DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZSCAN26

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001018854.2	Gene:	ZSCAN26 / 7741	HGNCID:	12978	Length:	479	Species:	Homo sapiens

Alignment Length:	289	Identity:	98/289 - (33%)
Similarity:	144/289 - (49%)	Gaps:	12/289 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 GKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLD--NHFRSHTGE 330
            |::...|.:...:...|   ..::||||..:......:.|:..::.|.  :|||  .|..:|||:
Human   198 GRVESSGKISEPMEAHN---EGSNLERHQAKPKEKIEYKCSEREQRFI--QHLDLIEHASTHTGK 257

  Fly   331 TPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCG 395
                 :.|.....:...:..|.:..:.|..|:|..|.|:|.|..|.|.|...|.|:.|:||:.||
Human   258 -----KLCESDVCQSSSLTGHKKVLSREKGHQCHECGKAFQRSSHLVRHQKIHLGEKPYQCNECG 317

  Fly   396 KKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHL 460
            |.:::...|..|:|.||.|.|:.|..|||:|.|..|...|...|:.|.|..|..|.|||::...|
Human   318 KVFSQNAGLLEHLRIHTGEKPYLCIHCGKNFRRSSHLNRHQRIHSQEEPCECKECGKTFSQALLL 382

  Fly   461 LNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTG 525
            .:|.|.|:....|:|:.|.|.|:....|:.|.|.||||.||||..|.|||....|:..|||.|..
Human   383 THHQRIHSHSKSHQCNECGKAFSLTSDLIRHHRIHTGEKPFKCNICQKAFRLNSHLAQHVRIHNE 447

  Fly   526 ESPHKCTYCTKTFTRKEHLTNHVRQHTGD 554
            |.|::|:.|.:.|.::..|..|.|.|..|
Human   448 EKPYQCSECGEAFRQRSGLFQHQRYHHKD 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368	1/2 (50%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	91/257 (35%)
		C2H2 Zn finger	307..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	335..355	CDD:275368	2/19 (11%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368
		C2H2 Zn finger	587..607	CDD:275368
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZSCAN26	NP_001018854.2	SCAN	47..135	CDD:280241
		SCAN	52..158	CDD:128708
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..182
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..227		6/28 (21%)
		C2H2 Zn finger	234..254	CDD:275368	6/21 (29%)
		zf-C2H2	283..305	CDD:278523	9/21 (43%)
		C2H2 Zn finger	285..305	CDD:275368	8/19 (42%)
		COG5048	<290..469	CDD:227381	72/178 (40%)
		zf-H2C2_2	297..322	CDD:290200	11/24 (46%)
		C2H2 Zn finger	313..333	CDD:275368	7/19 (37%)
		zf-H2C2_2	326..350	CDD:290200	12/23 (52%)
		C2H2 Zn finger	341..361	CDD:275368	8/19 (42%)
		zf-H2C2_2	353..378	CDD:290200	10/24 (42%)
		C2H2 Zn finger	369..389	CDD:275368	8/19 (42%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..432	CDD:290200	13/22 (59%)
		C2H2 Zn finger	425..445	CDD:275368	9/19 (47%)
		zf-H2C2_2	437..462	CDD:290200	10/24 (42%)
		C2H2 Zn finger	453..473	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100