKALSSLSSLHRHKRTHWRDTL 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		C2H2 Zn finger	279..299	CDD:275368	0/19 (0%)
		COG5048	300..723	CDD:227381	157/422 (37%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	4/19 (21%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	6/19 (32%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF442	XP_016882805.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810