DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF222

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001123468.1	Gene:	ZNF222 / 7673	HGNCID:	13015	Length:	491	Species:	Homo sapiens

Alignment Length:	517	Identity:	155/517 - (29%)
Similarity:	214/517 - (41%)	Gaps:	117/517 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 FRYQLIV-HRRYHSERKPFMCQ----VCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTS 291
            ||..|.| |:.:|.:...|:.:    |.|   ||||   |.|  ::||.:            .|.
Human    50 FRNLLSVGHQPFHGDTFHFLREEKFWVMG---TTSQ---REG--NLGGKI------------QTE 94

  Fly   292 LERHMKRHSTDKPFAC-----------TICQKTFARKEHL----DNHFR-------SHTGETPFR 334
            :|. :....|.:.|:|           |..|.|......|    ||..:       .||.|.||:
Human    95 MET-VPEAGTHEEFSCKQIWEQIASDLTRSQDTTISNSQLFEQDDNPSQIKARLSTVHTREKPFQ 158

  Fly   335 CQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVN----HYMWHTGQTPHQCDVCG 395
            .:.|.:.|:.........:.::||..|.||.|.|||.    |::    |...|.|...::|||||
Human   159 GENCKQFFSDVSFFDLPQQLYSGEKSHTCDECGKSFC----YISALHIHQRVHMGVKCYKCDVCG 219

  Fly   396 KKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHL 460
            |::::...|..|.|.||.|.||:||.|||.|                   ||         :..|
Human   220 KEFSQSSRLQTHQRVHTGEKPFKCEQCGKGF-------------------RC---------RSAL 256

  Fly   461 LNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTG 525
            ..|.:.|..|.|:.|..|.|.|.....|..|.|.||||.||||..|.|:|..:..:..|...||.
Human   257 KVHCKLHMREKPYNCEKCGKAFMHNFQLQKHHRIHTGEKPFKCEICGKSFCLRSSLNRHCMVHTA 321

  Fly   526 ESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYC 590
            |..:|.....:.|..:..|..|...|.|..|:.|..|.|:|....:|..|.|:|||:.|:|||.|
Human   322 EKLYKSEKYGRGFIDRLDLHKHQMIHMGQKPYNCKECGKSFKWSSYLLVHQRVHTGEKPYKCEEC 386

  Fly   591 QKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKG 655
            .|.:..|..|:.|                             .|.|||:|.:.|:.|||||....
Human   387 GKGYISKSGLDFH-----------------------------HRTHTGERSYNCDNCGKSFRHAS 422

  Fly   656 NLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNL 717
            ::|.|::.|.:    .:|..||.|.|..:|:.:.....|.||||.|..|..|.|.:..|.||
Human   423 SILNHKKLHCQ----RKPLKCEDCGKRLVCRSYCKDQQRDHSGENPSKCEDCGKRYKRRLNL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/11 (45%)
		C2H2 Zn finger	251..271	CDD:275368	8/23 (35%)
		C2H2 Zn finger	279..299	CDD:275368	2/19 (11%)
		COG5048	300..723	CDD:227381	136/444 (31%)
		C2H2 Zn finger	307..327	CDD:275368	7/41 (17%)
		C2H2 Zn finger	335..355	CDD:275368	2/19 (11%)
		C2H2 Zn finger	363..383	CDD:275368	8/23 (35%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	3/19 (16%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	3/19 (16%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	1/20 (5%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	6/14 (43%)
ZNF222	NP_001123468.1	KRAB	17..76	CDD:214630	7/25 (28%)
		KRAB	17..56	CDD:279668	3/5 (60%)
		C2H2 Zn finger	160..179	CDD:275368	2/18 (11%)
		COG5048	<183..315	CDD:227381	56/163 (34%)
		C2H2 Zn finger	187..207	CDD:275368	8/23 (35%)
		C2H2 Zn finger	215..235	CDD:275368	9/19 (47%)
		zf-H2C2_2	228..252	CDD:290200	14/42 (33%)
		C2H2 Zn finger	243..263	CDD:275368	10/47 (21%)
		C2H2 Zn finger	271..291	CDD:275368	7/19 (37%)
		zf-H2C2_2	284..306	CDD:290200	13/21 (62%)
		C2H2 Zn finger	331..347	CDD:275368	3/15 (20%)
		C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		zf-H2C2_2	367..390	CDD:290200	12/22 (55%)
		C2H2 Zn finger	383..403	CDD:275368	8/48 (17%)
		C2H2 Zn finger	411..431	CDD:275368	8/19 (42%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900