DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZSCAN9

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_011513177.1	Gene:	ZSCAN9 / 7746	HGNCID:	12984	Length:	583	Species:	Homo sapiens

Alignment Length:	360	Identity:	93/360 - (25%)
Similarity:	154/360 - (42%)	Gaps:	63/360 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 RYQLIVHRRYHSERKPFMCQ----VCGQGFTTSQDLTRHGKIHIGGPMFTC---IVCFNVFANN- 289
            :::::.||    .|:..:|:    :..|...|.|...:.       |..||   ..|.::....
Human   270 QHEMVAHR----HRQEVLCKEMVPLAEQTPLTLQSQPKE-------PQLTCDSAQKCHSIGETAP 323

  Fly   290 ---TSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNH 351
               :.|.|.::|.:...|...           ||                :...||...:.:|..
Human   324 LWISDLIRSLRRRAVLIPLGA-----------HL----------------FSTDTFLFSKPVVIP 361

  Fly   352 VRKHTGET-PHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNET 415
            ..|..||| |:...:.:...|:.|   :..:......|...:..||.:..:..      ..:.:.
Human   362 QLKGGGETWPNNRGVLRDEVTKTE---DRELVLRKDCPKIVEPHGKMFNEQTW------EVSQQD 417

  Fly   416 PFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMK 480
            |...|: |:...|.|....::|   ||..|:||.|.|:||:...|:.|.|.||||.|:.|:.|.|
Human   418 PSHGEV-GEHKDRIERQWGNLL---GEGQHKCDECGKSFTQSSGLIRHQRIHTGERPYECNECGK 478

  Fly   481 TFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLT 545
            .|:|...|.||...|..:..:.|..|.|.|::...::.|.|.|.||.|::|:.|:|:::|:..|.
Human   479 AFSRSSGLFNHRGIHNIQKRYHCKECGKVFSQSAGLIQHQRIHKGEKPYQCSQCSKSYSRRSFLI 543

  Fly   546 NHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHT 580
            .|.|.|||:.||:|..|.|:|.|..:|..|.::||
Human   544 EHQRSHTGERPHQCIECGKSFNRHCNLIRHQKIHT 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	2/9 (22%)
		C2H2 Zn finger	251..271	CDD:275368	4/23 (17%)
		C2H2 Zn finger	279..299	CDD:275368	4/26 (15%)
		COG5048	300..723	CDD:227381	79/282 (28%)
		C2H2 Zn finger	307..327	CDD:275368	2/19 (11%)
		C2H2 Zn finger	335..355	CDD:275368	3/19 (16%)
		C2H2 Zn finger	363..383	CDD:275368	2/19 (11%)
		C2H2 Zn finger	391..411	CDD:275368	2/19 (11%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZSCAN9	XP_011513177.1	SCAN	180..292	CDD:128708	4/25 (16%)
		SCAN	181..268	CDD:280241
		COG5048	<442..578	CDD:227381	53/135 (39%)
		zf-C2H2	443..465	CDD:278523	10/21 (48%)
		C2H2 Zn finger	445..465	CDD:275368	9/19 (47%)
		zf-H2C2_2	458..482	CDD:290200	12/23 (52%)
		C2H2 Zn finger	473..493	CDD:275368	8/19 (42%)
		zf-C2H2	499..521	CDD:278523	6/21 (29%)
		C2H2 Zn finger	501..521	CDD:275368	6/19 (32%)
		zf-H2C2_2	514..538	CDD:290200	9/23 (39%)
		C2H2 Zn finger	529..549	CDD:275368	7/19 (37%)
		zf-H2C2_2	542..566	CDD:290200	12/23 (52%)
		C2H2 Zn finger	557..577	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100