DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF175

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_009078.1	Gene:	ZNF175 / 7728	HGNCID:	12964	Length:	711	Species:	Homo sapiens

Alignment Length:	529	Identity:	186/529 - (35%)
Similarity:	258/529 - (48%)	Gaps:	39/529 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 GKMFQFRYQLIVHRRYHSERKPFMC--------------------------QVCGQG--FTTSQD 263
            |||.:.|..|.     .|:::|..|                          .|.|.|  |:.|..
Human   179 GKMIRTRPHLA-----SSQKQPQKCCLFTESLKLNLEVNGQNESNDTEQLDDVVGSGQLFSHSSS 238

  Fly   264 LTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHT 328
            ......||.|........|..|..:..||::| :.|:..||..|:.|..:|.:|.||....|.|:
Human   239 DACSKNIHTGETFCKGNQCRKVCGHKQSLKQH-QIHTQKKPDGCSECGGSFTQKSHLFAQQRIHS 302

  Fly   329 GETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDV 393
            ......|..|.|.|..:..:..::..|||:.|..|..|.|.|.::...:.|...||.:.|::|..
Human   303 VGNLHECGKCGKAFMPQLKLSVYLTDHTGDIPCICKECGKVFIQRSELLTHQKTHTRKKPYKCHD 367

  Fly   394 CGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKE 458
            |||.:.:...|..|.|:|:.|..:.|..|||.||:......|...||||..:.|..|.|.||:|.
Human   368 CGKAFFQMLSLFRHQRTHSREKLYECSECGKGFSQNSTLIIHQKIHTGERQYACSECGKAFTQKS 432

  Fly   459 HLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQH 523
            .|..|.|.|:|:..:.|..|.:.|.:|.||:.|.|.||||.|::|..|.|:|..|..:..|.|.|
Human   433 TLSLHQRIHSGQKSYVCIECGQAFIQKAHLIVHQRSHTGEKPYQCHNCGKSFISKSQLDIHHRIH 497

  Fly   524 TGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCE 588
            |||.|::|:.|.||||:|.||..|.:.|||:..|.||.|.|.|.:|..|:.|.|:|||:.|:||.
Human   498 TGEKPYECSDCGKTFTQKSHLNIHQKIHTGERHHVCSECGKAFNQKSILSMHQRIHTGEKPYKCS 562

  Fly   589 YCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPL 653
            .|.|.||.|.....|.|.|:.:.|:.|..|.|.|..:.:...|.. .||.:|||.|..|||:|..
Human   563 ECGKAFTSKSQFKEHQRIHTGEKPYVCTECGKAFNGRSNFHKHQI-THTRERPFVCYKCGKAFVQ 626

  Fly   654 KGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLK 718
            |..|:.|||:|..    |:|:.|..|.|:|..|..|..|.|.|:||:|:.|:.|.|||..|.|..
Human   627 KSELITHQRTHMG----EKPYECLDCGKSFSKKPQLKVHQRIHTGERPYVCSECGKAFNNRSNFN 687

  Fly   719 RHMKMNHPD 727
            :|...:..|
Human   688 KHQTTHTRD 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/15 (33%)
		C2H2 Zn finger	251..271	CDD:275368	6/47 (13%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	163/422 (39%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	4/19 (21%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	10/19 (53%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	5/20 (25%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
ZNF175	NP_009078.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		KRAB	27..85	CDD:214630
		C2H2 Zn finger	230..246	CDD:275368	3/15 (20%)
		C2H2 Zn finger	255..273	CDD:275368	5/18 (28%)
		COG5048	275..689	CDD:227381	162/418 (39%)
		C2H2 Zn finger	281..300	CDD:275368	6/18 (33%)
		C2H2 Zn finger	309..329	CDD:275368	4/19 (21%)
		C2H2 Zn finger	337..357	CDD:275368	5/19 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	359..362		0/2 (0%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		C2H2 Zn finger	421..441	CDD:275368	9/19 (47%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		C2H2 Zn finger	505..525	CDD:275368	10/19 (53%)
		C2H2 Zn finger	533..553	CDD:275368	9/19 (47%)
		C2H2 Zn finger	561..581	CDD:275368	8/19 (42%)
		C2H2 Zn finger	589..609	CDD:275368	5/20 (25%)
		C2H2 Zn finger	617..637	CDD:275368	10/19 (53%)
		C2H2 Zn finger	645..665	CDD:275368	8/19 (42%)
		C2H2 Zn finger	673..693	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860