DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF132

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_003424.3	Gene:	ZNF132 / 7691	HGNCID:	12916	Length:	706	Species:	Homo sapiens

Alignment Length:	609	Identity:	205/609 - (33%)
Similarity:	292/609 - (47%)	Gaps:	81/609 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 GGIHGVDGSGNGGNGGGQNVAL------APDGTPIATGTHVCDICGKMFQFRYQLIVHRRYHSER 246
            |..|||:|.|....   |||::      .|:..|.....:.||:||...:....|..|:...||.
Human    78 GSWHGVEGEGAHPK---QNVSVEVLQVRIPNADPSTKKANSCDMCGPFLKDILHLAEHQGTQSEE 139

  Fly   247 KPFMCQVCGQGFTTSQDLTRHGKIHIGG------------------------------------- 274
            ||:.|..||:.|..:.:|.:|.|.|.||
Human   140 KPYTCGACGRDFWLNANLHQHQKEHSGGKPFRWYKDRDALMKSSKVHLSENPFTCREGGKVILGS 204

  Fly   275 -----------------------------PMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTIC 310
                                         .:|.|..|...|..:::|..|::.||.:.||.|...
Human   205 CDLLQLQAVDSGQKPYSNLGQLPEVCTTQKLFECSNCGKAFLKSSTLPNHLRTHSEEIPFTCPTG 269

  Fly   311 QKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEH 375
            ......|..|.|. :.||||.|..|:.|.|.|:....:..|.:.||....:.|..|.|:|..|..
Human   270 GNFLEEKSILGNK-KFHTGEIPHVCKECGKAFSHSSKLRKHQKFHTEVKYYECIACGKTFNHKLT 333

  Fly   376 YVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHT 440
            :|:|...|:|:.|::||.|||.::.:.||..|.:.||.|.||.|..||::||:..:|..|...||
Human   334 FVHHQRIHSGERPYECDECGKAFSNRSHLIRHEKVHTGERPFECLKCGRAFSQSSNFLRHQKVHT 398

  Fly   441 GETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTY 505
            ...|:.|..|.|:|:|...|:.|.|.||||.|:.||.|.:.|....:|..|.:.||||.||:|:.
Human   399 QVRPYECSQCGKSFSRSSALIQHWRVHTGERPYECSECGRAFNNNSNLAQHQKVHTGERPFECSE 463

  Fly   506 CTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKE 570
            |.:.|::..|::.|.:.||||.|.:|..|.|.|:....|..|.:.|||..|:.||.|:|:|:|..
Human   464 CGRDFSQSSHLLRHQKVHTGERPFECCDCGKAFSNSSTLIQHQKVHTGQRPYECSECRKSFSRSS 528

  Fly   571 HLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRC 635
            .|..|.|:|||:.|::|..|.|.|.....|..|.|.|:.:.|:.||.|.|.|::...||.| .:.
Human   529 SLIQHWRIHTGEKPYECSECGKAFAHSSTLIEHWRVHTKERPYECNECGKFFSQNSILIKH-QKV 592

  Fly   636 HTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEK 700
            |||::|:.|..|||.|..|.:|:.|.|.||.    |||:.|.:|.:.|....|||.|.|.|:.|:
Human   593 HTGEKPYKCSECGKFFSRKSSLICHWRVHTG----ERPYECSECGRAFSSNSHLVRHQRVHTQER 653

  Fly   701 PHACTLCSKAFVERGNLKRHMKMN 724
            |:.|..|.|||.||..|.||.|::
Human   654 PYECIQCGKAFSERSTLVRHQKVH 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	166/422 (39%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	10/17 (59%)
ZNF132	NP_003424.3	KRAB	37..78	CDD:307490	205/609 (34%)
		COG5048	105..528	CDD:227381	131/423 (31%)
		C2H2 Zn finger	116..136	CDD:275368	6/19 (32%)
		C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		C2H2 Zn finger	238..285	CDD:275368	13/47 (28%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		C2H2 Zn finger	321..341	CDD:275368	7/19 (37%)
		C2H2 Zn finger	349..369	CDD:275368	8/19 (42%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		COG5048	383..>706	CDD:227381	122/300 (41%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		C2H2 Zn finger	433..453	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		C2H2 Zn finger	489..509	CDD:275368	6/19 (32%)
		C2H2 Zn finger	517..537	CDD:275368	9/19 (47%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		C2H2 Zn finger	573..593	CDD:275368	8/20 (40%)
		C2H2 Zn finger	601..621	CDD:275368	9/19 (47%)
		C2H2 Zn finger	629..649	CDD:275368	8/19 (42%)
		C2H2 Zn finger	657..677	CDD:275368	11/19 (58%)
		C2H2 Zn finger	685..705	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.950