DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF112

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001335210.1	Gene:	ZNF112 / 7771	HGNCID:	12892	Length:	930	Species:	Homo sapiens

Alignment Length:	506	Identity:	190/506 - (37%)
Similarity:	266/506 - (52%)	Gaps:	31/506 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 GKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTS---QDLTRHGKIHIGGPMFTCIVCFNVFAN 288
            ||.|.....|.:..|.|.|...:..:.||.||:.:   |||.   .:|.....:...||.|.|::
Human   438 GKSFICSSNLDIQHRVHMEENSYNSEECGNGFSLASHFQDLQ---IVHTKEQPYKRYVCSNSFSH 499

  Fly   289 NTSLERHMKRHSTDKPFACTICQKTFARKEH---------LDNHFRSHTGETPFRCQYCAKTFTR 344
            |..|:.|.|.|..:||           ||||         |.:|.|.|||:.|::|..|.|.|..
Human   500 NLYLQGHPKIHIGEKP-----------RKEHGNGFNWSSKLKDHQRVHTGQKPYKCNICGKGFNH 553

  Fly   345 KEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMR 409
            :..:..|.|.||||.|::|:.|.|.|:|..:...|...|||:.|::|:.|||.::|..:|..|.|
Human   554 RSVLNVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQRVHTGEKPYKCEECGKGFSRNSYLQGHQR 618

  Fly   410 SHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHR 474
            .||.|.|::||.|||.|||..|...|...||||.|.:|:.|.|.|:...:|..|.|.||||.|::
Human   619 VHTGEKPYKCEECGKGFSRSSHLQGHQRVHTGEKPFKCEECGKGFSWSFNLQIHQRVHTGEKPYK 683

  Fly   475 CSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFT 539
            |..|.|.|::...|:.|.|.||||.|::|..|.|:|:::.::.:|...|:||.|:.|..|.|.|:
Human   684 CEECGKGFSKASTLLAHQRVHTGEKPYQCDECGKSFSQRSYLQSHQSVHSGERPYICEVCGKGFS 748

  Fly   540 RKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHM 604
            ::.:|..|.|.||...|::|..|.|.|::...|..|.|:|||..|:|||.|.|.|:....|..|.
Human   749 QRAYLQGHQRVHTRVKPYKCEMCGKGFSQSSRLEAHRRVHTGGKPYKCEVCTKGFSESSRLQAHQ 813

  Fly   605 RQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQE 669
            |.|....|:.|..|.|.|:....|..| .|.|||::|:.||.|||.|..:.||..|||.||.
Human   814 RVHVEGRPYKCEQCGKGFSGYSSLQAH-HRVHTGEKPYKCEVCGKGFSQRSNLQAHQRVHTG--- 874

  Fly   670 MERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRH 720
             |:|:.|:.|.|.|.....|:.|.|.||.:|.:......|.:....||.|:
Human   875 -EKPYKCDACGKGFRWSSGLLIHQRVHSSDKFYKSEDYGKDYPSSENLHRN 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/15 (33%)
		C2H2 Zn finger	251..271	CDD:275368	7/22 (32%)
		C2H2 Zn finger	279..299	CDD:275368	8/19 (42%)
		COG5048	300..723	CDD:227381	166/430 (39%)
		C2H2 Zn finger	307..327	CDD:275368	7/28 (25%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	11/19 (58%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	4/17 (24%)
ZNF112	NP_001335210.1	KRAB	25..85	CDD:214630
		C2H2 Zn finger	250..269	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	305..321	CDD:275368
		C2H2 Zn finger	350..370	CDD:275368
		COG5048	401..773	CDD:227381	130/348 (37%)
		C2H2 Zn finger	406..426	CDD:275368
		C2H2 Zn finger	434..454	CDD:275368	5/15 (33%)
		C2H2 Zn finger	462..482	CDD:275368	7/22 (32%)
		C2H2 Zn finger	520..536	CDD:275368	3/15 (20%)
		C2H2 Zn finger	544..564	CDD:275368	6/19 (32%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		C2H2 Zn finger	628..648	CDD:275368	10/19 (53%)
		C2H2 Zn finger	656..676	CDD:275368	7/19 (37%)
		C2H2 Zn finger	684..704	CDD:275368	7/19 (37%)
		C2H2 Zn finger	712..732	CDD:275368	5/19 (26%)
		C2H2 Zn finger	740..760	CDD:275368	7/19 (37%)
		C2H2 Zn finger	768..788	CDD:275368	7/19 (37%)
		SFP1	<780..873	CDD:227516	40/93 (43%)
		C2H2 Zn finger	796..816	CDD:275368	8/19 (42%)
		C2H2 Zn finger	824..844	CDD:275368	7/20 (35%)
		C2H2 Zn finger	852..872	CDD:275368	11/19 (58%)
		zf-H2C2_2	864..888	CDD:316026	12/27 (44%)
		C2H2 Zn finger	880..900	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860