DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and ZNF136

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_003428.1	Gene:	ZNF136 / 7695	HGNCID:	12920	Length:	540	Species:	Homo sapiens

Alignment Length:	455	Identity:	160/455 - (35%)
Similarity:	230/455 - (50%)	Gaps:	19/455 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 SQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHS----------TDKPFACTICQKTFA 315
            :|:|::  ||. |..:...||...|....:||.||:|.||          .:||.....|.|.|:
Human    89 NQNLSK--KIP-GVKLCESIVYGEVSMGQSSLNRHIKDHSGHEPKEYQEYGEKPDTRNQCWKPFS 150

  Fly   316 RKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHY 380
            .......|...||||..:.|:.|.|||...:.:..|:..|:|.||::|.:|.|:|.....:..|.
Human   151 SHHSFRTHEIIHTGEKLYDCKECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHE 215

  Fly   381 MWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPH 445
            ..|||:.|::|..|||.:|....:..||..||.:.|::|::|||.|.....|..|...||||.|.
Human   216 RSHTGEKPYECQECGKAFTCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQVHERIHTGEKPF 280

  Fly   446 RCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAF 510
            :|..|.|.|:....|..|.|.||||.|:.|..|.|.|:....|..|.|.||||.||.|..|.|||
Human   281 KCKQCGKAFSCSPTLRIHERTHTGEKPYECKQCGKAFSYLPSLRLHERIHTGEKPFVCKQCGKAF 345

  Fly   511 TRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNH 575
            ........|.|.||||.|::|..|.:.|:....:..|:.:|||:.|::|..|.|.|........|
Human   346 RSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEGPYKCKVCGKPFHSLSPFRIH 410

  Fly   576 VRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDR 640
            .|.|||:.|:.|::|.|.|.....:..|.|.|:.:.|:.|..|.|.|:.......| ...|||::
Human   411 ERTHTGEKPYVCKHCGKAFVSSTSIRIHERTHTGEKPYECKQCGKAFSYLNSFRTH-EMIHTGEK 474

  Fly   641 PFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGE-KPHAC 704
            ||.|:.|||:|....:...|:|:|| ||   :|:.|::|.|.:.|:.....||.:|:.: .|:.|
Human   475 PFECKRCGKAFRSSSSFRLHERTHT-GQ---KPYHCKECGKAYSCRASFQRHMLTHAEDGPPYKC 535

Fly 705 704
Human 536 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368	3/9 (33%)
		C2H2 Zn finger	279..299	CDD:275368	8/19 (42%)
		COG5048	300..723	CDD:227381	146/416 (35%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	4/19 (21%)
		C2H2 Zn finger	559..579	CDD:275368	6/19 (32%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	5/20 (25%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	1/1 (100%)
ZNF136	NP_003428.1	KRAB	3..44	CDD:307490
		C2H2 Zn finger	143..162	CDD:275368	4/18 (22%)
		COG5048	157..526	CDD:227381	137/373 (37%)
		C2H2 Zn finger	170..190	CDD:275368	6/19 (32%)
		C2H2 Zn finger	198..218	CDD:275368	5/19 (26%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..330	CDD:275368	7/19 (37%)
		C2H2 Zn finger	338..358	CDD:275368	7/19 (37%)
		C2H2 Zn finger	366..386	CDD:275368	4/19 (21%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		C2H2 Zn finger	450..470	CDD:275368	5/20 (25%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900