DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF227

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001276095.1	Gene:	ZNF227 / 7770	HGNCID:	13020	Length:	799	Species:	Homo sapiens

Alignment Length:	575	Identity:	203/575 - (35%)
Similarity:	292/575 - (50%)	Gaps:	58/575 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 GNGGGQNVALAPDGT----PIATGTHVCDICGKMFQFRYQLIVH--------------------- 239
            ||..|:.::   ||:    |:....|.|..||:.|.:..:|.:|
Human   228 GNEYGKIIS---DGSNQKLPLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQR 289

  Fly   240 -------------------------RRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTC 279
                                     :..|:..|.:.|..||:||::|..|..|.:.|.|...:.|
Human   290 IHPGEKLNRCHESGDCFNKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKPYKC 354

  Fly   280 IVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTR 344
            ..|...|:.:::.:.|.:.|:.:||:.|..|.|.|....:|..|.|.|.||.|::|:.|.|.||:
Human   355 EECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFGWSVNLRVHQRVHRGEKPYKCEECGKGFTQ 419

  Fly   345 KEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMR 409
            ..|...|.|.||||.|::||:|.|.|:.....:.|...|||:.|::|:.|||.:||...|..|.|
Human   420 AAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHFR 484

  Fly   410 SHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHR 474
            .||.|.|::|:.|||.||:..:...|...||||...:|:.|.|.|::...|..|.|.||||.|:|
Human   485 VHTGEKPYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYR 549

  Fly   475 CSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFT 539
            |..|.|.|:...:|..|...||||.|:||..|.|.|:.:.::..|.|.|:||.|:||..|.|:|:
Human   550 CDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGFSWRSNLHAHQRVHSGEKPYKCEQCDKSFS 614

  Fly   540 RKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHM 604
            :......|.|.|||:.|::|..|.|.|::...|.:|.|:|||:.|:||:.|.|.|........|.
Human   615 QAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEKPYKCDVCGKGFRYSSQFIYHQ 679

  Fly   605 RQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQE 669
            |.|:.:.|:.|..|.|.|.|..:| .|..|.|||::|..||.|||:|.|..||..|...||:
Human   680 RGHTGEKPYKCEECGKGFGRSLNL-RHHQRVHTGEKPHICEECGKAFSLPSNLRVHLGVHTR--- 740

  Fly   670 MERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
             |:.|.||:|.|.|.....|.:|.|.|:||||:.|.:|.|.|..|..|..|.|::
Human   741 -EKLFKCEECGKGFSQSARLEAHQRVHTGEKPYKCDICDKDFRHRSRLTYHQKVH 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	6/65 (9%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		C2H2 Zn finger	279..299	CDD:275368	4/19 (21%)
		COG5048	300..723	CDD:227381	172/422 (41%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF227	NP_001276095.1	KRAB	23..83	CDD:214630
		C2H2 Zn finger	326..346	CDD:275368	8/19 (42%)
		zf-H2C2_2	342..363	CDD:316026	6/20 (30%)
		C2H2 Zn finger	354..374	CDD:275368	4/19 (21%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		COG5048	406..779	CDD:227381	155/377 (41%)
		C2H2 Zn finger	410..430	CDD:275368	8/19 (42%)
		C2H2 Zn finger	438..458	CDD:275368	6/19 (32%)
		C2H2 Zn finger	466..486	CDD:275368	9/19 (47%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	578..598	CDD:275368	6/19 (32%)
		C2H2 Zn finger	606..626	CDD:275368	6/19 (32%)
		C2H2 Zn finger	634..654	CDD:275368	7/19 (37%)
		C2H2 Zn finger	662..682	CDD:275368	6/19 (32%)
		C2H2 Zn finger	690..710	CDD:275368	8/20 (40%)
		C2H2 Zn finger	718..738	CDD:275368	10/19 (53%)
		C2H2 Zn finger	746..766	CDD:275368	8/19 (42%)
		C2H2 Zn finger	774..794	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860