DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF85

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_011526565.1	Gene:	ZNF85 / 7639	HGNCID:	13160	Length:	640	Species:	Homo sapiens

Alignment Length:	535	Identity:	193/535 - (36%)
Similarity:	265/535 - (49%)	Gaps:	51/535 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 YQLIVHRR--YHSERKPFMCQVCGQGFTTSQD---------LTRHG------------------- 268
            |.|::.|.  |.|.|  .||....|.....|:         |.|:|
Human   107 YILMLLRSVLYASVR--IMCSHFAQDLWPEQNIKDSFQKVTLKRYGKCRHENLPLRKGCESMDEC 169

  Fly   269 KIHIGG-------------PMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHL 320
            |:|.||             .:|.|.....|....::..||..||:..|||.||.|.|:|.....|
Human   170 KMHKGGCNGLNQCLTATQSKIFQCDKYVKVAHKFSNSNRHEIRHTKKKPFKCTKCGKSFGMISCL 234

  Fly   321 DNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTG 385
            ..|.|.||....::|:.|.|.|.....:..|.|.||||.|::|:.|.|:|.:..:.:.|...|||
Human   235 TEHSRIHTRVNFYKCEECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNQSSNLIKHKKIHTG 299

  Fly   386 QTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFC 450
            :.|::|:.|||.:.|...|..|...||.|.|::|:.|||:|:|....|.|...||||.|::|:.|
Human   300 EKPYKCEECGKTFNRFSTLTTHKIIHTGEKPYKCKECGKAFNRSSTLTTHRKIHTGEKPYKCEEC 364

  Fly   451 SKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDH 515
            .|.|.:..:|..|...||||.|::|..|.|.|.:..||..|...||||.|:||..|.|||....|
Human   365 GKAFKQSSNLTTHKIIHTGEKPYKCKKCGKAFNQSAHLTTHEVIHTGEKPYKCEKCGKAFNHFSH 429

  Fly   516 MVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHT 580
            :..|...||||.|:||..|.|.|.....||.|...|||:.|::|..|:|.|.:...||.|.::||
Human   430 LTTHKIIHTGEKPYKCKECGKAFKHSSTLTKHKIIHTGEKPYKCKECEKAFNQSSKLTEHKKIHT 494

  Fly   581 GDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCE 645
            |:.|::||.|.|.|.:..:|..|.:.|:.:.|:.|..|.|.|.....|..| ...|||::|:.||
Human   495 GEKPYECEKCGKAFNQSSNLTRHKKSHTEEKPYKCEECGKGFKWPSTLTIH-KIIHTGEKPYKCE 558

  Fly   646 TCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKA 710
            .|||:|.....|..|::.||.    |:|:.||:|.|.|....:|..|.|.|:||||:.|..|.||
Human   559 ECGKAFNQSSKLTKHKKIHTG----EKPYTCEECGKAFNQSSNLTKHKRIHTGEKPYKCEECDKA 619

  Fly   711 FVERGNLKRHMKMNH 725
            |.....|.:| |:.|
Human   620 FKWSSVLTKH-KIIH 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	3/10 (30%)
		C2H2 Zn finger	251..271	CDD:275368	7/47 (15%)
		C2H2 Zn finger	279..299	CDD:275368	4/19 (21%)
		COG5048	300..723	CDD:227381	167/422 (40%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF85	XP_011526565.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	189..603	CDD:227381	161/418 (39%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		zf-H2C2_2	262..286	CDD:290200	11/23 (48%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		zf-H2C2_2	289..314	CDD:290200	9/24 (38%)
		C2H2 Zn finger	305..325	CDD:275368	7/19 (37%)
		zf-H2C2_2	318..342	CDD:290200	11/23 (48%)
		C2H2 Zn finger	333..353	CDD:275368	8/19 (42%)
		zf-H2C2_2	346..370	CDD:290200	11/23 (48%)
		C2H2 Zn finger	361..381	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..398	CDD:290200	11/24 (46%)
		C2H2 Zn finger	389..409	CDD:275368	7/19 (37%)
		zf-H2C2_2	401..426	CDD:290200	14/24 (58%)
		C2H2 Zn finger	417..437	CDD:275368	7/19 (37%)
		zf-H2C2_2	429..454	CDD:290200	12/24 (50%)
		C2H2 Zn finger	445..465	CDD:275368	7/19 (37%)
		zf-H2C2_2	458..482	CDD:290200	11/23 (48%)
		C2H2 Zn finger	473..493	CDD:275368	7/19 (37%)
		zf-H2C2_2	486..510	CDD:290200	12/23 (52%)
		C2H2 Zn finger	501..521	CDD:275368	7/19 (37%)
		zf-H2C2_2	513..537	CDD:290200	7/23 (30%)
		C2H2 Zn finger	529..549	CDD:275368	6/20 (30%)
		zf-H2C2_2	542..566	CDD:290200	12/24 (50%)
		C2H2 Zn finger	557..577	CDD:275368	8/19 (42%)
		zf-H2C2_2	570..594	CDD:290200	11/27 (41%)
		C2H2 Zn finger	585..605	CDD:275368	8/19 (42%)
		zf-H2C2_2	597..621	CDD:290200	12/23 (52%)
		C2H2 Zn finger	613..633	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.950