DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF195

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001123992.1	Gene:	ZNF195 / 7748	HGNCID:	12986	Length:	629	Species:	Homo sapiens

Alignment Length:	434	Identity:	148/434 - (34%)
Similarity:	211/434 - (48%)	Gaps:	15/434 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            |..|...|.|....:|      ..|.|....:|.....|:|||.||:||.|.|:|.....:..|.
Human   205 NQCSSTTHSKIFQYNK------YVKIFDNFSNLHRRNISNTGEKPFKCQECGKSFQMLSFLTEHQ 263

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            :.|||:...:|..|.|:|.:..|:.......||:.|::|..|.........|..: |.:.....:
Human   264 KIHTGKKFQKCGECGKTFIQCSHFTEPENIDTGEKPYKCQECNNVIKTCSVLTKN-RIYAGGEHY 327

  Fly   418 RCEICGKSFSRKEHFTNHILWH-TGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKT 481
            |||..||.|::..|.|.|  .| |.|.|.:.:.||..|.....|.|......||...:|....|.
Human   328 RCEEFGKVFNQCSHLTEH--EHGTEEKPCKYEECSSVFISCSSLSNQQMILAGEKLSKCETWYKG 390

  Fly   482 FTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTN 546
            |....:...|.|...|..||||..|...|.....:..|.|.||||.|:||..|.|.:|:..||:.
Human   391 FNHSPNPSKHQRNEIGGKPFKCEECDSIFKWFSDLTKHKRIHTGEKPYKCDECGKAYTQSSHLSE 455

  Fly   547 HVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDN 611
            |.|.|||:.|::|..|.|.|.....|:||.|.|:.:.|:.||.|...|.:...|..|.:.|:.:.
Human   456 HRRIHTGEKPYQCEECGKVFRTCSSLSNHKRTHSEEKPYTCEECGNIFKQLSDLTKHKKTHTGEK 520

  Fly   612 PHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFAC 676
            |:.|:.|.|.||:..:||.| .|.|||::|:.||.||:.|....::..|:::||.    |:|:.|
Human   521 PYKCDECGKNFTQSSNLIVH-KRIHTGEKPYKCEECGRVFMWFSDITKHKKTHTG----EKPYKC 580

  Fly   677 EKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRH 720
            ::|.|||....:|:.|.|.|:||||:.|..|.|||.:..:|..|
Human   581 DECGKNFTQSSNLIVHKRIHTGEKPYKCEKCGKAFTQFSHLTVH 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368	4/10 (40%)
		COG5048	300..723	CDD:227381	144/422 (34%)
		C2H2 Zn finger	307..327	CDD:275368	3/19 (16%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	6/19 (32%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF195	NP_001123992.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		Spacer	76..243		12/43 (28%)
		COG5048	225..629	CDD:227381	142/408 (35%)
		C2H2 Zn finger	246..266	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		C2H2 Zn finger	302..345	CDD:275368	12/43 (28%)
		C2H2 Zn finger	384..404	CDD:275368	5/19 (26%)
		C2H2 Zn finger	412..432	CDD:275368	5/19 (26%)
		zf-H2C2_2	424..449	CDD:290200	11/24 (46%)
		C2H2 Zn finger	440..460	CDD:275368	8/19 (42%)
		zf-H2C2_2	452..477	CDD:290200	12/24 (50%)
		C2H2 Zn finger	468..488	CDD:275368	8/19 (42%)
		zf-H2C2_2	480..505	CDD:290200	10/24 (42%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		zf-H2C2_2	508..533	CDD:290200	8/24 (33%)
		C2H2 Zn finger	524..544	CDD:275368	9/20 (45%)
		zf-H2C2_2	536..559	CDD:290200	12/23 (52%)
		C2H2 Zn finger	552..572	CDD:275368	6/19 (32%)
		zf-H2C2_2	567..589	CDD:290200	10/25 (40%)
		C2H2 Zn finger	580..600	CDD:275368	8/19 (42%)
		zf-H2C2_2	592..617	CDD:290200	13/24 (54%)
		C2H2 Zn finger	608..628	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900