DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF84

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001120844.1	Gene:	ZNF84 / 7637	HGNCID:	13159	Length:	738	Species:	Homo sapiens

Alignment Length:	507	Identity:	222/507 - (43%)
Similarity:	296/507 - (58%)	Gaps:	8/507 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 IATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCI 280
            ||.|   |..|||.|..:.|.|.|.|.|:..||:.|..||:.|:....||.|.:.|.|...:.|.
Human   233 IAFG---CGNCGKTFPQKSQFITHHRTHTGEKPYNCSQCGKAFSQKSQLTSHQRTHTGEKPYECG 294

  Fly   281 VCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRK 345
            .|...|:..:.|..|.:.|:.:||:.|..|.:.|:.|.:|.||.|.||||.||.|:.|.|.|:||
Human   295 ECGKAFSRKSHLISHWRTHTGEKPYGCNECGRAFSEKSNLINHQRIHTGEKPFECRECGKAFSRK 359

  Fly   346 EHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRS 410
            ..:|.|.|.|||..|..|..|:|:|..|...:.|...|||:.|::|..|.|.:..:..|.||.|:
Human   360 SQLVTHHRTHTGTKPFGCSDCRKAFFEKSELIRHQTIHTGEKPYECSECRKAFRERSSLINHQRT 424

  Fly   411 HTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRC 475
            ||.|.|..|..|||:||:|.|..:|.:.||||.|..|..|.|.|:||..|:.|.|.||||.|:.|
Human   425 HTGEKPHGCIQCGKAFSQKSHLISHQMTHTGEKPFICSKCGKAFSRKSQLVRHQRTHTGEKPYEC 489

  Fly   476 SYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTR 540
            |.|.|.|:.|..|.||.|.||||.|:.|:.|.|||.:|.|:::|.|.||||.|::|:.|.|.|..
Human   490 SECGKAFSEKLSLTNHQRIHTGEKPYVCSECGKAFCQKSHLISHQRTHTGEKPYECSECGKAFGE 554

  Fly   541 KEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMR 605
            |..|..|.|.|||:.|:.|..|:|.|::|..|..|.|:|||:.|::|..|:|.|..|..|..|:|
Human   555 KSSLATHQRTHTGEKPYECRDCEKAFSQKSQLNTHQRIHTGEKPYECSLCRKAFFEKSELIRHLR 619

  Fly   606 QHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEM 670
            .|:.:.|:.||.|.|.|..|..|||| .|.|||::||.|..|||:|..|.:|:.|||:||.
Human   620 THTGEKPYECNECRKAFREKSSLINH-QRIHTGEKPFECSECGKAFSRKSHLIPHQRTHTG---- 679

  Fly   671 ERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMK 722
            |:|:.|.:|.|.|..|..||:|.|.|:||||:.|..|.|||.::..|..|.:
Human   680 EKPYGCSECRKAFSQKSQLVNHQRIHTGEKPYRCIECGKAFSQKSQLINHQR 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	192/423 (45%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	11/20 (55%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	9/19 (47%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF84	NP_001120844.1	KRAB	9..68	CDD:214630
		C2H2 Zn finger	209..229	CDD:275368
		C2H2 Zn finger	237..257	CDD:275368	9/19 (47%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		zf-H2C2_2	278..302	CDD:316026	8/23 (35%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		COG5048	317..724	CDD:227381	190/411 (46%)
		C2H2 Zn finger	321..341	CDD:275368	8/19 (42%)
		C2H2 Zn finger	349..369	CDD:275368	9/19 (47%)
		C2H2 Zn finger	377..397	CDD:275368	6/19 (32%)
		C2H2 Zn finger	405..425	CDD:275368	7/19 (37%)
		C2H2 Zn finger	433..453	CDD:275368	9/19 (47%)
		C2H2 Zn finger	461..481	CDD:275368	9/19 (47%)
		C2H2 Zn finger	489..509	CDD:275368	10/19 (53%)
		C2H2 Zn finger	517..537	CDD:275368	9/19 (47%)
		C2H2 Zn finger	545..565	CDD:275368	8/19 (42%)
		C2H2 Zn finger	573..593	CDD:275368	8/19 (42%)
		C2H2 Zn finger	601..621	CDD:275368	8/19 (42%)
		C2H2 Zn finger	629..649	CDD:275368	11/20 (55%)
		C2H2 Zn finger	657..677	CDD:275368	10/19 (53%)
		C2H2 Zn finger	685..705	CDD:275368	9/19 (47%)
		C2H2 Zn finger	713..733	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860