DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF229

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_055333.3	Gene:	ZNF229 / 7772	HGNCID:	13022	Length:	825	Species:	Homo sapiens

Alignment Length:	514	Identity:	196/514 - (38%)
Similarity:	272/514 - (52%)	Gaps:	20/514 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 GGQNVALAPDGTPIATGTHV--------------CDICGKMFQFRYQLIVHRRYHSERKPFMCQV 253
            |.::|.....|..:...||:              ||:|||.|:::..|::|:..|:.|:|:.|:.
Human   317 GEKSVKSLERGRGVRQNTHIRNHPRAPVGDMPYRCDVCGKGFRYKSVLLIHQGVHTGRRPYKCEE 381

  Fly   254 CGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKE 318
            ||:.|..|.:|..|.::|.|...:.|..|...|:.::.|:.|.:.|:.:||:.|:.|.|.|..|.
Human   382 CGKAFGRSSNLLVHQRVHTGEKPYKCSECGKGFSYSSVLQVHQRLHTGEKPYTCSECGKGFCAKS 446

  Fly   319 HLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWH 383
            .|..|...|.||.|:.|..|.|.|:...|:.:|.:.||||.|::||.|.|.|:...:...|...|
Human   447 ALHKHQHIHPGEKPYSCGECGKGFSCSSHLSSHQKTHTGERPYQCDKCGKGFSHNSYLQAHQRVH 511

  Fly   384 TGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCD 448
            .||..::|:||||.::....|..|.|.||.|.|::|| |||||.|......|...||||.|::|.
Human   512 MGQHLYKCNVCGKSFSYSSGLLMHQRLHTGEKPYKCE-CGKSFGRSSDLHIHQRVHTGEKPYKCS 575

  Fly   449 FCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRK 513
            .|.|.|.|...|.:|.|.||||.|:.|..|.|.|.....|:.|.|.||||.|:||..|.|.|:..
Human   576 ECGKGFRRNSDLHSHQRVHTGERPYVCDVCGKGFIYSSDLLIHQRVHTGEKPYKCAECGKGFSYS 640

  Fly   514 DHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRL 578
            ..::.|.|.||||.|::|..|.|.|.....|..|.|.|||..|:.|..|.|.|:...:|..|.||
Human   641 SGLLIHQRVHTGEKPYRCQECGKGFRCTSSLHKHQRVHTGKKPYTCDQCGKGFSYGSNLRTHQRL 705

  Fly   579 HTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFT 643
            |||:.|:.|..|.|.|.....|.:|.|.|:.:.|:.|:||.|.:::..||..| .|.|||::|:.
Human   706 HTGEKPYTCCECGKGFRYGSGLLSHKRVHTGEKPYRCHVCGKGYSQSSHLQGH-QRVHTGEKPYK 769

  Fly   644 CETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPH 702
            ||.|||.|.....|..|||.||.    |:|:.|..|.|.|.....|.:|.|.|.||.|:
Human   770 CEECGKGFGRNSCLHVHQRVHTG----EKPYTCGVCGKGFSYTSGLRNHQRVHLGENPY 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	165/403 (41%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF229	NP_055333.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		KRAB	34..>74	CDD:214630
		KRAB	34..73	CDD:279668
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		COG5048	375..787	CDD:227381	163/413 (39%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	7/24 (29%)
		C2H2 Zn finger	407..427	CDD:275368	5/19 (26%)
		zf-H2C2_2	420..442	CDD:290200	8/21 (38%)
		C2H2 Zn finger	435..455	CDD:275368	7/19 (37%)
		C2H2 Zn finger	463..483	CDD:275368	6/19 (32%)
		zf-H2C2_2	475..500	CDD:290200	12/24 (50%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	519..539	CDD:275368	8/19 (42%)
		C2H2 Zn finger	547..566	CDD:275368	9/19 (47%)
		zf-H2C2_2	562..583	CDD:290200	10/20 (50%)
		C2H2 Zn finger	574..594	CDD:275368	8/19 (42%)
		zf-H2C2_2	589..611	CDD:290200	11/21 (52%)
		C2H2 Zn finger	602..622	CDD:275368	7/19 (37%)
		zf-H2C2_2	614..639	CDD:290200	13/24 (54%)
		C2H2 Zn finger	630..650	CDD:275368	6/19 (32%)
		zf-H2C2_2	643..667	CDD:290200	11/23 (48%)
		C2H2 Zn finger	658..678	CDD:275368	7/19 (37%)
		zf-H2C2_2	673..695	CDD:290200	10/21 (48%)
		C2H2 Zn finger	686..706	CDD:275368	7/19 (37%)
		zf-H2C2_2	698..723	CDD:290200	12/24 (50%)
		C2H2 Zn finger	714..734	CDD:275368	7/19 (37%)
		zf-H2C2_2	727..751	CDD:290200	9/23 (39%)
		C2H2 Zn finger	742..762	CDD:275368	8/20 (40%)
		zf-H2C2_2	754..779	CDD:290200	14/25 (56%)
		C2H2 Zn finger	770..790	CDD:275368	10/19 (53%)
		zf-H2C2_2	785..807	CDD:290200	11/25 (44%)
		C2H2 Zn finger	798..818	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.950